Evaluation of an automated dual-channel hydroxylamine assay procedure for formulated penicillin products. II. Intact solid dosage formulations     

J R Lane 《Journal of the Association of Official Analytical Chemists》1974,57(6):1325-1337

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Comparative effectiveness of certain knife disinfectants and the use of the double-edged knife for the control of ring rot of potatoes     

W. A. Kreutzer  Geo H. Lane  J. L. Paschal 《American Journal of Potato Research》1946,23(8):291-299

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Polyclonal antibody–based immunohistochemical detection of intraleukocytic Theileria parasites in roan and sable antelopes     

Sarah J. Clift  Bernat Martí-Garcia  Rephima M. Phaswane  Emily P. Mitchell  Antoinette I. Josemans  Ilse Vorster  Katja N. Koeppel  Jeanni Fehrsen 《Journal of veterinary diagnostic investigation》2021,33(6):1079

Theileria parasites commonly infect African wild artiodactyls. In rare roan (Hippotragus equinus) and sable (H. niger) antelopes, Theileria sp. (sable)-associated calf mortalities constrain breeding programs. The pathogenicity of most leukocyte-transforming Theileria spp. originates in their invasion of and multiplication in various mononuclear leukocytes, the transformation of both infected and uninfected leukocytes, and their infiltration of multiple organs. Understanding the pathogenesis of theileriosis can be improved by the use of immunohistochemistry (IHC) to identify the localization of the parasites in tissue sections. Our aim was to develop a reproducible IHC assay to detect leukocyte-associated Theileria parasites in formalin-fixed, paraffin-embedded roan and sable tissues. Polyclonal antibodies were purified from the sera of 5 roans from an area endemic for Theileria sp. (sable) and tested for IHC reactivity in 55 infected and 39 control roan and sable antelopes, and for antigen and species cross-reactivity in an additional 58 cases. The 3 strongest antibodies consistently detected intraleukocytic theilerial antigens in known positive cases in roan and sable antelopes, and also detected other Theileria spp. in non-hippotraginid wild artiodactyl tissues. The antibodies did not cross-react with other apicomplexan protozoa, with the exception of Cryptosporidium. Given that PCR on its own cannot determine the significance of theilerial infection in wild ruminants, IHC is a useful laboratory test with which to confirm the diagnosis in these species.  相似文献   

Prospective study of dilated cardiomyopathy in dogs eating nontraditional or traditional diets and in dogs with subclinical cardiac abnormalities     

Lisa Freeman  John Rush  Darcy Adin  Kelsey Weeks  Kristen Antoon  Sara Brethel  Suzanne Cunningham  Luis Dos Santos  Renee Girens  Robert Goldberg  Emily Karlin  Darleen Lessard  Katherine Lopez  Camden Rouben  Michelle Vereb  Vicky Yang 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2022,36(2):451

BackgroundRecent studies have investigated dogs with presumed diet‐associated dilated cardiomyopathy (daDCM), but prospective studies of multiple breeds are needed.Hypothesis/ObjectivesTo evaluate baseline features and serial changes in echocardiography and cardiac biomarkers in dogs with DCM eating nontraditional diets (NTDs) or traditional diets (TDs), and in dogs with subclinical cardiac abnormalities (SCA) eating NTD.AnimalsSixty dogs with DCM (NTD, n = 51; TDs, n = 9) and 16 dogs with SCA eating NTDs.MethodsEchocardiography, electrocardiography, and measurement of taurine, cardiac troponin I, and N‐terminal pro‐B‐type natriuretic peptide were performed in dogs with DCM or SCA. Diets were changed for all dogs, taurine was supplemented in most, and echocardiography and cardiac biomarkers were reassessed (3, 6, and 9 months).ResultsAt enrollment, there were few differences between dogs with DCM eating NTDs or TDs; none had low plasma or whole blood taurine concentrations. Improvement in fractional shortening over time was significantly associated with previous consumption of a NTD, even after adjustment for other variables (P = .005). Median survival time for dogs with DCM was 611 days (range, 2‐940 days) for the NTD group and 161 days (range, 12‐669 days) for the TD group (P = .21). Sudden death was the most common cause of death in both diet groups. Dogs with SCA also had significant echocardiographic improvements over time.Conclusions and Clinical ImportanceDogs with DCM or SCA previously eating NTDs had small, yet significant improvements in echocardiographic parameters after diet changes.  相似文献   

Bee communities in forestry production landscapes: interactive effects of local-level management and landscape context     

Miljanic  Andriana S.  Loy  Xingwen  Gruenewald  David L.  Dobbs  Emily K.  Gottlieb  Isabel G. W.  Fletcher  Robert J.  Brosi  Berry J. 《Landscape Ecology》2019,34(5):1015-1032

Landscape Ecology - Land-use change is a key driver of pollinator declines worldwide. Plantation forests are a major land use worldwide and are likely to expand substantially in the near term,...  相似文献   

Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia     

Melissa A. Mercer  Jennifer L. Davis  Harold C. McKenzie  Kristen M. Messenger  Emily Schaefer  R. McAlister Council-Troche  Stephen R. Werre 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(2):718-727

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Potential of blended organic acids to improve performance and health of broilers infected with necrotic enteritis     

Alip Kumar  Mehdi Toghyani  Sarbast K. Kheravii  Lane Pineda  Yanming Han  Robert A. Swick  Shu-Biao Wu 《动物营养（英文）》2021,7(2):440

Organic acids (OA) and their blends have been shown to positively affect performance and health of broilers. However, the data in the literature are not consistent. This study examined the potential of blended short-chain fatty acids (SCFA) with medium-chain fatty acids (MCFA) as alternatives to antibiotic growth promoters (AGP) on performance, health and welfare of broilers infected with necrotic enteritis (NE). The additives used were: A) a blend of SCFA, MCFA, and a phenolic compound (SMP); B) a blend of free and buffered SCFA with MCFA (SMF); C) a blend of free and buffered SCFA with a high concentration of MCFA (SHM). A total of 1,404 Ross 308 one-day-old male parental chicks were randomly distributed into 78-floor pens with 13 replicates of 18 birds each. Six treatments were the following: T1, unchallenged control (UCC); T2, challenged control (CHC); T3, challenged group plus zinc bacitracin (BAC); T4, challenged group plus additive SMP; T5, challenged group plus additive SMF; T6, challenged group plus additive SHM. Challenged birds were gavaged with Eimeria spp. on d 9 and Clostridium perfringens EHE-NE18 on d 14. Post NE challenge and cumulatively, BWG, FCR, and nutrient digestibility of birds were compromised (P < 0.05) by NE challenge indicating a successful induction of sub-clinical NE. Additive SHM had higher BWG compared to CHC and BAC groups (P = 0.001; d 10 to 24) but not different from SMP and SMF groups (P > 0.05). All the 3 additive groups had lower FCR compared to CHC (P = 0.001; d 0 to 35), and exhibited similar jejunal lesions (d 16) compared to BAC and apparent ileal protein digestibility (d 21) compared to UCC and BAC groups (P > 0.05). Birds in additive SHM group had a higher concentration of serum IgA compared to all groups (P = 0.001) except additive SMF (P > 0.05; d 21). All the additive groups had lower footpad dermatitis and hock burns compared to CHC (P < 0.05). The findings suggest the potential of blended OA as alternatives to BAC to protect broilers from NE indicated by improved FCR, immunity, digestibility, and bird welfare.  相似文献