Protocol changes to reduce implant‐associated infection rate after tibial plateau leveling osteotomy: 703 dogs, 811 TPLO (2006‐2014)          下载免费PDF全文

Samantha L. Stine DVM  Susan M. Odum PhD  W. Daniel Mertens DVM  Diplomate ACVS 《Veterinary surgery : VS》2018,47(4):481-489

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Evaluation of the rostral projection of the sacral lamina as a component of degenerative lumbosacral stenosis in German shepherd dogs          下载免费PDF全文

Harvey Saunders BVSc  Andrew J. Worth BVSc  PhD  FANZCVS  Janis P. Bridges BSc  GradDip Appl Stat  Angela Hartman DVM  DipACVR 《Veterinary surgery : VS》2018,47(5):654-663

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Pharmacokinetics and effects of alfaxalone after intravenous and intramuscular administration to cats     

D Rodrigo-Mocholí  E Escudero  E Belda  FG Laredo  V Hernandis 《New Zealand veterinary journal》2018,66(4):172-177

AIMS: To determine the pharmacokinetics, and anaesthetic and sedative effects of alfaxalone after I/V and I/M administration to cats.

METHODS: Six European shorthair cats, three males and three females, with a mean weight of 4.21 (SD 0.53) kg and aged 3.8 (SD 0.9) years were enrolled in this crossover, two–treatment, two-period study. Alfaxalone at a dose of 5?mg/kg was administered either I/V or I/M. Blood samples were collected between 2–480 minutes after drug administration and analysed for concentrations of alfaxalone by HPLC. The plasma concentration-time curves were analysed by non-compartmental analysis. Sedation scores were evaluated between 5–120 minutes after drug administration using a numerical rating scale (from 0–18). Intervals from drug administration to sit, sternal and lateral recumbency during the induction phase, and to head-lift, sternal recumbency and standing position during recovery were recorded.

RESULTS: The mean half-life and mean residence time of alfaxalone were longer after I/M (1.28 (SD 0.21) and 2.09 (SD 0.36) hours, respectively) than after I/V (0.49 (SD 0.07) and 0.66 (SD 0.16) hours, respectively) administration (p<0.05). Bioavailability after I/M injection of alfaxalone was 94.7 (SD 19.8)%. The mean intervals to sternal and lateral recumbency were longer in the I/M (3.73 (SD 1.99) and 6.12 (SD 0.90) minutes, respectively) compared to I/V (0 minutes for all animals) treated cats (p<0.01). Sedation scores indicative of general anaesthesia (scores >15) were recorded from 5–15 minutes after I/V administration and deep sedation (scores 11–15) at 20 and 30 minutes. Deep sedation was observed from 10–45 minutes after I/M administration. One cat from each group showed hyperkinesia during recovery, and the remainder had an uneventful recovery.

CONCLUSIONS AND CLINICAL RELEVANCE: Alfaxalone administered I/V in cats provides rapid and smooth induction of anaesthesia. After I/M administration, a longer exposure to the drug and an extended half life were obtained compared to I/V administration. Therefore I/M administration of alfaxalone could be a reliable, suitable and easy route in cats, taking into account that alfaxalone has a slower onset of sedation than when given I/V and achieves deep sedation rather than general anaesthesia.  相似文献   

Incidence and risk factors of surgical site infection and septic arthritis after elective arthroscopy in horses          下载免费PDF全文

Julie Y. Brunsting DVM  Frederik J. Pille DVM  PhD  Diplomate ECVS  Maarten Oosterlinck DVM  PhD  Diplomate ECVS  Maarten Haspeslagh DVM  Hans C. Wilderjans DVM  Diplomate ECVS 《Veterinary surgery : VS》2018,47(1):52-59

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Phrenicoabdominal venotomy for tumor thrombectomy in dogs with adrenal neoplasia and suspected vena caval invasion          下载免费PDF全文

Philipp D. Mayhew BVM&S  DACVS  William T. N. Culp VMD  DACVS  Ingrid M. Balsa DVM  Allison L. Zwingenberger DVM  MAS  DACVR  DECVDI 《Veterinary surgery : VS》2018,47(2):227-235

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Perceptions and opinions of pet owners in the United Sates about surgery,pain management,and anesthesia in dogs and cats          下载免费PDF全文

Bradley T. Simon DVM  MSc  DACVAA  Elizabeth M. Scallan DVM  MBA  MS  CVA  CCRP  Dirsko J. F. Von Pfeil DVM  DACVS  DECVS  DACVSMR  Daniel T. Boruta DVM  DACVAA  Rick Wall DVM  DACVSMR  CCRP  Belle M. Nibblett DVM  MVSc  DACVIM  O Odette DVM  DACVAA  Guy Beauchamp PhD  Paulo V. Steagall DVM  MSc  PhD  DACVAA 《Veterinary surgery : VS》2018,47(2):277-284

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Removal of hemangiosarcoma cells from canine blood with a cell salvage system and leukocyte reduction filter          下载免费PDF全文

Brittany Ciepluch DVM  MS  Heather Wilson‐Robles DVM  DACVIM  Gwendolyn Levine DVM  DACVP  Roger Smith DVM  PhD  Gus A. Wright PhD  Tasha Miller BS  Maureen T. O'Brien DVM  MS  DACVP  Kelley M. Thieman Mankin DVM  MS  DACVS‐SA 《Veterinary surgery : VS》2018,47(2):293-301

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A profile of morbidity and mortality rounds within resident training programs of the American College of Veterinary Surgeons          下载免费PDF全文

Philip J. Kieffer DVM  P. O. Eric Mueller DVM  PhD  DACVS 《Veterinary surgery : VS》2018,47(3):343-349

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Total prostatectomy as a treatment for prostatic carcinoma in 25 dogs          下载免费PDF全文

Tristram C. Bennett BVSc  MANZCVS  Francesco Collivignarelli DVM  MS  Paolo Buracco DVM  DECVS 《Veterinary surgery : VS》2018,47(3):367-377

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In vitro evaluation of a simulated pneumoperitoneum environment using carbon dioxide on canine transitional cell carcinoma          下载免费PDF全文

Rashi Asthana MSc  Michelle L. Oblak DVM  DVSc  Diplomate ACVS  ACVS Fellow of Surgical Oncology  Ameet Singh DVM  DVSc  Diplomate ACVS 《Veterinary surgery : VS》2018,47(3):412-420

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