Is the protected Atlantic cod (Gadus morhua) population in Gilbert Bay,Labrador, nearing a tipping point?     

Corey J. Morris  John M. Green 《水产资源保护:海洋与淡水生态系统》2021,31(10):2995-3002

1. The Gilbert Bay Marine Protected Area (MPA), Labrador, was created in 2005 to protect a resident, locally adapted population of Atlantic cod and its habitat. Twenty years of monitoring has shown a 90% decline in this bay-cod population since the creation of the MPA.
2. The decline of large commercial-sized cod in the bay was accompanied with increases in the abundance of other fish species, including rock cod (Gadus macrocephalus ogac), sculpin (Myoxocephlalus scorpius), and winter flounder (Pseudopleuronectes americanus), suggesting loss of strong top-down community control.
3. These changes suggest a positive feedback mechanism leading to a fish community tipping point, which could severely impact the recovery potential of the protected Atlantic cod population in the MPA.
4. We suggest that managers should be including this possibility in their management decisions for the Gilbert Bay MPA.

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In vitro efficacy of doxorubicin and etoposide against a feline injection site sarcoma cell line     

Joseph Hill  Jessica Lawrence  Corey Saba  Michelle Turek  Brittany Feldhaeusser  Sheryl Coutermarsh-Ott  Jamie Barber  Jo Smith  Robert Gogal Jr 《Research in veterinary science》2014

Feline injection site sarcoma (ISS) is a locally invasive tumor, in which surgical treatment is frequently combined with radiation or chemotherapy to improve tumor control. The focus of this study was to evaluate the cytotoxic effects of doxorubicin or etoposide on a feline injection site sarcoma cell line (JB) and to assess the impact of combining these drugs on cell death and cell cycle. Both single agent and combination drug administration increased cell death and significantly reduced the number of viable cells. Cells in G0/G1 were significantly reduced while the G2/M fraction was significantly increased following treatment. Collectively, combining doxorubicin and etoposide at the lower EC yielded comparable results to the EC50 of either drug alone in degree of cytotoxicity, level of apoptosis, and % of cells in G2/M. The results of this study indicate that doxorubicin and etoposide alone and in combination differentially alter ISS cell viability and cycle.  相似文献   

Detection of a Compact Radio Source near the Center of a Gravitational Lens: Quasar Image or Galactic Core?     

Gorenstein MV  Shapiro II  Cohen NL  Corey BE  Falco EE  Marcaide JM  Rogers AE  Whitney AR  Porcas RW  Preston RA  Rius A 《Science (New York, N.Y.)》1983,219(4580):54-56

By use of a new, very sensitive interferometric system, a faint, compact radio source has been detected near the center of the galaxy that acts as the main part of a gravitational lens. This lens forms two previously discovered images of the quasar Q09S7+561, which lies in the direction of the constellation Ursa Major. The newly detected source has a core smaller than 0.002 arc second in diameter with a flux density of 0.6 +/- 0.1 millijansky at the 13-centimeter wavelength of the radio observations. This source could be the predicted third image of the transparent gravitational lens, the central core of the galaxy, or some combination of the two. It is not yet possible to choose reliably between these alternatives.  相似文献   

Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level     

Moore CB  John M  James IR  Christiansen FT  Witt CS  Mallal SA 《Science (New York, N.Y.)》2002,296(5572):1439-1443

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Indirect computed tomography lymphangiography with aqueous contrast for evaluation of sentinel lymph nodes in dogs with tumors of the head          下载免费PDF全文

Janet A. Grimes  Scott A. Secrest  Nicole C. Northrup  Corey F. Saba  Chad W. Schmiedt 《Veterinary radiology & ultrasound》2017,58(5):559-564

Sentinel lymph node evaluation is widely used in human medicine to evaluate the first lymph node(s) to which a tumor drains. Sentinel lymph node biopsy allows avoidance of extensive lymphadenectomies in cases where the sentinel lymph node is negative for metastasis, thereby reducing patient morbidity. It has been shown that regional lymph nodes are not always the sentinel lymph node, thus identification and sampling of sentinel lymph nodes allows for more accurate staging, which is critical for treatment and prognostication in dogs with cancer. The objective of this prospective, pilot study was to determine if indirect computed tomography (CT) lymphangiography with aqueous contrast agent would successfully allow identification of sentinel lymph nodes in dogs with masses on the head. Eighteen dogs underwent CT lymphangiography. The sentinel lymph node was successfully identified within 3 min of contrast injection in 16 dogs (89%). Compression of lymphatic vessels from endotracheal tube ties and/or the patient's own body weight delayed or prevented identification of sentinel lymph nodes in two dogs (11%). Computed tomography lymphangiography with aqueous contrast can be used successfully to rapidly identify sentinel lymph nodes in dogs with masses on the head.  相似文献   

Protein mining the world's oceans: Australasia as an example of illegal expansion-and-displacement fishing   总被引：1，自引：0，他引：1  

Iain C. Field  Mark G. Meekan  Rik C. Buckworth  & Corey J. A. Bradshaw 《Fish and Fisheries》2009,10(3):323-328

Illegal, unreported and unregulated (IUU) fishing can lead to irreversible ecosystem changes; however, it is also one of the most difficult forms of fishing to manage and deter. In northern Australia over the past decade there has been a large increase in small-scale IUU fishing. We suggest that this small-scale fishing has arisen because of long-term fisheries over-exploitation in South East Asia. This IUU fishing forms part of the expansion-and-displacement cycle that can rapidly reduce biomass and alter the trophic structure of local ecosystems. With increasing human populations in the region, the pressure to fish illegally is likely to increase. Regional responses are required to deter and monitor the illegal over-exploitation of fisheries resources, which is critical to secure ecosystem stability as climate change and other destructive human activities threaten food security.  相似文献