Parenteral Anticholinergics in Dogs With Normal and Elevated Intraocular Pressure   总被引：1，自引：0，他引：1  

KAREN J. FRISCHMEYER dvm    PAUL E. MILLER dvm  diplomate acvo    YVONNE BELLAY dvm  MS    STEPHANIE L. SMEDES DVM  Diplomate ACVO  DAVID B. BRUNSON dvm  MS  Diplomate ACVA 《Veterinary surgery : VS》1993,22(3):230-234

Dogs given parenteral anticholinergic drugs have been thought to be at risk for development or exacerbation of elevated intraocular pressure (IOP). In a randomized, blinded, placebo-controlled study, we evaluated the effect of intramuscular glycopyrrolate (0.01 mg/kg) on pupil diameter and IOP in unanesthetized normal dogs. Treatment with glycopyrrolate did not change pupil diameter or IOP from baseline, nor were there differences between glycopyrrolate and saline-treated (control) dogs. In addition, the authors retrospectively reviewed the medical records of 2,828 dogs undergoing general anesthesia between April 1987 and September 1990 to determine if there was an association between parenteral anticholinergic medication and postanesthetic elevation in IOP. The authors also determined the frequency of bradycardia requiring anticholinergic therapy during anesthesia in dogs with glaucoma. Of the 2,828 cases reviewed, the records of 46 dogs coded for glaucoma were examined in detail. The 46 dogs underwent 62 episodes of anesthesia, with 23 episodes including exposure to an anticholinergic drug. An increase in IOP from preanesthetic to postanesthetic measurement occurred in three dogs. One of these dogs received anticholinergic medication for bradycardia during anesthesia. The postanesthetic elevation in IOP in this dog was probably not drug related. Preanesthetic anticholinergic administration did not affect the incidence of anticholinergic administration for bradycardia during the anesthetic episode. Anticholinergic therapy during anesthesia was more frequent when the preanesthetic medication included an opiate drug. These studies do not indicate an association between parenteral anticholinergic administration and elevations in IOP.  相似文献   

USE OF ULTRASOUND-GUIDED FINE-NEEDLE ASPIRATION BIOPSY AND AUTOMATED CORE BIOPSY FOR THE DIAGNOSIS OF GASTROINTESTINAL DISEASES IN SMALL ANIMALS     

Mitchell A.  Crystal  DVM  Dominique G.  Penninck  DVM  Michael E.  Matz  DVM  Susan H.  Pearson  BA  Greg O.  Freden  DVM  Richard M.  Jakowski  DVM 《Veterinary radiology & ultrasound》1993,34(6):438-444

The purpose of this study was to evaluate the usefulness of ultrasound-guided fine-needle aspiration biopsy and core biopsy in the diagnosis of infiltrative gastrointestinal diseases. Six dogs and seven cats with clinical signs of gastrointestinal disease underwent ultrasonography and intestinal lesions were identified. One or more ultrasound-guided fine-needle aspiration biopsy and/or core biopsy procedures were performed in each patient. Each patient also underwent one of the following additional procedures for comparison of results: 1) surgery (n=4), 2) endoscopy (n=2), 3) post mortem exam (n=3), and, 4) for lymphoma diagnosed with ultrasound-guided procedures, response to chemotherapy (n=4). Correct diagnoses were obtained in nine of the 13 patients, incorrect diagnoses in two of the 13 patients, and inconclusive diagnoses in two of the thirteen patients. Of the 16 total ultrasound-guided procedures performed, ten were confirmed as correct, three as incorrect, and three were non-diagnostic. Intestinal lesions with bowel wall thickness greater than 2.0 cm had a higher percentage of correct diagnoses than lesions of lesser wall thickness. Gastric lesions had a higher percentage of correct diagnoses than small and large intestinal lesions. Malignant lesions had a higher percentage of correct diagnoses than benign lesions. There were no complications. Ultrasound-guided gastrointestinal fine-needle aspiration biopsy and core biopsy appears to be a safe, accurate, and rapid procedure for use in the diagnosis of infiltrative gastrointestinal disease.  相似文献   

The effects of a compressible plastic shoe - The Seattle shoe®- on the kinematics of the strides of galloping thoroughbred horses     

Patrick D. Wilson MS  DVM  Marc H. Ratzlaff DVM  PhD  Barrie D. Grant DVM  MS  Martha L. Hyde PhD  Olin K. Balch DVM  MS 《Journal of Equine Veterinary Science》1992,12(6):374-381

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Coagulopathic Effects and Therapy of Brodifacoum Toxicosis in Dogs     

Benny J. Woody DVM  MS    Michael J. Murphy DVM  PhD    AIlen C. Ray PhD  Robert A. Green DVM  PhD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1992,6(1):23-28

