Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis          下载免费PDF全文

Beatriz P Monteiro  Mary P Klinck  Maxim Moreau  Martin Guillot  Paulo VM Steagall  Daniel K Edge  Jean‐Pierre Pelletier  Johanne Martel‐Pelletier  Dominique Gauvin  Jérôme RE del Castillo  Eric Troncy 《Veterinary anaesthesia and analgesia》2016,43(6):643-651

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Long‐term follow‐up of renal function assessing serum cystatin C in dogs with diabetes mellitus or hyperadrenocorticism          下载免费PDF全文

Sofie J. J. Marynissen  Pascale M. Y. Smets  Liesbeth F. E. Ghys  Dominique Paepe  Joris Delanghe  Sara Galac  Evelyne Meyer  Hervé P. Lefebvre  Sylvie Daminet 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2016,45(2):320-329

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Effects of porcine small intestinal submucosa on elution characteristics of gentamicin-impregnated plaster of Paris     

Seddighi MR  Griffon DJ  Constable PD  Martin-Jimenez T 《American journal of veterinary research》2007,68(2):171-177

OBJECTIVE: To evaluate effects of small intestinal submucosa (SIS) on elution properties of plaster of Paris (POP). SAMPLE POPULATION: 27 POP cylinders, 27 POP spheres, and 9 polymethylmethacrylate (PMMA) spheres. PROCEDURES: Pellets were loaded with gentamicin (50 mg/g) and divided into 7 groups of 9 beads each: PMMA spheres; POP cylinders coated with 0, 4, or 8 layers of SIS; and POP spheres coated with 0, 4, or 8 layers of SIS. Gentamicin concentration was measured 6, 12, 18, 24, 32, 40, and 48 hours and 3, 4, 5, 7, 14, 21, 28, 35, and 42 days after wrapping. Porosity was evaluated via scanning electron microscopy. Curvature factor of elution curves, total amount of drug released (TDR), time required to reach 50% of total release (TDR(t50)), and number of days with concentrations > or = 1 microg/mL were compared among groups. RESULTS: SIS decreased the curvature factor and increased the TDR(t50) and TDR of POP spheres and cylinders. Curvature factor of the PMMA-release curve remained lower than that for any POP group, but all POP groups wrapped in SIS released more gentamicin than PMMA spheres. Gentamicin concentrations remained > or = 1 microg/mL in SIS-wrapped POP and PMMA groups throughout the study. Wrapping POP in SIS minimized the increase in porosity of pellets. CONCLUSIONS AND CLINICAL RELEVANCE: Wrapping POP with SIS slows the release and increases the amount of gentamicin leaching from spheres and cylinders. All groups wrapped in SIS maintained antimicrobial concentrations greater than the minimum inhibitory concentration of most pathogens.  相似文献   

Increased abundance of patatins,lipoxygenase and miraculins in a thaxtomin A-habituated potato Russet Burbank somaclone with enhanced resistance to common scab     

Iauhenia Isayenka  Juan Duque-Yate  Marie-Claire Goulet  Dominique Michaud  Carole Beaulieu  Nathalie Beaudoin 《Plant pathology》2023,72(1):100-111

Potato common scab caused by the actinobacterium Streptomyces scabiei is characterized by the formation of corky lesions on tubers that reduce their marketability. Management of common scab is very complex and often ineffective under various environmental conditions. Using potato varieties that are more resistant to common scab remains one of the most efficient strategies to control this disease. However, very little is known about the factors associated with resistance to common scab. Somaclone RB9 regenerated from thaxtomin A-habituated potato Russet Burbank calli produced tubers more resistant to common scab than the original variety. Comparison of the RB9 tuber proteome with that of Russet Burbank using label-free quantitative proteomic analysis revealed changes in the accumulation of defence-related proteins from the patatin and lipoxygenase (LOX) families, which are involved in the metabolism of lipids, and of two miraculins of the Kunitz-type protease inhibitors family. The implication of LOX during common scab infection was studied using synchronized minitubers developed from leaf-bud cuttings. S. scabiei infection stimulated the accumulation of LOX in both Russet Burbank and RB9 minitubers, but this accumulation was intensified in RB9 minitubers. Infection also increased LOX activity in Russet Burbank and RB9 minitubers. However, LOX activity measured in noninfected RB9 minitubers was similar to that of infected Russet Burbank minitubers, indicating endogenous activation of LOX activity in RB9 minitubers. We discuss how increased LOX abundance and activity in the somaclone RB9 may contribute to improving tuber defence against common scab.  相似文献   

Risk mitigation measures for pesticide runoff: How effective are they?     

Michael Klein  Judith Klein  Jens Flade  Dietlinde Großmann  Dominique Türkowsky  Isabel O'Connor  Simon Spycher  Stefan Reichenberger  Stephan Sittig  Sebastian Multsch  Kai Thomas 《Pest management science》2023,79(12):4897-4905

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Review on estimation of evapotranspiration from remote sensing data: From empirical to numerical modeling approaches   总被引：5，自引：0，他引：5  

Dominique Courault  Bernard Seguin  Albert Olioso 《Irrigation and Drainage Systems》2005,19(3-4):223-249

