Effect of 5 cm of Water Positive End-Expiratory Pressure on Arterial Oxygen Tension in Dogs During and After Thoracotomy     

TINA RUSTOMJEE BVSc  MS    ANN WAGNER DVM  MS  Diplomate ACVP  Diplomate ACVA  E. CHRISTOPHER ORTON DVM  PhD  Diplomate ACVS 《Veterinary surgery : VS》1994,23(4):307-310

Thoracotomy in dogs often is associated with lower than expected arterial oxygen tensions (PaO₂). Pulmonary collapse from opening the thoracic cavity is likely to be responsible for decreased PaO₂ during thoracotomy. To examine whether positive end-expiratory pressure (PEEP) is beneficial to dogs undergoing thoracotomy, PaO₂ and hemoglobin saturation (SaO₂) were measured in dogs randomly assigned to receive 5 cm of H₂O PEEP (n = 7) or no PEEP (n = 9). During surgery in both groups of dogs, PaO₂ progressively decreased ( P < .001), but the decrease in PaO₂ was significantly less in the PEEP group ( P = .027). In both groups, PaO₂ did not decrease enough to have a substantial effect on SaO₂. Furthermore, application of PEEP during thoracotomy did not prevent moderate hypoxemia after surgery and discontinuation of PEEP. Application of 5 cm of H₂O PEEP seems to attenuate the decrease in PaO₂ observed in dogs undergoing thoracotomy, but routine application of PEEP does not seem justified. ©  相似文献   

The Effect of Occlusive and Semi-Occlusive Dressings on the Healing of Acute Full-Thickness Skin Wounds on the Forelimbs of Dogs     

PAUL W. MORGAN DVM  DVSc    ALLEN G. BINNINGTON DVM  MSc  Diplomate ACVS    CRAIG W. MILLER DVM  MVSc  Diplomate ACVS    DALE A. SMITH DVM  DVSc    ANNE VALLIANT BSc  JOHN F. PRESCOTT MA  Vet MB  PhD 《Veterinary surgery : VS》1994,23(6):494-502

This project compared the effects of hydrocolloid (HC) and hydrogel (HG) occlusive dressings and a polyethylene (PE) semi-occlusive dressing on the healing of acute full-thickness skin wounds on the forelimbs of 10 dogs. All treatments resulted in a similar degree of healing at postoperative days 4 and 7. No significant differences existed in the number of wounds that were more than 90% healed at postoperative day 28 between the group treated with the HG dressing and the group treated with the PE dressing. There were significantly fewer wounds more than 90% healed at postoperative day 28 in the group treated with the HC dressing. Wounds under the HG dressing had the largest mean percentage of contraction at postoperative days 21 and 28. Wounds under the HG dressing also had the largest contraction/re-epithelialization ratio (postoperative days 21 and 28) compared with wounds under the PE and HC dressings. Wounds under the PE dressing had a significantly higher mean percentage of re-epithelialization than wounds under both occlusive dressings on postoperative days 14, 21, and 28. Wounds under the two occlusive dressings had exuberant granulation tissue present more often than wounds under the PE dressing. The two occlusive dressings had significantly higher bacterial counts on wounds compared with wounds under the PE dressing; analysis of variance (ANOVA), P = .0008. Wounds under the HC dressing showed the poorest healing in all parameters.  相似文献   

Effects of Growth Factors and L-Arginine on Ischemic Skin Flaps in Rats     

CHARLES M. WALLS DVM    CLARE R. GREGORY DVM  Diplomate ACVS    L. STEVEN BECK DVM    JOHN P. COOKE MD  PhD    STEPHEN M. GRIFFEY DVM  PHIL H. KASS DVM  PhD 《Veterinary surgery : VS》1995,24(6):484-491

This study determined the effect of the polypeptide growth factors transforming growth factor-beta (TGF-β), insulin-like growth factor-I (IGF-I), and growth hormone (GH) alone and in combination with dietary L-Arginine HCL (ARG) on skin flap survival in rats. Caudally based dorsal skin flaps were created in 110 Sprague-Dawley rats. The rats were randomly assigned into three treatment groups, based on drinking water supplementation. Group 1 (n = 50) received ARG in their drinking water, group 2 (n = 50) received tap water alone, and group 3 (n = 10) received N-omega-nitro-L-arginine (L-NA) and hydralazine. Groups 1 and 2 were divided into subgroups of 10 rats each based on treatment with either: TGF-β, IGF-I, GH, or IGF-I + GH. All subgroups that received GH had significantly greater ( P <.0001) median body weight gains when compared with subgroups not receiving GH. L-arginine HCL when added to IGF-I negated the positive effects of IGF-I on both flap survival and weight gain. Although the rats in all subgroups from groups 1 and 2 had an increase in mean percent skin flap survival when compared with the water alone subgroup, only rats receiving IGF-I, or the combination of ARG with either TGF-β or GH, had statistically significant enhanced skin flap survival. Rats in group 3 did not show an increase in skin flap survival when compared with the control subgroup.  相似文献   

