Elastin content is high in the canine cruciate ligament and is associated with degeneration     

K.D. Smith  P.D. Clegg  J.F. Innes  E.J. Comerford 《Veterinary journal (London, England : 1997)》2014,199(1):169-174

Cruciate ligaments (CLs) are primary stabilisers of the knee joint and canine cranial cruciate ligament disease (CCLD) and rupture is a common injury. Elastin fibres, composed of an elastin core and fibrillin containing microfibrils, are traditionally considered minor components of the ligament extracellular matrix (ECM). However, their content and distribution in CLs is unknown. The purposes of this study were to determine the elastin content of canine CLs and to ascertain its relationship to other biochemical components and histological architecture.Macroscopically normal CLs were harvested from Greyhounds (n = 11), a breed with a low risk of CCLD. Elastin, collagen and sulfated glycosaminoglycan content were measured and histological scoring systems were developed to quantify ECM changes using a modified Vasseur score (mVS) and oxytalan fibre (bundles of microfibrils) staining. Elastin contents were 9.86 ± 3.97% dry weight in the cranial CL and 10.79 ± 4.37% in the caudal CL, respectively, and did not alter with advancing histological degeneration. All CLs demonstrated mild degenerative changes, with an average mVS score of 11.9 ± 3.3 (maximum 24). Increasing degeneration of the ligament ECM showed a positive correlation (r = 0.690, P < 0.001) with increased oxytalan fibre staining within the ECM.Elastin is an abundant protein in CLs forming a greater proportion of the ligament ECM than previously reported. The appearance of oxytalan fibres in degenerative CL ECM may reflect an adaptive or reparative response to normal or increased loads. This finding is important for future therapeutic or ligament replacement strategies associated with cranial CL injury.  相似文献   

Current evidence for non-pharmaceutical,non-surgical treatments of canine osteoarthritis     

C. Pye  N. Clark  N. Bruniges  M. Peffers  E. Comerford 《The Journal of small animal practice》2024,65(1):3-23

Osteoarthritis is a progressive degenerative disease process that affects a significant proportion of the canine population, impacting these animals' quality of life. Currently, there is no cure and treatment consists of managing the clinical signs of pain and reduced mobility. There are many treatments for canine osteoarthritis and in this review we discuss the evidence base behind non-pharmaceutical, non-surgical treatments of this disease. These treatments include weight management, nutraceuticals, acupuncture, physiotherapies such as therapeutic exercise, hydrotherapy as well as other therapeutic modalities including photobiomodulation therapy, electromagnetic field therapy and others.  相似文献   

GONG Observations of Solar Surface Flows     

DH Hathaway  PA Gilman  JW Harvey  F Hill  RF Howard  HP Jones  JC Kasher  JW Leibacher  JA Pintar  GW Simon 《Science (New York, N.Y.)》1996,272(5266):1306-1309

Doppler velocity observations obtained by the Global Oscillation Network Group (GONG) instruments directly measure the nearly steady flows in the solar photosphere. The sun's differential rotation is accurately determined from single observations. The rotation profile with respect to latitude agrees well with previous measures, but it also shows a slight north-south asymmetry. Rotation profiles averaged over 27-day rotations of the sun reveal the torsional oscillation signal-weak, jetlike features, with amplitudes of 5 meters per second, that are associated with the sunspot latitude activity belts. A meridional circulation with a poleward flow of about 20 meters per second is also evident. Several characteristics of the surface flows suggest the presence of large convection cells.  相似文献   

Late Pleistocene Desiccation of Lake Victoria and Rapid Evolution of Cichlid Fishes     

TC Johnson  CA Scholz  MR Talbot  K Kelts  RD Ricketts  G Ngobi  K Beuning  I Ssemmanda  JW McGill 《Science (New York, N.Y.)》1996,273(5278):1091-1093

Lake Victoria is the largest lake in Africa and harbors more than 300 endemic species of haplochromine cichlid fish. Seismic reflection profiles and piston cores show that the lake not only was at a low stand but dried up completely during the Late Pleistocene, before 12,400 carbon-14 years before the present. These results imply that the rate of speciation of cichlid fish in this tropical lake has been extremely rapid.  相似文献   

Primary,congenital neuroaxonal dystrophy with peripheral nerve demyelination in Merino–Border Leicester × Polled Dorset lambs          下载免费PDF全文

MC Hawes  JW Finnie  IV Jerrett  R Badman  M Scott 《Australian veterinary journal》2017,95(11):416-420

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Osteochondroma on the cranial aspect of the distal radial metaphysis causing tenosynovitis of the extensor carpi radialis tendon sheath in a horse          下载免费PDF全文

JW Russell  MS Hall  GM Kelly 《Australian veterinary journal》2017,95(1-2):46-48

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