Different methods have been developed to estimate evapotranspiration from remote sensing data, from empirical approaches such as the simplified relationship to complex methods based on remote sensing data assimilation along with SVAT models. The simplified relationship has been applied from small spatial scale using airborne TIR images to continental scale with NOAA data. Assimilation procedures often require remote sensing data over different spectral domains to retrieve input parameters which characterize surface properties such as albedo, emissivity or Leaf Area Index. A brief review of these different approaches is presented, with a discussion about the main physical bases and assumptions of various models. The paper reports also some examples and results obtained over the experimental area of the Alpilles Reseda project, where various types of models have been applied to estimate surface fluxes from remote sensing data.  相似文献   

Larval traits of the Caribbean amphidromous goby Sicydium punctatum (Gobioidei: Sicydiinae) in Guadeloupe          下载免费PDF全文

Léa Lejeune  Hélène Tabouret  Laura Taillebois  Dominique Monti  Philippe Keith 《Ecology of Freshwater Fish》2016,25(2):272-280

Amphidromous fish are the biggest contributor to the diversity of fish communities in river systems of Caribbean islands. Among them, Sicydium punctatum Perugia, 1896, which is endemic to the West Indies, represents the vast majority of fish in these rivers. The otolith microstructure and the biometry of S. punctatum postlarvae from Guadeloupe were investigated to explore the dispersal modalities of this species through an appreciation of the growth pattern, the pelagic larval duration (PLD) and the size‐at‐recruitment. The study was made on one cohort of 83 recruited postlarvae, fished at the Capesterre River's mouth on 2 November 2011. The mean (±SD) size‐at‐recruitment of the postlarvae was 24.6 ± 1.3 mm (range of 20.5–28.1 mm, n = 83). We found a mean (±SD) PLD of 72.2 ± 10.5 days (range of 54–101.5 days, n = 67). The growth rate estimated from the otolith increments showed a globally decreasing pattern during the marine larval phase. Growth rates at the beginning of the larval stage were significantly different between hatching periods, suggesting a relation between the hatching period and the growth rate in S. punctatum. This study adds on to the general understanding of the life cycle of S. punctatum in Guadeloupe that will help implement strategies to manage amphidromous fish populations in the Caribbean region.  相似文献   

Steroidal saponins from the leaves of Agave macroacantha     

Jacqueline Eskander  Catherine Lavaud  Dominique Harakat 《Fitoterapia》2010,81(5):371-374

A new monodesmosidic spirostanol saponin, along with three known saponins was isolated from Agave macroacantha Zucc leaves. The structure of the new saponin was established as hecogenin-3-O-α-l-rhamnopyranosyl (1→4) β-d-xylopyranosyl (1→3)[β-d-glucopyranosyl (1→2)] β-d-glucopyranosyl (1→4) β-d-galactopyranoside. The ¹H and ¹³C resonances of the four compounds were assigned using a combination of 1D and 2D NMR techniques including ¹H, ¹³C, COSY, TOCSY, ROESY, HSQC and HMBC NMR and confirmed by mass spectrometry.  相似文献   

Cell surfaces in plant micro-organism interactions. VIII. Increased proteinase inhibitor activity in melon plants in response to infection by Colletotrichum lagenarium or to treatment with an elicitor fraction from this fungus     

Dominique Roby  Alain Toppan  Marie-Thrse Esquerr-Tugay 《Physiological and Molecular Plant Pathology》1987,30(3)

Proteinase inhibitor activity had increased sharply in melon seedlings infected by Colletotrichum lagenarium 3 days after inoculation. The activity was associated with heat stable proteins and was effective against the protease produced by the fungus as well as against trypsin. Treatment of healthy melon leaves with an elicitor of ethylene isolated from the pathogen, resulted in a three-fold increase in proteinase inhibitor activity after 24 h. Ethylene production increased early in elicitor-treated leaves and may be involved in the elicitation of proteinase inhibitor activity. In the presence of aminoethoxyvinylglycine, an inhibitor of ethylene biosynthesis, both elicitor-induced ethylene and, to a lesser extent, elicitor-induced proteinase inhibitor activity were inhibited. In contrast, 1-aminocyclopropane-1-carboxylic acid, the direct precursor of ethylene, triggers proteinase inhibitor activity. It is concluded that ethylene is involved in the elicitation of proteinase inhibitor activity, but its exact role remains to be defined.  相似文献   

Medical management of biological warfare and bioterrorism: place of the immunoprevention and the immunotherapy     

Binder P  Attre O  Boutin JP  Cavallo JD  Debord T  Jouan A  Vidal D 《Comparative immunology, microbiology and infectious diseases》2003,26(5-6):401-421

Biological weapons are considered as mass destruction and terror weapons. Terrorism including bioterrorism is the major threat in the future conflicts for our nations. The aim of bioterrorism is more related to the potential disorganisation of the society than to the lethal effects of the agents used. The dramatic consequences cannot be discarded, especially if contagious agents such viral are used. The preparation of specific defence measures is a major challenge for our countries.

The knowledge acquired from the struggle against natural infectious diseases and recent events are essential to improve behaviours to face the biological weapon threats. The defence attitude is based on the anticipation of the threat, the management of the victims, and the restoration of the operational capabilities. This global defence attitude implies six important functions: (i) alert, (ii) detection and diagnosis, (iii) availability of pharmaceutical countermeasures such as vaccine, sera and anti-infectious medicine and products, (iv) medical management of victims, (v) training and information, (vi) research and development.

Passive and active immunoprevention and immuntherapy belong to the approaches discussed in the context of bioterrorism countermeasures. Further researches might be focused on these topics.  相似文献