Results of Craniotomy for the Treatment of Cerebral Meningioma in 42 Cats     

LORI E. GORDON dvm    CHRISTOPHER THACHER dvm  Dipiomate acvs    DAVID T. MATTHIESEN DVM  Dipiomate ACVS  RICHARD J. JOSEPH DVM  Dipiomate ACVIM 《Veterinary surgery : VS》1994,23(2):94-100

Forty-two cats underwent craniotomy for removal of a meningioma between 1985 and 1991. Median duration of clinical signs before examination was 1.25 months. All cats had inappropriate demeanor: 48% were dull and 38% were lethargic. Neurological deficits included impaired vision in 93%, paresis in 83%, and seizures in 19%. Computed tomography (CT) showed solitary masses in 86% and multiple masses in 14%. Intraoperative complications included hemorrhage and difficulty excising deep or adherent masses. Anemia in 13 of 42 cats was the most common immediate postoperative complication. Ten of 42 cats had no improvement or a more severe neurological status after surgery. Eight of 42 cats died immediately after surgery; 6 of these were anemic. Of the cats that survived the immediate postoperative period, evaluation 10 to 14 days after surgery showed that 97% (33 of 34) were alert and 79% (27 of 34) had returned to normal behavior. Neurological deficits, except for vision impairment, had resolved in most cats. The duration of follow-up varied from 1.3 months to 55.1 months. Ten cats developed neurological abnormalities from 1 month to 44.2 months after surgery; of these, 6 had tumor recurrence or new growth confirmed by CT scan or necropsy. Overall survival was 71% at 6 months, 66% at 1 year, and 50% at 2 years. Age of cat and location of tumor did not significantly affect survival ( P = . 1034 and .1851, respectively). There were too few precise measurements of tumor size to make a valid statistical comparison of the effect of size on survival. Location or presence of multiple tumors did not affect final outcome. Results of this study indicate that surgical excision is a beneficial method of treatment of cranial meningioma in cats.  相似文献   

Distraction Osteogenesis Using Modified External Fixation Devices in Five Dogs     

SUSAN R. YANOFF DVM  MS    DONALD A. HULSE DVM  Dipiomate ACVS    ROSS H. PALMER DVM  MS  Dipiomate ACVS  MICHAEL R. HERRON DVM  MS  Dipiomate ACVS 《Veterinary surgery : VS》1992,21(6):480-487

Distraction osteogenesis was used to treat five dogs with limb deformities or limb shortening. The affected bones underwent osteotomy, and modified external fixators were attached. Complications included pin loosening, implant breakage, and soft-tissue contracture. Adequate limb length was attained in all cases, but clinical results varied from poor to excellent. Two dogs were not lame after the procedure, two dogs had improved function but were still lame, and one dog had complications necessitating amputation.  相似文献   

Arthroscopic Removal of an Osteochondral Fragment from the Middle Phalanx of a Horse     

TIMOTHY B. VAIL DVM  C. WAYNE McILWRAITH BVSc  PhD  FRCVS  Dipiomate ACVS 《Veterinary surgery : VS》1992,21(4):269-272

An intraarticular osteochondral chip fracture of the distal dorsolateral aspect of the right hind middle phalanx in a 4-year-old Dutch Warmblood gelding was removed arthroscopically. Accessibility and visibility of the fragment were excellent, and there was minimal soft tissue trauma.  相似文献   

Thrombolytic Therapy in Dogs and Cats     

Mary F. Thompson BVSc ;    J. Catharine Scott-Moncrieff MA  MS  Vet MB  Dip ACVIM;  Daniel F. Hogan DVM Dip ACVIM 《Journal of Veterinary Emergency and Critical Care》2001,11(2):111-121