The clinical signs and laboratory changes of brodifacoum (BDF) intoxicated dogs and their response to vitamin K1 treatment were examined. Brodifacoum, a second-generation anticoagulant rodenticide, was fed to four dogs for 3 consecutive days producing a cumulative dose of 1.1 mg BDF/kg body weight. Clinical observations of the animals were made daily throughout the study. Monitored laboratory parameters included: one-stage prothrombin time (OSPT), activated partial thromboplastin time (APTT), activated coagulation time (ACT), complete blood counts, thrombocyte counts, and serum chemistry values. Response to vitamin K1 therapy was evaluated clinically and by laboratory tests. Serum BDF concentrations were monitored. Inappetence and hemorrhagic tendencies were exhibited by day 5 postrodenticide exposure. One-stage prothrombin time, APTT, and ACT were 25% greater than time zero values at 24, 24, and 72 hours postdosing, respectively. All laboratory parameters returned to normal within 48 hours of initiating vitamin K1 therapy (0.83 mg/kg orally, TID for 5 days). Serum brodifacoum concentrations were highest (1065-1215 ng/mL) during the 3 days after BDF dosing and were detectable (3.0-7.5 ng/mL) until day 24 postexposure. A mean BDF elimination half-life of 6 +/- 4 days was observed.  相似文献   

ULTRASOUND CORNER–HEPATIC PSEUDOMASSES CAUSED BY NORMAL ANATOMIC STRUCTURES IN THE DOG     

William J.  Weber  DVM  Kathy A.  Spaulding  DVM 《Veterinary radiology & ultrasound》1994,35(4):307-309

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Dilated Cardiomyopathy in Juvenile Doberman Pinschers     

Andrea Vollmar DVM  Dipl. ECVIM-CA  Philip R. Fox DVM  MSc  Dipl. ACVIM  ECVIM-CA  Dipl. ACVECC  Kathryn M. Meurs DVM  PhD  Dipl. ACVIM  Si-Kwang Liu DVM  PhD  Dipl. ACVIM 《Journal of Veterinary Cardiology》2003,5(1):637

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Our changing world     

William E. Jones DVM  PhD  Editor 《Journal of Equine Veterinary Science》2003,23(12):514

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Personal CQI Checklists     

Thomas E. Catanzaro DVM  MHA 《Journal of Veterinary Emergency and Critical Care》1994,4(1):41-43

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ULTRASONOGRAPHIC FEATURES OF DIFFUSE HEPATOCELLULAR DISORDERS IN DAIRY CATTLE     

Jezie A.  Acorda  DVM  Magr  Haruo  Yamada  DVM  DVSc  Seyed  Mehdi Ghamsari  DVM 《Veterinary radiology & ultrasound》1994,35(3):196-200

Ultrasonography of the liver was performed in 200 Holstein-Friesian dairy cattle using a 3.5 MHz transducer with a linear array electronic scanner. Liver samples were taken, processed and examined microscopically and the fat occupying rate was calculated. The hepatic ultrasonograms were evaluated according to the presence of bright pattern, dark pattern, deep attenuation, vascular blurring and blurring of edges. Of the 200 animals, 96 had a normal liver, 63 had hydropic degeneration of the liver, 37 had fatty infiltration of the liver, 3 had liver dystrophy and I had hepatic amyloidosis, diagnosed through histopathological examination. Amyloidosis was characterized by bright pattern and blurring of edges. Liver dystrophy had higher percentages of bright pattern and blurring of edges than normal liver. Hydropic degeneration had higher percentages of dark pattern and blurring of edges than normal liver. Fatty infiltration had higher percentages of bright pattern, deep attenuation, vascular blurring and blurring of edges than normal liver. The present results suggest that different ultrasonographic patterns can be observed in various diffuse hepatocellular disorders in dairy cattle  相似文献   

RADIOGRAPHIC FINDINGS OF CANINE DYSAUTONOMIA IN TWENTY-FOUR DOGS     

David A.  Detweiler  David S.  Biller  DVM  James J.  Hoskinson  DVM  Kenneth R.  Harkin  DVM 《Veterinary radiology & ultrasound》2001,42(2):108-112

Canine dysautonomia is an idiopathic condition resulting in loss of autonomic nervous system function. Recently, the prevalence of dogs diagnosed with dysautonomia in the mid-western United States has increased. In this study the medical records and radiographic findings in 24 dogs with dysautonomia were reviewed. A diagnosis of dysautonomia was made in 17 (71%) of the dogs in this study by postmortem examination, the remaining 7 (29%) dogs were diagnosed pharmacologically. The radiographic findings supportive of dysautonomia include aspiration pneumonia, megaesophagus, or a distended stomach, small bowel, or urinary bladder. In some instances, the disease radiographically mimicked other disorders of the gastrointestinal tract, including mechanical obstruction.  相似文献