Equine herpesvirus 1 HVS25A isolated from an aborted foetus produces disease in Balb/C mice     

H. CSELLNER  JM WHALLEY  DN LOVE 《Australian veterinary journal》1995,72(2):68-69

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The pharmacokinetics of some aminoglycoside antibiotics in the horse     

J. D. BAGGOT  DARIA N. LOVE  R. J. ROSE†  J. RAUS 《Journal of veterinary pharmacology and therapeutics》1981,4(4):277-284

The disposition kinetics and bioavailability of streptomycin, kanamycin and neomycin were determined following their administration as parenteral preparations to horses. Single doses (10 mg/kg) of each aminoglycoside were given by the intravenous (i.v.) and intramuscular (i.m.) routes and, at a later time, seven intramuscular doses were injected at 12-h intervals. The pharmacokinetic behaviour of the three aminoglycosides was similar, in that a rapid distribution phase was followed by a relatively short half-life. The half-life (mean ± SD, n= 6) of kanamycin (1.80 ± 0.17 h) was significantly (P<0.01; t test, 10 d.f.) shorter than that of streptomycin (3.40 ± 0.42 h), while neomycin half-life (2.10 ± 0.97 h) was of an intermediate length. The apparent volume of distribution of neither kanamycin nor neomycin varied significantly (P > 0.05) from that of streptomycin and numerically (V¹ d = 230 ml/kg) was the same as the extracellular fluid volume. The body clearance of kanamycin (88.5 ± 11.3 ml/kg.h) was significantly (P < 0.01) larger than that of streptomycin (47.5 ± 7.9 ml/kg.h), while a significant difference in this parameter did not exist (P > 0.05) between neomycin and streptomycin. Following intramuscular injection, each aminoglycoside was rapidly and completely absorbed from the injection site, although neomycin showed wide individual variation in the fraction absorbed. The administration of multiple doses did not change either the bioavailability or the apparent half-life from the values obtained after a single dose. The only pharmacokinetic difference between these aminoglycosides that is of clinical importance lies in the rate of their elimination. A dosage interval of 8 h would be appropriate for kanamycin compared with a 12-h interval for streptomycin. The dosage interval for neomycin based on half-life should be 8 h but, due to the relatively greater toxicity of this aminoglycoside, an interval of 12 h might be recommended. The height of the peak serum concentration is determined by the size of the dose.  相似文献   

Effects of posture and accumulated airway secretions on tracheal mucociliary transport in the horse     

SHARANNE L RAIDAL  DARIA N LOVE  GD BAILEY 《Australian veterinary journal》1996,73(2):45-49

Tracheal mucociliary clearance was determined in horses by measuring the rostrad transport of the radiopharmaceutical ^99mtechnetium-sulphur colloid following deposition on the tracheal epithelium by intratracheal injection. The effects of head position (head elevated to normal standing position vs head lowered) and of accumulated purulent secretions on tracheal mucociliary clearance were evaluated for the first time in the horse. In normal horses tracheal mucociliary clearance was greatly accelerated by lowering the head so that the cranial trachea was lower than the caudal trachea. Horses confined with their heads elevated for 24 hours developed an accumulation of purulent airway secretions (and associated increased numbers of bacteria) in the lower respiratory tract and showed a decrease in tracheal mucociliary clearance when compared with their previously measured rate when the lower airway contained only normal secretions. These findings have implications for management practices where horses are prevented from lowering their heads, such as transportation and cross-tying, which may therefore contribute to lower respiratory tract disease in horses.  相似文献   

Zinc -65 in reactor workers     

COHN SH  LOVE RA  GUSMANO EA 《Science (New York, N.Y.)》1961,133(3461):1362-1363

Zinc-65, hitherto found in cyclotron workers and in other specialized populations, has now been detected in a group of reactor workers. While the highest levels detected are less than 0.2 percent of the maximum permissible concentration, the movement of this neutron-induced radionuclide is of interest, and the baseline information is important for future studies.  相似文献   

Biofilm formation by virulent and non-virulent strains of Haemophilus parasuis     

Bernardo Bello-Ortí  Vincent Deslandes  Yannick DN Tremblay  Josée Labrie  Kate J Howell  Alexander W Tucker  Duncan J Maskell  Virginia Aragon  Mario Jacques 《Veterinary research》2014,45(1)

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Feeding grain contaminated with Fusarium gramineamm and Fusarium moniliforme to pigs and chickens     

W L BRYDEN  R J LOVE †  L W BURGESS ‡ 《Australian veterinary journal》1987,64(7):225-226

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Pyometra and pyovagina in koalas     

