Phase II Clinical Trial of Carboplatin in Canine Transitional Cell Carcinoma of the Urinary Bladder   总被引：4，自引：3，他引：1  

Ruthanne Chun  Deborah W. Knapp  William R. Widmer  Dennis B. DelNicola  Nita W. Glickman  Thomas Kuczek  Amalia Degortari  Connie M. Han 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1997,11(5):279-283

Fourteen dogs with histologically-confirmed transitional cell carcinoma (TCC) of the urinary bladder were treated with 300 mg/m² carboplatin every 3 weeks. Response to therapy was assessed with abdominal radiography, double contrast cystography, urinary bladder ultrasonography and thoracic radiography before therapy and at 6–week intervals during therapy. Dogs were monitored for hematologic toxicity with a CBC and platelet count performed immediately before and 10 to 14 days after carboplatin treatment. Tumor responses included progressive disease in 11 dogs and stable disease in 1 dog. Two dogs were euthanized due to carboplatin toxicity before assessment of tumor response. Toxicity included thrombocytopenia with or without neutropenia in 7 dogs and gastrointestinal toxicity in 6 dogs. Carboplatin therapy was not beneficial in the treatment of TCC in the 14 dogs in this study.  相似文献   

The North American long-term soil productivity experiment: Findings from the first decade of research   总被引：1，自引：0，他引：1  

Robert F. Powers  D. Andrew Scott  Felipe G. Sanchez  Richard A. Voldseth  Deborah Page-Dumroese  John D. Elioff  Douglas M. Stone 《Forest Ecology and Management》2005,220(1-3):31-50

First decade findings on the impacts of organic matter removal and soil compaction are reported for the 26 oldest installations in the nation-wide network of long-term soil productivity sites. Complete removal of surface organic matter led to declines in soil C concentration to 20 cm depth and to reduced nutrient availability. The effect is attributed mainly to the loss of the forest floor. Soil C storage seemed undiminished, but could be explained by bulk density changes following disturbance and to decomposition inputs of organic C from roots remaining from the harvested forest. Biomass removal during harvesting had no influence on forest growth through 10 years. Soil compaction effects depended upon initial bulk density. Soils with densities greater than 1.4 Mg m⁻³ resisted compaction. Density recovery was slow, particularly on soils with frigid temperature regimes. Forest productivity response to soil compaction depended both on soil texture and the degree of understory competition. Production declined on compacted clay soils, increased on sands, and generally was unaffected if an understory was absent.  相似文献   

Differential responses of Bolivian timber species to prescribed fire and other gap treatments     

Deborah K.?KennardEmail author  Francis E.?Putz 《New Forests》2005,30(1):1-20

We followed the establishment and growth response of 13 commercial tree species to canopy opening, above-ground biomass removal, and experimental burns of low and high intensities in a lowland dry forest in Bolivia. Three patterns of response to treatments were observed among the most abundant commercial tree species. (1) Shade-intolerant species regenerated mostly from seed and had the highest survival and growth rates following high-intensity burns. (2) Shade-tolerant species were abundant in gap control and plant removal treatments. Treatments had little effect on the height growth of these species. (3) Individuals of root sprouting species were most abundant following plant removal and low-intensity burn treatments. Treatments had little effect on the height growth of these species. The wide variation in species responses to gap treatments found in this study not only reinforces the concept that species are distributed along a continuum of shade-tolerance levels, but that other aspects of species biology, such as seed dispersal type or sprouting behavior, further differentiate regeneration strategies. The variety of regeneration strategies found among the species at this forest site will require a flexible management scheme that mixes more intensive silvicultural treatments such as prescribed burning with less intensive treatments.  相似文献   

Comparison of levels and duration of detection of antibodies to bovine viral diarrhea virus 1, bovine viral diarrhea virus 2, bovine respiratory syncytial virus,bovine herpesvirus 1, and bovine parainfluenza virus 3 in calves fed maternal colostrum or a colostrum-replacement product     

Manuel F. Chamorro  Paul H. Walz  Deborah M. Haines  Thomas Passler  Thomas Earleywine  Roberto A. Palomares  Kay P. Riddell  Patricia Galik  Yijing Zhang  M. Daniel Givens 《Canadian journal of veterinary research》2014,78(2):81-88

