Infectious diseases. Battling SARS on the frontlines     

Normile D 《Science (New York, N.Y.)》2003,300(5620):714-715

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AN IMPROVED METHOD FOR THE STUDY OF DIFFUSIBLE BACTERIAL PRODUCTS IN VIVO     

Dennis EW 《Science (New York, N.Y.)》1932,76(1982):599-600

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Tropical diseases. Hunt for dengue vaccine heats up as the disease burden grows     

Normile D 《Science (New York, N.Y.)》2007,317(5844):1494-1495

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Disparities in cancer funding     

Dennis PA 《Science (New York, N.Y.)》2004,305(5689):1401-1402

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Alzheimer's disease is a synaptic failure   总被引：1，自引：0，他引：1  

Selkoe DJ 《Science (New York, N.Y.)》2002,298(5594):789-791

In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein.  相似文献   

Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis   总被引：27，自引：0，他引：27  

J W Dennis  S Laferté  C Waghorne  M L Breitman  R S Kerbel 《Science (New York, N.Y.)》1987,236(4801):582-585

Neoplastic transformation has been associated with a variety of structural changes in cell surface carbohydrates, most notably increased sialylation and beta 1-6-linked branching of complex-type asparagine (Asn)-linked oligosaccharides (that is, -GlcNAc beta 1-6Man alpha 1-6Man beta 1-). However, little is known about the relevant glycoproteins or how these transformation-related changes in oligosaccharide biosynthesis may affect the malignant phenotype. Here it is reported that a cell surface glycoprotein, gp 130, is a major target of increased beta 1-6-linked branching and that the expression of these oligosaccharide structures is directly related to the metastatic potential of the cells. Glycosylation mutants of a metastatic tumor cell line were selected that are deficient in both beta 1-6 GlcNAc transferase V activity and metastatic potential in situ. Moreover, induction of increased beta 1-6 branching in clones of a nonmetastatic murine mammary carcinoma correlated strongly with acquisition of metastatic potential. The results indicate that increased beta 1-6-linked branching of complex-type oligosaccharides on gp 130 may be an important feature of tumor progression related to increased metastatic potential.  相似文献   

Women in science. Japanese societies tackle gender issues     

Normile D 《Science (New York, N.Y.)》2002,298(5591):36

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The promise and pitfalls of clinical trials overseas     

Normile D 《Science (New York, N.Y.)》2008,322(5899):214-216

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Tsunami research. Did tsunamis influence Polynesian history?     

Normile D 《Science (New York, N.Y.)》2011,334(6061):1342

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A single IGF1 allele is a major determinant of small size in dogs   总被引：3，自引：0，他引：3  

Sutter NB  Bustamante CD  Chase K  Gray MM  Zhao K  Zhu L  Padhukasahasram B  Karlins E  Davis S  Jones PG  Quignon P  Johnson GS  Parker HG  Fretwell N  Mosher DS  Lawler DF  Satyaraj E  Nordborg M  Lark KG  Wayne RK  Ostrander EA 《Science (New York, N.Y.)》2007,316(5821):112-115

The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant breeds and found marked evidence for a selective sweep spanning a single gene (IGF1), encoding insulin-like growth factor 1. A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.  相似文献