Objective: To review the thrombolytic agents most commonly used in humans, their mechanisms of action, potential uses, adverse effects, and reports of their use in dogs and cats.
Human data synthesis: Thrombolytic agents avaliable in human medicine include streptokinase, urokinase, tissueplasminogen activator (t-PA), single-chain urokinase plasma activator (scu-PA) and anisoylated plasminogen-strep-tokinase activator complex (APSAC). These agents were originally used for the management of proximal deep vein thrombosis and severe pulmonary embolism but more recently, use of these drugs has been extended to include the treatment of acute peripheral arterial disease, cerebrovascular disease (stroke) and acute coronary thrombosis. The most predictable side effect associated with the use of thrombolytic therapy is hemorrhage.
Veterinary data synthesis: Clinical experience with thrombolytic agents in small animals is limited to streptokinase and t-PA. It is possible, that as in humans, canine and feline patients with PTE and right ventricular dysfunction may benefit from thrombolytic therapy but there are no veterinary studies to support this theory to date. Successful use of streptokinase has been documented in a small number of canine patients with systemic thromboembolism. ⁶³ Thrombolytic therapy is relatively efficacious in cats with aortic thromboemboli but is associated with a high mortality rate. ^59,60,64 With regard to use of t-PA in veterinary medicine, the small number of animals treated with varying protocols makes it impossible to provide safe and effective dose recommendations at this time.
Conclusions: Future goals for thrombolytic therapy in veterinary medicine include determination of more specific clinical indications, as well as design of effective protocols that minimize mortality and morbidity.  相似文献   

Measurement of Muscle Surface Capillary Blood Flow by Laser Doppler Flowmetry     

WENDY M. NORMAN BVSc    MICHAEL H. COURT BVSc  Dipiomate ACVA    NICHOLAS H. DODMAN BVMS  Dipiomate ACVA  FRANK S. PIPERS DVM  PhD  Dipiomate ACVIM 《Veterinary surgery : VS》1992,21(6):491-493

Muscle surface capillary blood flow was measured in the biceps femoris and lateral head of the triceps brachii muscles in six horses before and during halothane anesthesia by using laser Doppler flowmetry. During 90 minutes of anesthesia, muscle surface capillary blood flow was reduced to 20% to 40% of preanesthetic values. Muscle surface capillary blood flow tended to be lower in dependent muscles than in nondependent muscles, and this disparity was greater in the forelimbs than in the hind limbs.  相似文献   

Intracapsular Subtotal Prostatectomy in Normal Dogs: Use of an Ultrasonic Surgical Aspirator     

CLARENCE A. RAWLINGS DVM  PhD  Diplomate ACVS    WAYNE A. CROWELL DVM  PhD  Diplomate ACVP    JEANNE A. BARSANTI DVM  MS  Diplomate ACVIM  JOHN E. OLIVER Jr  DVM  PhD  Diplomate ACVIM 《Veterinary surgery : VS》1994,23(3):182-189

In an attempt to reduce postoperative incontinence associated with excisional prostatectomy and the recurrence of prostatic disease after less radical surgeries, a new technique for subtotal prostatectomy was developed using an ultrasonic surgical aspirator. During laparotomy, a longitudinal incision was made in the ventral surface of each lobe of the prostate gland. Biopsies for histology and culture were taken. Through the ventral incisions, the ultrasonic surgical aspirator  相似文献   

Regional Perfusion of the Equine Carpus for Antibiotic Delivery     

KAREN J. WHITEHAIR DVM  MS    WILLIAM E. BLEVINS DVM  MS  Dipiomate ACVR    JOHN F. FESSLER DVM  MS  Dipiomate ACVS    DAVID C. VAN SICKLE DVM  PhD    MELVIN R. WHITE DVM  PhD  ROBERT P. BILL DVM  PhD 《Veterinary surgery : VS》1992,21(4):279-285

Regional perfusion of carpal tissues by forced intramedullary administration of fluids was evaluated in 10 horses. Results of subtraction radiography after perfusion with a contrast medium demonstrated that perfusate was delivered to the carpal tissues by the venous system. Perfused India ink was distributed uniformly in the antebrachiocarpal and middle carpal synovial membranes. Histologically, the ink was within the venules of the synovial villi. Immediately after perfusion with gentamicin sulfate (1 g), the gentamicin concentrations in the synovial fluid and synovial membrane of the antebrachiocarpal joint were 349 +/- 240 micrograms/mL and 358 +/- 264 micrograms/g, respectively. When gentamicin concentrations in the synovial fluid of the antebrachiocarpal joint and serum were measured 0, 0.5, 1, 4, 8, 12, and 24 hours after carpal perfusion, the mean peak gentamicin concentration in the synovial fluid was 589 +/- 429 micrograms/mL. At hour 24, the mean gentamicin concentration in the synovial fluid was 4.8 +/- 2.0 micrograms/mL. The resulting peak gentamicin concentration in the serum was 23.7 +/- 14.5 micrograms/mL immediately after the perfusion; it decreased below the desired trough level of 1 micrograms/mL between hours 4 and 8.  相似文献   