Colostrum-replacement products are an alternative to provide passive immunity to neonatal calves; however, their ability to provide adequate levels of antibodies recognizing respiratory viruses has not been described. The objective of this study was to compare the serum levels of IgG at 2 d of age and the duration of detection of antibodies to bovine viral diarrhea virus 1 (BVDV-1), bovine viral diarrhea virus 2 (BVDV-2), bovine respiratory syncytial virus (BRSV), bovine herpesvirus 1 (BHV-1), and bovine parainfluenza virus 3 (BPIV-3) in calves fed maternal colostrum (MC) or a colostrum replacement (CR) at birth. Forty newborn male Holstein calves were assigned to the CR or the MC group. Group CR (n = 20) received 2 packets of colostrum replacement (100 g of IgG per 470-g packet), while group MC (n = 20) received 3.8 L of maternal colostrum. Blood samples for detection of IgG and virus antibodies were collected from each calf at birth, at 2 and 7 d, and monthly until the calves became seronegative. Calves in the MC group had greater IgG concentrations at 2 d of age. The apparent efficiency of absorption of IgG was greater in the MC group than in the CR group, although the difference was not significant. Calves in the CR group had greater concentrations of BVDV neutralizing antibodies during the first 4 mo of life. The levels of antibodies to BRSV, BHV-1, and BPIV-3 were similar in the 2 groups. The mean time to seronegativity was similar for each virus in the 2 groups; however, greater variation was observed in the antibody levels and in the duration of detection of immunity in the MC group than in the CR group. Thus, the CR product provided calves with more uniform levels and duration of antibodies to common bovine respiratory viruses.  相似文献   

Investigation of the Role of Androstenedione-19-oic Acid in the Presence of 19-Norandrostenedione in Intact Male Horse Plasma Using Liquid Chromatography–Tandem Mass Spectrometry     

Youwen You  Cornelius E. Uboh  Lawrence R. Soma  Fuyu Guan  Daniel Taylor  Xiaoqing Li  Ying Liu  Deborah Tsang 《Journal of Equine Veterinary Science》2014

A liquid chromatography–tandem mass spectrometry method was developed to confirm the presence of androstenedione-19-oic acid in intact male equine plasma and to show the source of 19-norandrostenedione in equine plasma. Androstenedione-19-oic acid was recovered from acidified plasma by liquid–liquid extraction using methyl tert-butyl ether and separated on an Ace 5 C₈ column. A triple quadrupole mass spectrometer was used to detect the analytes in negative electrospray ionization mode. Limits of detection, quantification, and confirmation of the method were 0.1, 0.5, and 1.0 ng/mL, respectively. The linear dynamic range of quantification was 0.5–50 ng/mL. The presence of androstenedione-19-oic acid was confirmed in all plasma samples obtained from intact male horses but not those from gelded and female horses; the average concentration was 3.1 ± 1.6 ng/mL, suggesting androstenedione-19-oic acid is an endogenous compound only in intact male horse plasma samples. The conversion of androstenedione-19-oic acid to 19-norandrostenedione in equine plasma was demonstrated by spiking androstenedione-19-oic acid into blank plasma and monitoring the generation of 19-norandrostenedione and its increase in concentration during storage. Results indicated that androstenedione-19-oic acid was readily converted into 19-norandrostenedione; the higher the storage temperature, the faster the conversion. The conversion was not affected by the types of plasma samples collected from gelded and female horses or by anticoagulants used in blood collection to harvest plasma. Compared with other matrices such as water, methanol, and phosphate-buffered saline, the conversion of androstenedione-19-oic to 19-norandrostenedione in equine plasma was faster, suggesting that there is an unknown factor(s) in equine plasma that enhances the conversion.  相似文献   

The relative influence of catchment and site variables on fish and macroinvertebrate richness in cerrado biome streams     

Diego R. Macedo  Robert M. Hughes  Raphael Ligeiro  Wander R. Ferreira  Miriam A. Castro  Nara T. Junqueira  Deborah R. Oliveira  Kele R. Firmiano  Philip R. Kaufmann  Paulo S. Pompeu  Marcos Callisto 《Landscape Ecology》2014,29(6):1001-1016

