ANTHROPOLOGY IN THE MEDICAL CURRICULUM     

Bean RB 《Science (New York, N.Y.)》1921,54(1399):371-373

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A METHOD OF HANDLING SMALL OBJECTS PREVIOUS TO SECTIONING     

Bean RJ 《Science (New York, N.Y.)》1927,65(1690):502-503

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Expression of biologically active recombinant porcine interleukin-12 from Escherichia coli     

Morris KR  Bruce MP  Janardhana V  Thomas JD  Bean AG  Strom DG 《Veterinary immunology and immunopathology》2008,126(3-4):373-376

The control of viral infections is of critical importance to livestock industries worldwide and is highlighted by costly infection outbreaks, such as that seen with foot and mouth disease virus. To ameliorate the impact of increasing problems with viral infections, new vaccine and anti-viral strategies are required and a greater understanding of the anti-viral response is essential. Furthermore, in pigs, evidence is still being gathered on the components of a defined anti-viral immune response. However, this has been greatly improved by the recent cloning and expression of critical cytokines involved in the anti-viral response. To assess the use of recombinant porcine interleukin-12 (rPoIL-12) as an immunotherapeutic and immunomodulator of swine, we have cloned and expressed rPoIL-12 as a single-chain fusion protein from Esherichia coli (E. coli). The fusion encodes the p40 and p35 subunits, linked by a glycine-serine linker and expressed as a C-terminal 6xHis tagged protein. rPoIL-12 stimulated the proliferation of human lymphoblasts and its activity on porcine cells was demonstrated by the ability of rPoIL-12 to increase the mRNA expression of porcine interleukin-18 receptor-alpha (poIL-18Ralpha) from porcine peripheral blood mononuclear cells (PoPMBCs). This data supports the inclusion of E. coli produced rPoIL-12 in immunomodulation strategies in the pig.  相似文献   

Predicting Wheat Quality Characteristics and Functionality Using Near‐Infrared Spectroscopy     

F. E. Dowell  E. B. Maghirang  F. Xie  G. L. Lookhart  R. O. Pierce  B. W. Seabourn  S. R. Bean  J. D. Wilson  O. K. Chung 《Cereal Chemistry》2006,83(5):529-536

The accuracy of using near‐infrared spectroscopy (NIRS) for predicting 186 grain, milling, flour, dough, and breadmaking quality parameters of 100 hard red winter (HRW) and 98 hard red spring (HRS) wheat and flour samples was evaluated. NIRS shows the potential for predicting protein content, moisture content, and flour color b* values with accuracies suitable for process control (R² > 0.97). Many other parameters were predicted with accuracies suitable for rough screening including test weight, average single kernel diameter and moisture content, SDS sedimentation volume, color a* values, total gluten content, mixograph, farinograph, and alveograph parameters, loaf volume, specific loaf volume, baking water absorption and mix time, gliadin and glutenin content, flour particle size, and the percentage of dark hard and vitreous kernels. Similar results were seen when analyzing data from either HRW or HRS wheat, and when predicting quality using spectra from either grain or flour. However, many attributes were correlated to protein content and this relationship influenced classification accuracies. When the influence of protein content was removed from the analyses, the only factors that could be predicted by NIRS with R² > 0.70 were moisture content, test weight, flour color, free lipids, flour particle size, and the percentage of dark hard and vitreous kernels. Thus, NIRS can be used to predict many grain quality and functionality traits, but mainly because of the high correlations of these traits to protein content.  相似文献   

Evaluation of the Single Kernel Characterization System (SKCS) for Measurement of Sorghum Grain Attributes     

S. R. Bean  O. K. Chung  M. R. Tuinstra  J. F. Pedersen  J. Erpelding 《Cereal Chemistry》2006,83(1):108-113

The single kernel characterization system (SKCS) has been widely used in the wheat industry, and SKCS parameters have been linked to end‐use quality in wheat. The SKCS has promise as a tool for evaluating sorghum grain quality. However, the SKCS was designed to analyze wheat, which has a different kernel structure from sorghum. To gain a better understanding of the meaning of SKCS predictions for grain sorghum, individual sorghum grains were measured for length, width, thickness (diameter), and weight by laboratory methods and by the SKCS. SKCS predictions for kernel weight and thickness were highly correlated to laboratory measurements. However, SKCS predictions for kernel thickness were underestimated by ≈20%. The SKCS moisture prediction for sorghum was evaluated by tempering seven samples with varying hardness values to four moisture levels. The moisture contents predicted by SKCS were compared with a standard oven method and, while correlated, SKCS moisture predictions were less than moisture measured by air oven, especially at low moisture content. Finally, SKCS hardness values were compared with hardness measured by abrasive decortication. A moderate (r = 0.67, P < 0.001) correlation was observed between the hardness measurements. The SKCS predictions of kernel weight and diameter were highly correlated with laboratory measurement. Moisture prediction, however, was substantially lower by the SKCS than as measured by an air oven method. The SKCS should be suitable for measuring sorghum grain attributes. Further research is needed to determine how SKCS hardness predictions are correlated to milling properties of sorghum grain.  相似文献   

FISHES OF THE SOUTH SHORE OF LONG ISLAND     

Bean TH 《Science (New York, N.Y.)》1899,9(211):52-55

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A RARE 'WHALE SHARK.'     

Bean BA 《Science (New York, N.Y.)》1902,15(374):353-355

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A SCHEME TO REPRESENT TYPE HEREDITY IN MAN     

Bean RB 《Science (New York, N.Y.)》1909,29(754):942-944

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Accelerated human population growth at protected area edges   总被引：1，自引：0，他引：1  

Wittemyer G  Elsen P  Bean WT  Burton AC  Brashares JS 《Science (New York, N.Y.)》2008,321(5885):123-126

Protected areas (PAs) have long been criticized as creations of and for an elite few, where associated costs, but few benefits, are borne by marginalized rural communities. Contrary to predictions of this argument, we found that average human population growth rates on the borders of 306 PAs in 45 countries in Africa and Latin America were nearly double average rural growth, suggesting that PAs attract, rather than repel, human settlement. Higher population growth on PA edges is evident across ecoregions, countries, and continents and is correlated positively with international donor investment in national conservation programs and an index of park-related funding. These findings provide insight on the value of PAs for local people, but also highlight a looming threat to PA effectiveness and biodiversity conservation.  相似文献   

Reconstruction of Current Flow and Imaging of Current-Limiting Defects in Polycrystalline Superconducting Films     

AE Pashitski  A Gurevich  AA Polyanskii  DC Larbalestier  A Goyal  ED Specht  DM Kroeger  JA DeLuca  JE Tkaczyk 《Science (New York, N.Y.)》1997,275(5298):367-369

Magneto-optical imaging was used to visualize the inhomogeneous penetration of magnetic flux into polycrystalline TlBa2Ca2Cu3Ox films with high critical current densities, to reconstruct the local two-dimensional supercurrent flow patterns and to correlate inhomogeneities in this flow with the local crystallographic misorientation. The films have almost perfect c-axis alignment and considerable local a- and b-axis texture because the grains tend to form colonies with only slightly misaligned a and b axes. Current flows freely over these low-angle grain boundaries but is strongly reduced at intermittent colony boundaries of high misorientation. The local (<10-micrometer scale) critical current density Jc varies widely, being up to 10 times as great as the transport Jc (scale of approximately 1 millimeter), which itself varies by a factor of about 5 in different sections of the film. The combined experiments show that the magnitude of the transport Jc is largely determined by a few high-angle boundaries.  相似文献