P. J. CANFIELD  C. J. OXENFORD  D. N. LOVE  R. K. DICKENS 《Australian veterinary journal》1983,60(11):337-338

SUMMARY Four female koalas were found to have pyometra and pyovagina at autopsy. All had soiling of fur around the cloaca and were in poor condition. One koala had cystic ovaries in addition to the pyometra while another had extensive peritonitis due to rupture of one of the uterine horns. Chronic cystitis was present in all koalas while one also had pyelonephritis. Microbiological examination revealed a mixed flora of both aerobes and anaerobes.  相似文献   

Characterization of strains of Staphylococci from infections in dogs and cats   总被引：2，自引：0，他引：2  

DARIA N. LOVE  G. LOMAS  MARILYN BAILEY  R. F. JONES  I. WESTON 《The Journal of small animal practice》1981,22(4):195-199

Forty strains of Staphylococci from infections of dogs and cats were characterized with respect to their coagulase and thermonuclease activities, and 19 strains for their fermentation of mannitol anaerobically. Thermonuclease correlated well with tube coagulase activity but there was a poor correlation between these two characters, the ability to ferment mannitol anaerobically, and the presence of bound coagulase. Fifty percent of the organisms were resistant to penicillin due to the presence of β-lactamase (penicillinase). There was a strict correlation between detection of β-lactamase by the disc diffusion and the slide penicillinase tests. Antibiotics to which organisms were resistant also were bacitracin (52·5%), lincomycin (20%), streptomycin (17·5%), tetracyclines (12·5%) and chloramphenicol (7·5%).  相似文献   

Bacteriology of the horizontal ear canal of dogs     

D. B. DICKSON  DARIA N. LOVE 《The Journal of small animal practice》1983,24(7):413-421

Of 57 dogs included in a survey of the bacteriology of the horizontal ear canal, 31 showed clinical signs consistent with ear irritation. Twenty-six dogs were presented for other reasons and were asymptomatic for ear irritation. All dogs sampled were anaesthetized and sterile moistened swabs used to sample the horizontal ear canal. Swabs were introduced through a sterilized (121°C for 15 min) polypropylene otoscope cone and care was taken to prevent contamination of the cone with material from elsewhere in the ear canal. Swabs were processed within 20 min of sampling and cultures were incubated aerobically and anaerobically. Swabs from the ears of asymptomatic dogs were mixed in broth prior to plating to ensure optimal elution of small numbers of organisms from the swabs. Very small numbers of bacteria and yeasts were isolated from asymptomatic dogs while Pseudomonas spp. and Proteus spp. were frequent isolates from symptomatic dogs with chronic irritation. The significance of these findings is discussed in relation to the sampling and culturing techniques used in this and other surveys.  相似文献   

Noradrenergic Control of GnRH Release from the Ewe Hypothalamus In Vitro: Sensitivity to Oestradiol     

SPS Ghuman  DN Jones  S Prabhakar  RF Smith  H Dobson 《Reproduction in domestic animals》2008,43(6):753-759

The present study investigates the influence of α₁‐adrenoreceptors in GnRH release in vitro and determines whether oestradiol modulates α₁‐adrenoreceptor‐GnRH interaction. Within 10 min after ewe sacrifice, saggital midline hypothalamic slices were dissected, placed in oxygenated Minimum Essential Media‐α (MEM‐α) at 4°C and within 2 h were singly perifused at 37°C with oxygenated MEM‐α (pH 7.4; flow rate 0.15 ml/min), either with or without oestradiol (24 pg/ml). After 4‐h equilibration, 10‐min fractions were collected for 4 h interposed with a 10‐min exposure at 60 min to specific α₁‐adrenoreceptor agonist (methoxamine) or antagonist (thymoxamine) at various doses (0.1–10 mm ). The α₁‐adrenoreceptor agonist (10 mm ) increased (p < 0.05) GnRH release at 90 min both in presence and absence of oestradiol. However, in presence of oestradiol, α₁‐adrenoreceptor agonist (10 mm )‐induced GnRH release remained elevated (p < 0.05) for at least 60 min. The bioactivity of the released GnRH was studied using a hypothalamus–pituitary sequential double‐chamber perifusion. Only after exposure of hypothalamic slices to α₁‐adrenoreceptor agonist (10 mm ), did the hypothalamic eluate stimulate LH release from pituitary fragments (n = 9, 7.8 ± 12.3–36.2 ± 21.6 ng/ml) confirming that the α₁‐adrenoreceptor agonist stimulated release of biologically active GnRH. In summary, GnRH release from the hypothalamus is under stimulatory noradrenergic control and this is potentiated in the presence of oestradiol.  相似文献