Clear air turbulence: a mystery may be unfolding   总被引：1，自引：0，他引：1  

Dutton JA  Panofsky HA 《Science (New York, N.Y.)》1970,167(3920):937-944

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Early Cleavage of Handmade Cloned Buffalo (Bubalus bubalis) Embryos is an Indicator of Their Developmental Competence and Quality          下载免费PDF全文

S Kaith  M Saini  AK Raja  AA Sahare  B Jyotsana  P Madheshiya  P Palta  MS Chauhan  RS Manik  SK Singla 《Reproduction in domestic animals》2015,50(2):214-220

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Antigen receptor molecules: inhibition by antiserum against kappa light chains   总被引：8，自引：0，他引：8  

J Lesley  R W Dutton 《Science (New York, N.Y.)》1970,169(944):487-488

Rabbit antiserum against mouse kappa chains, the predominant class of light chains found in mouse immunoglobulins, inhibits the immune response in vitro of mouse spleen cells to erythrocyte antigens. The inhibition becomes irreversible if the mouse spleen cells are treated briefly with both antiserum to kappa chains and complement.  相似文献   

Biology, Medicine, and Surgery of Elephants     

Christopher J. Dutton 《The Canadian veterinary journal. La revue veterinaire canadienne》2008,49(1):45

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Corpus Luteum–Endometrium–Embryo Interactions in the Dairy Cow: Underlying Mechanisms and Clinical Relevance     

RS Robinson  AJ Hammond  DC Wathes  MG Hunter  GE Mann 《Reproduction in domestic animals》2008,43(S2):104-112

Conception rates of dairy cows are currently declining at an estimated 1% every year. Approximately, 35% of embryos fail to prevent luteolysis during the first three weeks of gestation. Interactions between the corpus luteum, endometrium and embryo are critical to the successful establishment of pregnancy and inadequacies will result in the mortality of the embryo. For example, as little as a one day delay in the post-ovulatory rise of progesterone has serious consequences for embryo development and survival. Recently, we found that LH support, degree of vascularization and luteal cell steroidogenic capacity were not the major factors responsible for this luteal inadequacy, but are nevertheless essential for luteal development and function. Progesterone acting on its receptor in the endometrium stimulates the production of endometrial secretions on which the free-living embryo is dependent. However, their exact composition and effects of inadequate progesterone remains to be determined. The embryo is recognized through its secretion of interferon tau (IFNT), which suppresses luteolytic pulses of prostaglandin F_2α. In the cow, it is most likely that IFNT inhibits oxytocin receptor up-regulation directly and does not require the prior inhibition of oestrogen receptor α (ESR1). Unravelling the precise luteal-endometrium and embryo interactions is essential for us to understand pregnancy establishment and development of strategies to reverse the declining fertility of dairy cows.  相似文献   

An update on canine cardiomyopathies – is it all in the genes?          下载免费PDF全文

E. Dutton  J. López‐Alvarez 《The Journal of small animal practice》2018,59(8):455-464

Dilated cardiomyopathy is the second most common cardiac disease in dogs and causes considerable morbidity and mortality. Primary dilated cardiomyopathy is suspected to be familial, and genetic loci have been associated with the disease in a number of breeds. Because it is an adult‐onset disease, usually with late onset, testing breeding dogs and bitches before breeding for a genetic mutation that could lead to dilated cardiomyopathy would be helpful to prevent disease. There is growing evidence that the genetic basis may be multigenic rather than monogenic in the majority of studied breeds. This review article describes the known genetic aspects of canine dilated cardiomyopathy and the implications of genetic tests on heart testing and the future of veterinary cardiology.  相似文献   

Comparison of intradermal testing and serum testing for allergen-specific IgE using monoclonal IgE antibodies in 84 atopic dogs     

RS MUELLER  A. BURROWS  J. TSOHALIS 《Australian veterinary journal》1999,77(5):290-294

OBJECTIVE: To compare an ELISA measuring serum allergen-specific IgE with intradermal skin testing in canine atopic dermatitis. PROCEDURE: Eighty-four dogs with the clinical diagnosis of atopic dermatitis underwent intradermal skin testing and serum testing for allergen-specific IgE. Tests were performed in a blinded fashion. Positive reactions were compared and the sensitivity and specificity of the serum test (using intradermal skin test as the standard) were determined overall and for individual allergen groups (grass pollens, weed pollens, tree pollens, house dust mites and fleas). RESULTS: The sensitivity of the ELISA overall was 90.4%. Evaluating the individual allergen groups, the sensitivity for dust mite hypersensitivity was 95.1%, for fleas 85.4%, for tree pollens 84.3%, for grass pollens 95.1% and for weed pollens 96.4%. The specificity was 91.6% overall, for dust mites 96.3%, for fleas 92.7%, for tree pollens 95.2%, for grass pollens 94% and for weed pollens 80.7%. CONCLUSION: The evaluated ELISA seemed reliable for the diagnosis of atopy in practice and can be recommended as a screening test prior to intradermal skin testing or for use in dogs when immunotherapy is not a therapeutic option.  相似文献   

Preoperative factors associated with hypotension in young anaesthetised dogs undergoing elective desexing          下载免费PDF全文

RS Costa  AL Raisis  G Hosgood  GC Musk 《Australian veterinary journal》2015,93(4):99-104

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The Calyptogena magnifica chemoautotrophic symbiont genome     

Newton IL  Woyke T  Auchtung TA  Dilly GF  Dutton RJ  Fisher MC  Fontanez KM  Lau E  Stewart FJ  Richardson PM  Barry KW  Saunders E  Detter JC  Wu D  Eisen JA  Cavanaugh CM 《Science (New York, N.Y.)》2007,315(5814):998-1000

Chemoautotrophic endosymbionts are the metabolic cornerstone of hydrothermal vent communities, providing invertebrate hosts with nearly all of their nutrition. The Calyptogena magnifica (Bivalvia: Vesicomyidae) symbiont, Candidatus Ruthia magnifica, is the first intracellular sulfur-oxidizing endosymbiont to have its genome sequenced, revealing a suite of metabolic capabilities. The genome encodes major chemoautotrophic pathways as well as pathways for biosynthesis of vitamins, cofactors, and all 20 amino acids required by the clam.  相似文献   

The persistently variable "background" stratospheric aerosol layer and global climate change     

Solomon S  Daniel JS  Neely RR  Vernier JP  Dutton EG  Thomason LW 《Science (New York, N.Y.)》2011,333(6044):866-870

Recent measurements demonstrate that the "background" stratospheric aerosol layer is persistently variable rather than constant, even in the absence of major volcanic eruptions. Several independent data sets show that stratospheric aerosols have increased in abundance since 2000. Near-global satellite aerosol data imply a negative radiative forcing due to stratospheric aerosol changes over this period of about -0.1 watt per square meter, reducing the recent global warming that would otherwise have occurred. Observations from earlier periods are limited but suggest an additional negative radiative forcing of about -0.1 watt per square meter from 1960 to 1990. Climate model projections neglecting these changes would continue to overestimate the radiative forcing and global warming in coming decades if these aerosols remain present at current values or increase.  相似文献