Infertility associated with the absence of endometrial progesterone receptors in a bitch          下载免费PDF全文

JC Dockweiler  B Cossic  CG Donnelly  RO Gilbert  E Buckles  SH Cheong 《Reproduction in domestic animals》2017,52(1):174-178

A three‐year‐old intact female Old English sheepdog was presented for evaluation of infertility. A uterine biopsy was performed during dioestrus, and the microscopic appearance was inconsistent with progesterone stimulation; the glands were sparse, simple and failed to show coiling, while the glandular epithelium was cuboidal instead of columnar. There was very little evidence of glandular activity. Due to the inappropriate appearance of the glands for the stage of the cycle, immunohistochemistry for progesterone receptors was performed. No progesterone receptor‐positive immunoreactivity was identified in the endometrial luminal epithelium, glandular epithelium or stroma. Weak intranuclear immunoreactivity was identified within the smooth muscle cells of the myometrium. The absence of progesterone receptors within the endometrial glands is the most likely explanation for the abnormal appearance of the endometrium and for this bitch's infertility. To our knowledge, this is the first report of endometrial progesterone receptor absence in a bitch.  相似文献   

Swine fever: the interaction of research and control measures     

J T Done 《The British veterinary journal》1969,125(7):349-353

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Genetic similarity between porcine circovirus type 2 isolated from the first reported case of PMWS in South Africa and North American isolates     

Drew TW  Grierson SS  King DP  Hicks D  Done S  Neser JA  Evans DP  Grimbeek P  Banks M 《The Veterinary record》2004,155(5):149-151

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Congenital splayleg of piglets: myofibrillar hypoplasia   总被引：1，自引：0，他引：1  

D C Thurley  F R Gilbert  J T Done 《The Veterinary record》1967,80(9):302-304

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Surgical and medical management of a uterine spindle cell tumor in an African hedgehog (Atelerix albiventris)     

Lisa B Done  Sharon L Deem  Christine V Fiorello 《Journal of zoo and wildlife medicine》2007,38(4):601-603

A 5-yr-old female African hedgehog (Ateleris albiventris) presented with hematuria. Vulvar culture results revealed a 4+ growth of Enterococcus sp. and gamma-Streptococcus sp. susceptible to trimethoprim sulfa and enrofloxacin. Ultrasound evaluation of the abdomen revealed an unidentifiable tubular structure in the region of the reproductive tract. An exploratory laparotomy and ovariohysterectomy were performed. Pathologic studies of the uterus showed a uterine spindle cell tumor, uterine endometrial polyp, uterine adenomyosis, and a possible acute infarct resulting in uterine wall necrosis. Hematuria did not reoccur, and the hedgehog lived for another 19 mo until she died from an oral squamous cell carcinoma. To date, this is the first report of a uterine spindle cell tumor in an African hedgehog.  相似文献   

The growth of the cerebellum in the foetal pig   总被引：3，自引：0，他引：3  

J T Done  C N Hebert 《Research in veterinary science》1968,9(2):143-148

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Pseudomonas aeruginosa infection in the skin of a dog: a case report     

S H Done 《The British veterinary journal》1974,130(4):lxviii-lxlxix

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Porcine dermatitis and nephropathy syndrome. clinical and pathological features of cases in the United Kingdom (1993-1998)     

Thomson JR  Higgins RJ  Smith WJ  Done SH 《Journal of veterinary medicine. A, Physiology, pathology, clinical medicine》2002,49(8):430-437

This paper documents the salient clinical and pathological features of porcine dermatitis and nephropathy syndrome (PDNS) in 96 pigs submitted from 55 units in the UK from 1993 to 1998. This series of cases pre-dated the emergence of post-weaning multisystemic wasting syndrome (PMWS) in the UK. The morbidity during outbreaks was 1% or less. Affected pigs ranged from 14 to 70 kg in weight and most died after a short clinical illness. Fifty-five pigs had multifocal or coalescing erythematous skin lesions, some progressing to dermal necrosis. Biochemistry showed raised serum urea, creatinine and gamma globulin levels accompanied by proteinuria. All cases showed bilateral renal enlargement with petechiae throughout the cortices. Microscopically these renal lesions ranged in chronology from acute necrotizing glomerulitis and vasculitis with multiple hyaline casts in renal tubules to chronic glomerular sclerosis with interstitial inflammation and fibrosis. Haemorrhagic dermatitis when present was associated with necrotizing vasculitis in the dermal vessels. Vasculitis was sometimes detected in other tissues including subcutis, lymph nodes, spleen, liver, joint synovial membrane, gastric and intestinal submucosa or serosa and meninges but its frequency and distribution varied considerably in individual pigs. Immunostaining showed deposits of IgG and IgM in damaged glomeruli, renal casts and skin lesions. The aetiology and pathogenesis of the condition remain unknown but the histopathological and immunological findings suggest a systemic immune-complex disorder resulting in vasculitis with particular predilection for kidney and skin.  相似文献   

Endotracheal intubation and injury to the tracheal epithelium in the pig     

S H Done 《Research in veterinary science》1971,12(1):91-92

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Effects of Supplementing Holstein Heifers with Dietary Melatonin during Late Gestation on Growth and Cardiovascular Measurements of their Offspring          下载免费PDF全文

KE Brockus  CG Hart  BO Fleming  T Smith  SH Ward  CO Lemley 《Reproduction in domestic animals》2016,51(2):240-247

The objective was to examine the effects of supplementing dams with dietary melatonin during late gestation on offspring growth and cardiovascular measurements. On day 190 of gestation, heifers (n = 20) were blocked by body weight and randomly assigned to one of two dietary treatments consisting of 20 mg of dietary melatonin per day [melatonin (MEL)] or no melatonin supplementation [control (CON)]. Dietary treatments were terminated on day 262 of gestation. At birth, calves were separated from their dams with no further treatments. Calf (n = 18) blood pressure, cortisol, nitrites and total antioxidant capacity were collected on weeks 0, 1, 2, 3 and 4 of age. Calf hepatic portal blood flow and concentrations of insulin‐like growth factor 1 were determined on weeks 0 and 4 of age. Calf body weight, abdominal girth, hip height and wither height increased (p < 0.05) with age. An age by treatment interaction (p < 0.01) was observed for calf body weight, which was increased at weeks 8 and 9 of age in calves born to MEL heifers compared to calves born to CON heifers. Pulse pressure, mean arterial pressure, absolute hepatic portal blood flow and blood flow relative to calf body weight were not different (p > 0.05) between treatments. A main effect of calf age (p < 0.05) was observed for concentrations of insulin‐like growth factor 1, which was decreased at week 4 compared to week 0. An age by treatment interaction (p < 0.05) was observed for cortisol, which was decreased at week 2 in calves from MEL‐treated dams compared to calves from CON‐treated dams. Early post‐natal growth was altered in offspring born to dams supplemented with dietary melatonin. This could lead to further foetal programming implications in conjunction with post‐natal development.  相似文献