Long-Term Results of Complete and Partial Ligation of Congenital Portosystemic Shunts in Dogs     

HEIDI A. HOTTINGER DVM    RICHARD WALSHAW BVMS  Diplomate ACVS  JOE G. HAUPTMAN DVM  MS  Diplomate ACVS 《Veterinary surgery : VS》1995,24(4):331-336

The medical records of 65 dogs that underwent complete or partial ligation of a single congenital portosystemic shunt (CPSS) were reviewed to determine the long-term clinical results. Information retrieved from the records included age at surgery, preligation (baseline) portal pressure, postligation portal pressure, change in portal pressure from baseline, complete or partial occlusion of the shunting vessel and fasting, and 2-hour postprandial bile acids from the preoperative, early postoperative (PO), and greater than 1 year PO time periods. A clinical rating score derived from a follow-up examination greater than 1 year PO was assigned to each dog. Of the 56 dogs that survived the perioperative period, 29 (52%) had complete and 27 (48%) had partial ligations. Age at surgery, pre- and postligation portal pressure, change in portal pressure from baseline and serum bile acid concentrations were not related to long-term clinical outcome. Clinical rating scores were significantly greater for dogs with partial CPSS ligations compared with dogs with complete ligations, indicating a less favorable clinical outcome for partial ligations. Fasting and 2-hour postprandial bile acid values at both PO time intervals were significantly greater in partial versus complete ligation groups. Follow-up information for more than 1 year was available on 18 of 29 dogs (62%) with complete ligations. All were clinically normal. Of 27 dogs with partial ligations, 11 dogs (41%) developed recurrence of clinical signs resulting in presentation to the university or referring veterinarian for additional surgery, medical management, or euthanasia. Only three dogs with partial CPSS ligation (11%) were clinically normal. Another nine dogs (33%) were operated on again before the possible development of clinical signs and four dogs (15%) were unavailable for follow-up. It was concluded that partial ligation of CPSS is associated with a greater recurrance of clinical signs and patient morbidity than complete ligation.  相似文献   

Nonlymphomatous Hepatobiliary Masses in Cats: 41 Cases (1972 to 1991)     

HOWARD J. LAWRENCE DVM  Diplomate ACVS    HOLLIS N. ERB DVM  PhD  H. JAY HARVEY DVM  Diplomate ACVS 《Veterinary surgery : VS》1994,23(5):365-368

The medical and necropsy records of 41 cats diagnosed with nonlymphomatous hepatobiliary (NLHB) masses, including neoplasia and cysts, were reviewed. Overall, benign masses (n = 27) were more common than malignant ones (n = 14). The single most common malignancy was cholangiocellular carcinoma. The median age at diagnosis was significantly lower ( P < .01) for cats with malignant rather than benign disease. Clinical signs associated with hepatobiliary neoplasia were usually vague and included lethargy, vomiting, and anorexia, often present for at least 2 weeks before presentation. Benign masses were an incidental finding in significantly more ( P < .01) of the cases than were malignant masses. Median values for alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin were significantly higher ( P < .05) in cats with malignant versus benign masses. The prognosis for malignant disease was poor, with 86% of the cats dying or being euthanatized during hospitalization. Cats with benign disease that underwent exploratory celiotomy were more likely to recover and warranted a more favorable prognosis than cats with malignant tumors. Factors associated with malignancy included age at presentation, presence of clinical signs at presentation, and specific serum chemistry changes.  相似文献   

Jejunal Intussusception: A Complication of Functional End-to-End Stapled Anastomoses in Two Ponies     

REBECCA L. FRANKENY VMD    DAVID A. WILSON DVM  MS  Diplomate ACVS    NAT T. MESSER IV DVM  Diplomate ABVP  CYNTHIA CAMPBELL-BEGGS DVM 《Veterinary surgery : VS》1995,24(6):515-517

Jejunojejunal intussusception occurred after jejunal resection and stapled functional end-to-end anastomosis in two pony mares. In both mares, the lead point of the intussusception was the stapled functional end-to-end (FEE) anastomosis. The stapled free ends of jejunum were oversewn with an inverting suture pattern. A possible explanation for development of the intussusception was the acute angle created in the intestine by the FEE anastomsis. This angulation may have impaired flow of ingesta causing motility changes that predisposed the site to intussusception. Because the oversewn blind intestinal ends acted as the lead point for formation of the intussusception, it may be inadvisable to oversew the stapled anastomotic ends.  相似文献   