Evaluation of Canine-Derived Fibrin Sealant as a Hemostatic Agent   总被引：1，自引：0，他引：1  

LYNN G. WHEATON DVM  Diplomate acvs    RANDY M. GREENSHIELDS dvm    KENNETH MEYERS PhD    K. JANE WARDROP dvm  MS  MICHAEL MOORE DVM  MS  Diplomate ACVIM 《Veterinary surgery : VS》1994,23(5):358-364

The purpose of this study was to determine whether canine-derived fibrinogen concentrate applied with bovine thrombin was a safe and effective topical hemostatic agent. A canine liver biopsy model was selected to test this product. Cryoprecipitate was prepared from frozen canine plasma using two freeze/thaw/centrifugation cycles. Six healthy adult dogs (weighing more than 18 kg) were used in the fibrin sealant study, and an additional three dogs were used as controls for the liver biopsy. A 1 × 3 cm liver biopsy specimen was obtained, digital pressure was applied to reduce bleeding, and the fibrinogen concentrate was immediately sprayed on the bleeding surface simultaneously with bovine thrombin (1,000 IU/mL). The mean ± standard error of the mean (SEM) blood pressure at time of biopsy was 98 ± 9 mm Hg, and the rate of hemorrhage from the cut liver edge was 8.0 ± 1.1 mL/min. The total blood loss during fibrin sealant application was 37 ± 9 mL and total time for hemostasis was 5.5± 1.3 minutes. There was no additional hemorrhage after application of the fibrin sealant. In the three control dogs, fibrin sealant was not applied and only digital compression was used to decrease hemorrhage. Before digital compression, the rate of hemorrhage from the cut liver edge was 13.1 ±3.1 mL/min. Bleeding had not stopped after 10 minutes of compression and the mean postcompression rate of hemorrhage was 4.0 ± 2.6 mL/min. Signs of secondary bleeding after fibrin sealant was applied were not evident during the immediate postoperative period or over the next 14 days. The coagulation profile, alanine amino transferase (ALT), alkaline phosphatase (AP), and bile acids were not significantly different on day 14 from preoperative values, suggesting that the liver was only mildly affected. The dogs were euthanatized and gross and histological examinations of the biopsy site were performed on day 14. There were minimal or no adhesions at the biopsy site. In all dogs, the hepatic capsule was less than 1 mm thick and histological signs of secondary bleeding, hepatocellular damage, thrombosis, infection, or inflammation were not observed. In this study, canine-derived fibrin sealant was a safe and effective topical hemostatic agent.  相似文献   

Evaluation of Direct In Vivo Gene Transfer in an Equine Metacarpal IV Ostectomy Model Using an Adenoviral Vector Encoding the Bone Morphogenetic Protein‐2 and Protein‐7 Gene     

Christopher E. Kawcak DVM  PhD  Diplomate ACVS  Chisa Hidaka MD  C. Wayne Mcilwraith BVSc  PhD  Diplomate ACVS  Natasha Werpy DVM  Diplomate ACVR  Jennifer Macleay DVM  PhD  Diplomate ACVIM  David D. Frisbie DVM  PhD  Diplomate ACVS 《Veterinary surgery : VS》2012,41(3):345-354

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Evaluation of Blind Thoracoscopic‐Assisted Placement of Three Double‐Lumen Endobronchial Tube Designs for One‐Lung Ventilation in Dogs     

Philipp D. Mayhew BVM&S  Diplomate ACVS  William T. N. Culp VMD  Diplomate ACVS  Peter J. Pascoe BVSc  DVA  Diplomate ACVA & ECVAA  Philip H. Kass DVM  MPVM  MS  PhD  Diplomate ACVPM  Lynelle R. Johnson DVM  MS  PhD  Diplomate ACVIM 《Veterinary surgery : VS》2012,41(6):664-670

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