SIPI Expansion     

McGowan A 《Science (New York, N.Y.)》1976,192(4240):614

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Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22     

Adams EJ  Chien YH  Garcia KC 《Science (New York, N.Y.)》2005,308(5719):227-231

Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is lacking for gammadelta TCRs. We present the 3.4 A structure of the murine gammadelta TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly uses germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in alphabeta TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies.  相似文献   

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP   总被引：2，自引：0，他引：2  

Lewis J  Dickson DW  Lin WL  Chisholm L  Corral A  Jones G  Yen SH  Sahara N  Skipper L  Yager D  Eckman C  Hardy J  Hutton M  McGowan E 《Science (New York, N.Y.)》2001,293(5534):1487-1491

JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice expressing mutant beta-amyloid precursor protein (APP), thus modulating the APP-Abeta (beta-amyloid peptide) environment. The resulting double mutant (tau/APP) progeny and the Tg2576 parental strain developed Abeta deposits at the same age; however, relative to JNPL3 mice, the double mutants exhibited neurofibrillary tangle pathology that was substantially enhanced in the limbic system and olfactory cortex. These results indicate that either APP or Abeta influences the formation of neurofibrillary tangles. The interaction between Abeta and tau pathologies in these mice supports the hypothesis that a similar interaction occurs in Alzheimer's disease.  相似文献   

Some three-body atomic systemn     

McGowan JW 《Science (New York, N.Y.)》1970,167(3921):1083-1092

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Regulation of chromatin remodeling by inositol polyphosphates     

Steger DJ  Haswell ES  Miller AL  Wente SR  O'Shea EK 《Science (New York, N.Y.)》2003,299(5603):114-116

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Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk     

Abtahian F  Guerriero A  Sebzda E  Lu MM  Zhou R  Mocsai A  Myers EE  Huang B  Jackson DG  Ferrari VA  Tybulewicz V  Lowell CA  Lepore JJ  Koretzky GA  Kahn ML 《Science (New York, N.Y.)》2003,299(5604):247-251

Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expression of slp-76 could not be detected in endothelial cells, and blood-filled lymphatics also arose in wild-type mice reconstituted with SLP-76-deficient bone marrow. These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals.  相似文献   

Evolution of block copolymer lithography to highly ordered square arrays     

Tang C  Lennon EM  Fredrickson GH  Kramer EJ  Hawker CJ 《Science (New York, N.Y.)》2008,322(5900):429-432

The manufacture of smaller, faster, more efficient microelectronic components is a major scientific and technological challenge, driven in part by a constant need for smaller lithographically defined features and patterns. Traditional self-assembling approaches based on block copolymer lithography spontaneously yield nanometer-sized hexagonal structures, but these features are not consistent with the industry-standard rectilinear coordinate system. We present a modular and hierarchical self-assembly strategy, combining supramolecular assembly of hydrogen-bonding units with controlled phase separation of diblock copolymers, for the generation of nanoscale square patterns. These square arrays will enable simplified addressability and circuit interconnection in integrated circuit manufacturing and nanotechnology.  相似文献   

Metal chelation and inhibition of bacterial growth in tissue abscesses     

Corbin BD  Seeley EH  Raab A  Feldmann J  Miller MR  Torres VJ  Anderson KL  Dattilo BM  Dunman PM  Gerads R  Caprioli RM  Nacken W  Chazin WJ  Skaar EP 《Science (New York, N.Y.)》2008,319(5865):962-965

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A critical role for eosinophils in allergic airways remodeling     

Humbles AA  Lloyd CM  McMillan SJ  Friend DS  Xanthou G  McKenna EE  Ghiran S  Gerard NP  Yu C  Orkin SH  Gerard C 《Science (New York, N.Y.)》2004,305(5691):1776-1779

Features of chronic asthma include airway hyperresponsiveness, inflammatory infiltrates, and structural changes in the airways, termed remodeling. The contribution of eosinophils, cells associated with asthma and allergy, remains to be established. We show that in mice with a total ablation of the eosinophil lineage, increases in airway hyperresponsiveness and mucus secretion were similar to those observed in wild-type mice, but eosinophil-deficient mice were significantly protected from peribronchiolar collagen deposition and increases in airway smooth muscle. These data suggest that eosinophils contribute substantially to airway remodeling but are not obligatory for allergen-induced lung dysfunction, and support an important role for eosinophil-targeted therapies in chronic asthma.  相似文献   

A retrotransposon-mediated gene duplication underlies morphological variation of tomato fruit     

Xiao H  Jiang N  Schaffner E  Stockinger EJ  van der Knaap E 《Science (New York, N.Y.)》2008,319(5869):1527-1530

Edible fruits, such as that of the tomato plant and other vegetable crops, are markedly diverse in shape and size. SUN, one of the major genes controlling the elongated fruit shape of tomato, was positionally cloned and found to encode a member of the IQ67 domain-containing family. We show that the locus arose as a result of an unusual 24.7-kilobase gene duplication event mediated by the long terminal repeat retrotransposon Rider. This event resulted in a new genomic context that increased SUN expression relative to that of the ancestral copy, culminating in an elongated fruit shape. Our discovery demonstrates that retrotransposons may be a major driving force in genome evolution and gene duplication, resulting in phenotypic change in plants.  相似文献