Vaginourethroplasty for Treatment of Urethral Obstruction in the Bitch   总被引：1，自引：0，他引：1  

R. N. WHITE BSc  BVetMed  CertVA  Diplomate ECVS    J. V. DAVIES BVetMed  PhD  DVR  Diplomate ECVS  S. P. GREGORY BVetMed  PhD  DVR 《Veterinary surgery : VS》1996,25(6):503-510

Vaginourethroplasty was performed in six bitches with infiltrative, obstructive urethral disease. The initial clinical signs included dysuria, hematuria, pollakiuria, and stranguria. Diagnosis was based on the clinical signs, plain radiography and contrast vagino-urethrogram examination, and urethral biopsy. Five dogs were diagnosed as having urethral neoplasia; the sixth dog had granulomatous urethritis. In all six dogs, up to 50% of the urethra and the urethral tubercle were resected to ensure adequate surgical margins. One dog was euthanatized 4 months after surgery for recurrence of a transitional cell carcinoma at the surgical site. Long-term resolution of the problem (minimum of 12 months) was achieved in the other five dogs. The frequency of serious complications, including urinary incontinence and ascending lower urinary tract infections, was low.  相似文献   

HYPERTROPHIC OSTEOPATHY ASSOCIATED WITH PULMONARY BLASTOMYCOSIS IN A DOG   总被引：1，自引：0，他引：1  

Charles W.  Brockus  DVM  John T.  Hathcock  DVM  MS  Diplomate ACVR 《Veterinary radiology & ultrasound》1988,29(4):184-188

Hypertrophic osteopathy (HO) associated with pulmonary blastomycosis was diagnosed in a 5–year-old male mixed-breed dog. One year prior to referral, increased pulmonary opacity had been identified on radiographs made during an examination for a chronic cough. Although serologic tests for blastomycosis were negative, the dog was treated with oral ketoconozole on the basis of suspicious lesions seen on radiographs and clinical signs. Ten months after completing the ketoconozole therapy, the dog was presented for a persistent cough and lameness. Intrapulmonary masses and periosteat proliferation were observed radiographically. A biopsy of the pulmonary masses was done, and Blastomyces dermatitidis was identified. Amphotericin B and ketoconozole administration resulted in clinical improvement and partial resolution of the HO lesions five months after initiation of therapy.  相似文献   

A Comparison of Simple Continuous Versus Simple Interrupted Suture Patterns for Tracheal Anastomosis After Large-Segment Tracheal Resection in Dogs     

ROGER B. FINGLAND DVM  MS  Diplomate ACVS    CANDACE I. LAYTON DVM  MS  Diplomate ACVS    GEORGE A. KENNEDY DVM  PhD  Diplomate ACVP  JOHN C. GALLAND PhD 《Veterinary surgery : VS》1995,24(4):320-330

Two suture techniques for tracheal anastomosis after large-segment tracheal resection were compared. Eight cartilages were resected from the trachea of each of 12 dogs; anastomoses with 4-0 polydioxanone suture were created using a simple continuous suture technique in six dogs and a simple interrupted suture technique in six dogs. Surgical time was shorter but apposition of tracheal segments at the time of surgery was less precise with the simple continuous suture technique. The dogs were evaluated for 150 days after surgery. Clinical abnormalities after tracheal resection and anastomosis were not observed. Percent dorsoventral luminal stenosis was calculated by measuring the tracheal lumen diameter on lateral cervical radiographs. Percent luminal stenosis was calculated planimetrically using a computerized digitizing tablet. Anastomotic stenosis was mild in all dogs; however, the mean percent luminal stenosis determined planimetrically was significantly greater for dogs that had the simple continuous suture technique. Planimetric measurements of cross-sectional area made before and after formalin fixation were not significantly different. Radiographic determination of percent dorsoventral luminal stenosis was a poor predictor of diminution of cross-sectional area determined planimetrically.  相似文献   

Intracapsular Subtotal Prostatectomy in Normal Dogs: Use of an Ultrasonic Surgical Aspirator     

CLARENCE A. RAWLINGS DVM  PhD  Diplomate ACVS    WAYNE A. CROWELL DVM  PhD  Diplomate ACVP    JEANNE A. BARSANTI DVM  MS  Diplomate ACVIM  JOHN E. OLIVER Jr  DVM  PhD  Diplomate ACVIM 《Veterinary surgery : VS》1994,23(3):182-189

In an attempt to reduce postoperative incontinence associated with excisional prostatectomy and the recurrence of prostatic disease after less radical surgeries, a new technique for subtotal prostatectomy was developed using an ultrasonic surgical aspirator. During laparotomy, a longitudinal incision was made in the ventral surface of each lobe of the prostate gland. Biopsies for histology and culture were taken. Through the ventral incisions, the ultrasonic surgical aspirator  相似文献