Inhibition of resistance plasmid transfer in Escherichia coli by ionophores, chlortetracycline, bacitracin, and ionophore/antimicrobial combinations     

Mathers JJ  Clark SR  Hausmann D  Tillman P  Benning VR  Gordon SK 《Avian diseases》2004,48(2):317-323

Medicinal feed additives bacitracin, chlortetracycline (CTC), laidlomycin, lasalocid, and salinomycin inhibited the transfer of multiresistance-conferring plasmid pBR325 (Tet(r) Amp(r) Cp(r), 6.0 kb) into selected gram-negative strains with the use of an in vitro model. High concentrations of ampicillin-sensitive competence-pretreated Escherichia coli HB 101 cells were exposed to 10% (v/v) of 1:10 dimethyl sulfoxide/agent : water containing test mixtures for 0.5 hr prior to plasmid addition and transforming conditions. Transformation was inhibited for all antimicrobials and showed a positive association wich higher concentration. Additional testing of ionophore compounds separately and in combination with bacitracin, chlortetracycline, lincomycin, roxarsone, tylosin, and virginiamycin at representative feed concentrations demonstrated 80.6% to >99.9% inhibition (P < 0.001) of resistance transfer. Bacitracin alone inhibited transformation within the range of 50-500 ppm. No increase in resistance transfer was observed when poultry-derived and reference gram-negative isolates having low or no transformation efficiency were additionally tested. The results suggest that these compounds, at relevant concentrations used in animal feed, may interfere with cell envelope-associated DNA uptake channels or other transformation competence mechanisms. Through these mechanisms, ionophores and cell membrane-interactive feed agents such as CTC and bacitracin may act to inhibit resistance transfer mechanisms within poultry and livestock.  相似文献   

Partial carpal and pancarpal arthrodesis in the dog: a review of 50 cases     

H. R. Denny  A. R. S. Barr 《The Journal of small animal practice》1991,32(7):329-334

Fifty-six carpal arthrodeses were carried out in 50 dogs. Six of these had bilateral arthrodeses. A dynamic compression plate (DCP; Straumann Great Britain Ltd), placed on the dorsal aspect of the carpus, was used for fixation in all cases. The main indication for pancarpal arthrodesis was a hyperextension injury of the radiocarpal joint. Forty-three pancarpal arthrodeses were performed in 40 dogs (a bilateral procedure was performed in three). Hyperextension injuries of the intercarpal and carpometacarpal joints were treated by partial carpal arthrodesis in 10 dogs; three of these had bilateral procedures. Seventy-four per cent of dogs treated by pancarpal arthrodesis regained full limb function. Only 50 per cent of cases treated by partial carpal arthrodesis had a similar result.  相似文献   

Surgical treatment of fractures of the olecranon in the horse: a comparative review of 25 cases   总被引：1，自引：0，他引：1  

H R Denny  A R Barr  A Waterman 《Equine veterinary journal》1987,19(4):319-325

A series of 25 horses with olecranon fractures are reviewed. Twenty-one cases were treated surgically by the application of a tension band plate to the caudal aspect of the ulna. Seventy six per cent of these regained full limb function. The results of treatment are compared with two other series of conservatively and surgically treated cases.  相似文献   

Fractures of the accessory carpal bone in the horse     

A R Barr  M J Sinnott  H R Denny 《The Veterinary record》1990,126(17):432-434

The clinical signs and radiographic appearance of 19 cases of fracture of the accessory carpal bone of horses are described. In 17 cases the fractures were in the frontal plane and occurred palmar to the groove on the lateral aspect of the bone. In six cases radiographs taken six months to three years after the fracture occurred showed no evidence of bony union; nevertheless, these and five other horses for which follow-up information was available for up to seven years all became sound, and seven of them returned to competitive activity.  相似文献   

Letters to the editor     

Denny BC 《Science (New York, N.Y.)》1975,187(4182):1145-1148

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The management of bovine fractures: a review of 59 cases     

H R Denny  B Sridhar  B M Weaver  A Waterman 《The Veterinary record》1988,123(11):289-295

Current trends in bovine fracture repair are reviewed with reference to 59 cases. Thirty-one cases were managed surgically, 14 by external fixation, and six by stall confinement. Eight animals were slaughtered without treatment being attempted. A successful outcome was achieved in 90 per cent of the surgically treated cases, compared with 57 per cent for those treated by external fixation methods.  相似文献   

SURGERY     

H.R. Denny 《The Journal of small animal practice》1977,18(11):730-730

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Efficacy of fipronil against ticks     

Denny DJ 《The Veterinary record》2001,148(4):124

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Variation in tree growth characteristics, stress-wave velocity, and Pilodyn penetration of 24-year-old teak (Tectona grandis) trees originating in 21 seed provenances planted in Indonesia     

Fanny Hidayati  Futoshi Ishiguri  Kazuya Iizuka  Kazuko Makino  Yuya Takashima  Sri Danarto  Widaryanti Wahyu Winarni  Denny Irawati  Mohammad Na’iem  Shinso Yokota 《Journal of Wood Science》2013,59(6):512-516

Growth characteristics [stem diameter (D), tree height (H), and bole volume (V)], stress-wave velocity (SWV), and Pilodyn penetration (P) were measured for 21 seed provenances of 24-year-old teak trees planted in Indonesia to characterize variation in tree growth characteristics, SWV, and P among seed provenances. Broad-sense heritability and correlations between the measured characteristics were also determined. Significant differences for all measured characteristics were observed among provenances, indicating that these characteristics are genetically controlled. Broad-sense heritabilities of growth characteristics, SWV, and P are moderate values. These results indicate potential for improving growth characteristics and wood properties of teak trees with the help of breeding programs. Highly significant positive correlations were observed among the growth characteristics, suggesting that they are closely related. In contrast, no significant correlations were observed between the growth characteristics and SWV, indicating that they are independent. We conclude that mechanical properties are also important criteria for selecting plus trees in tree breeding programs. Principal component analysis revealed that seed provenances from Indonesia (Bangilan, Deling, and Randublatung) and India (Malabar and Central Province) have high scores of growth characteristics and SWV.  相似文献   

Biophysics. The intrigue of the interface     

Denny MW 《Science (New York, N.Y.)》2008,320(5878):886

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