Efficacy and safety of a purified porcine insulin zinc suspension for managing diabetes mellitus in dogs     

Monroe WE  Laxton D  Fallin EA  Richter KP  Santen DR  Panciera DL  Towell TL  Williams KA  Hart JR  Hill S  Finkler MR  Shinn JS 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(5):675-682

The objective of this study was to evaluate the safety and efficacy of a purified porcine insulin zinc suspension for treating dogs with uncomplicated diabetes mellitus. Fifty-three dogs were treated for 60 days after an initial dose determination period. The means of the blood glucose concentrations during 12-hour glucose curves and the means of the blood glucose nadir concentrations during 12-hour glucose curves for all dogs were determined before beginning insulin therapy (time 0), at the end of the dose determination period (time 1), 30 days after time 1 (time 2), and 60 days after time 1 (time 3). Presence of polyuria, polydipsia, and ketonuria was determined at each time point. Adequacy of control of hyperglycemia was based on 12-hour blood glucose curves and improvement in clinical variables (results of physical examinations, historic information, polyuria, polydipsia, and ketonuria). Safety was evaluated by questionnaire, performance of physical examination, CBC, serum chemistry profile, and urinalysis. The means of the blood glucose concentrations during 12-hour glucose curves and the means of the blood glucose nadir concentrations during 12-hour glucose curves for all dogs at times 1, 2, and 3 were significantly lower compared with time 0 (P < .0001). There was a reduction in the proportion of dogs with polyuria, polydipsia, and ketonuria of 82, 86, and 80%, respectively. All of the dogs had adequate glycemic control at time 1, 66% at time 2, and 75% at time 3. At time 3, 66% of dogs required insulin injections q12h. Other than hypoglycemia, there were no important adverse effects of insulin administration. The insulin, was safe and efficacious for reducing blood glucose and clinical signs in dogs with diabetes mellitus.  相似文献   

Contributions on the diagnosis of tuberculosis in horses. 3. Tuberculin tests in experimentally infected horses     

W Richter 《Archiv fuer experimentelle veterinaermedizin》1967,21(5):1235-1251

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Haptoglobin in domestic mammals. III. Haptoglobin content in blood plasma and serum in ruminants and pigs under various physiological conditions     

H Richter 《Archiv fuer experimentelle veterinaermedizin》1974,28(4):505-519

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Unified system of accounting and statistics in the veterinary profession     

W Richter  G Assmann 《Monatshefte für Veterin?rmedizin》1970,25(12):466-469

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Evaluation of therapeutic success in spavin of trotting horses with the aid of performance criteria     

O Dietz  J Mill  W Richter 《Monatshefte für Veterin?rmedizin》1969,24(15):579-586

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Haptoglobin in domestic mammals. II. Quantitative haptoglobin determination in blood serum and plasma by various methods     

H Richter  D Wagner 《Archiv fuer experimentelle veterinaermedizin》1974,28(4):491-503

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Preoperative and postoperative hemostatic profiles of dogs undergoing ovariohysterectomy.     

D L Millis  J G Hauptman  M Richter 《The Cornell veterinarian》1992,82(4):465-470

Hemostatic profiles were evaluated in 15 healthy dogs immediately before and 24 hours after celiotomy for routine ovariohysterectomy. Prothrombin time, activated partial thromboplastin time, fibrinogen, fibrin degradation products, antithrombin III activity, platelet count, and hemogram were measured. There were no significant changes in prothrombin time, activated partial thromboplastin time, fibrin degradation products, antithrombin III activity, or platelet count. Fibrinogen concentration was significantly higher following surgery. Postoperative leukocyte differential counts were typical of stress leukograms, and were characterized by leukocytosis, neutrophilia, lymphopenia and eosinopenia. Mild decreases in packed cell volume, red blood cell count and hemoglobin concentration were consistent with minor blood loss during surgery or fluid retention and hemodilution postoperatively. It was concluded that celiotomy and routine ovariohysterectomy in healthy dogs did not alter hemostatic profiles 24 hours after surgery. Abnormal postoperative hemostatic profiles should not be attributed to surgery alone; other causes of abnormal hemostatic profiles should be investigated.  相似文献   

Contributions on tuberculosis diagnosis in horses. II. Hematologic studies     

W Richter 《Archiv fuer experimentelle veterinaermedizin》1966,20(3):477-487

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Data evaluation in the District of Potsdam Pig Health Service by means of computers     

H D Dannenberg  W Richter 《Monatshefte für Veterin?rmedizin》1966,21(14):533-536

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Plasma haptoglobin concentration in cattle with surgically corrected torsio uteri intrapartum     

Schönfelder A  Schrödl W  Krüger M  Richter A  Sobiraj A 《Berliner und Münchener tier?rztliche Wochenschrift》2006,119(1-2):81-85

In 26 cows with surgically corrected torsio uteri intra partum, severity of disease, wound healing and secondary diseases were correlated with plasma haptoglobin concentration. The objective of the investigation was to determine, if an increased plasma haptoglobin concentration indicates the severity of disease respectively expected wound healing disorders or secondary diseases. The degree of severity of disease was determined by rectally diagnosed elasticity of the uterus before the surgery. In the present investigation, the severity of a uterine torsion intra partum could not be evaluated by determining the plasma haptoglobin concentration. In 9 of 11 days of investigation there was no significant difference in the plasma haptoglobin concentration of animals with an elastic uterus (animals with good prognosis) in contrast to cows with tight uterus (patients with poor prognosis) found. The significant differences on the 6th and 7th day post surgery are related to secondary diseases in patients with poor prognosis, which develop evidently earlier and form stronger. The correlation of all cows with--to those without secondary illnesses shows, that 10 days post surgery patients with secondary diseases have a significant higher plasma haptoglobin concentration (p < 0.05) compared to animals without secondary illnesses. No correlations existed between plasma haptoglobin concentration and wound healing in the examined cattle. A postoperatively increase of haptoglobin indicates a higher risk of secondary illnesses and complications.  相似文献