Landscape and site-scale data analyses aid the interpretation of biological data and thereby help us develop more cost-effective natural resource management strategies. Our study focused on environmental influences on stream assemblages and we evaluated how three classes of environmental variables (geophysical landscape, land use and cover, and site habitat), influence fish and macroinvertebrate assemblage richness in the Brazilian Cerrado biome. We analyzed our data through use of multiple linear regression (MLR) models using the three classes of predictor variables alone and in combination. The four MLR models explained dissimilar amounts of benthic macroinvertebrate taxa richness (geophysical landscape R ² ≈ 35 %, land use and cover R ² ≈ 28 %, site habitat R ² ≈ 36 %, and combined R ² ≈ 51 %). For fish assemblages, geophysical landscape, land use and cover, site habitat, and combined models explained R ² ≈ 28 %, R ² ≈ 10 %, R ² ≈ 31 %, and R ² ≈ 47 % of the variability in fish species richness, respectively. We conclude that (1) environmental variables differed in the degree to which they explain assemblage richness, (2) the amounts of variance in assemblage richness explained by geophysical landscape and site habitat were similar, (3) the variables explained more variability in macroinvertebrate taxa richness than in fish species richness, and (4) all three classes of environmental variables studied were useful for explaining assemblage richness in Cerrado headwater streams. These results help us to understand the drivers of assemblage patterns at regional scales in tropical areas.  相似文献   

Presumptive cocaine toxicosis in 19 dogs: 2004–2012     

Emily K. Thomas BA  VetMB  MRCVS  Kenneth J. Drobatz DVM  MSCE  DACVIM  DACVECC  Deborah C. Mandell VMD  DACVECC 《Journal of Veterinary Emergency and Critical Care》2014,24(2):201-207

  相似文献   

Mosaic stunting in bareroot Pinus banksiana seedlings is unrelated to colonization by mycorrhizal fungi     

Lynette R. Potvin  Martin F. Jurgensen  R. Kasten Dumroese  Dana L. Richter  Deborah S. Page-Dumroese 《New Forests》2014,45(6):893-903

Mosaic stunting, the occurrence of random patches of chlorotic seedlings with reduced shoot and diameter growth amidst more robust cohorts within bareroot nurseries, is classically associated with poor colonization by mycorrhizal fungi. We examined possible relationships among soil fertility, mycorrhizas, and random patches of mosaic stunting in bareroot Pinus banksiana Lamb. and suggest this paradigm is not universal. Stunted seedlings were distributed among healthy seedlings, occupied field space for 2–3 years, and used nursery resources (i.e. irrigation, fertilization); consequently high rates of culling at harvest resulted in an economic stress for the nursery. Thus, an understanding of the cause(s) of stunting was necessary. Stunted 1 + 0 seedlings had significantly lower levels of nitrogen, phosphorus, potassium, and zinc than their healthy cohorts, despite similar soil nutrient levels. The numbers of mycorrhizal root tips on stunted and healthy seedlings were similar, and the taxa of mycorrhizal fungi, determined by isolations and DNA sequencing, were not consistently associated with stunted or healthy seedlings. We conclude that differences in Pinus banksiana mycorrhizas are not responsible for mosaic stunting, but may be caused by localized low soil N availability due to uneven distribution of added organic matter amendments.  相似文献   

A world view     

Deborah Storie 《Australian veterinary journal》2000,78(3):205-206

  相似文献   

The effects of delays between restraint and sampling on some blood parameters in sheep     

Fenwick  D. C.  Blackshaw  Judith K.  Green  Deborah J. 《Veterinary research communications》1986,10(1):309-315

Twenty three non pregnant, non lactating aged Merino and Border Leicester ewes were subject to four jugular venipunctures one hour apart (times 0, 1, 2 and 3). Four different delay intervals of 12.5, 64.0, 128.0 and 252.9 seconds between catching and sampling (delays 1, 2, 3 and 4) were used on each sheep in a random manner. Estimates were made of packed cell volumes (PCVs), plasma and erythrocyte sodium and potassium concentrations. The mean PCV at time 0 of 35.4 per cent was significantly higher than the levels of 33.1, 31.8 and 32.2 per cent at times 1, 2 and 3 respectively. There was no significant difference between the means at times 1, 2 and 3. The mean plasma potassium concentrations at time 0 of 4.37 mmol/l was significantly higher than the levels of 4.16 and 4.14 mmol/l at times 1 and 3 respectively. Delays had no significant effects on the means of any of the parameters studied. The findings strongly suggest that sheep become excited by initial handling but not by subsequent venipunctures and that a delay between catching and sampling of between 12.5 and 252.9 second has no effect on the blood constituents studied.  相似文献