Retrospective evaluation of COX‐2 expression,histological and clinical factors as prognostic indicators in dogs with renal cell carcinomas undergoing nephrectomy          下载免费PDF全文

S. Carvalho  A. L. Stoll  S. L. Priestnall  A. Suarez‐Bonnet  K. Rassnick  S. Lynch  I. Schoepper  G. Romanelli  P. Buracco  M. Atherton  E. M. de Merlo  A. Lara‐Garcia 《Veterinary and comparative oncology》2017,15(4):1280-1294

Limited veterinary literature is available regarding prognostic markers for canine renal cell carcinoma (CRCC). We retrospectively evaluated COX‐2 expression, histological and clinical features associated with prognosis of CRCC. Sixty‐four cases post‐nephrectomy were included, 54 had histopathological assessment and 30 had COX‐2 immunostaining performed. Eight dogs (13%) had metastatic disease at initial diagnosis. Twenty‐seven dogs (42%) received adjuvant therapy after nephrectomy. On univariate analysis, COX‐2 expression, mitotic index (MI), histologic type, vascular invasion, neoplastic invasiveness and metastasis at diagnosis were significantly associated with overall median survival time (MST). COX‐2 score (COX‐2 score > 3 MST 420 days versus 1176 days if COX‐2 score <3; P = 0.011) and MI (MI > 30 MST 120 days versus 540 days for MI < 30; P = 0.003) were the only variables associated with CRCC outcome on multivariate analysis. The addition of MI and COX‐2 immunostaining to standard histopathological evaluation would help predicting outcome in CRCC patients.  相似文献   

A case of presumed autoimmune subepidermal blistering dermatosis treated with oclacitinib          下载免费PDF全文

Estelle Aymeric  Emmanuel Bensignor 《Veterinary dermatology》2017,28(5):512-e123

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Native egg parasitoids recorded from the invasive <Emphasis Type="Italic">Halyomorpha halys</Emphasis> successfully exploit volatiles emitted by the plant–herbivore complex     

Gabriele Rondoni  Valeria Bertoldi  Robert Malek  Maria Cristina Foti  Ezio Peri  Lara Maistrello  Tim Haye  Eric Conti 《Journal of pest science》2017,90(4):1087-1095

When an accidentally introduced pest establishes in the invaded area, native natural enemies may adapt to the new host. A decade after the accidental introduction of the brown marmorated stink bug, Halyomorpha halys, in Europe, two generalist native egg parasitoids, the eupelmid Anastatus bifasciatus and the encyrtid Ooencyrtus telenomicida, have been recorded from this invasive agricultural pest in the field. Both species are able to complete development to the adult stage within the new host. Trissolcus basalis (Platygastridae = Scelionidae), which is not associated with H. halys in the field, was reared from freeze-killed sentinel eggs placed on soybean plants in central Italy. We tested in a Y-tube olfactometer the behavioural responses of these egg parasitoids to volatiles from H. halys adults and from Vicia faba plants attacked by H. halys. Both A. bifasciatus and O. telenomicida positively responded to adult H. halys male volatiles and to H. halys-induced plant volatiles, indicating ability to exploit cues associated with the new host for egg location, whereas T. basalis only reacted to female volatiles. A. bifasciatus and O. telenomicida are generalist egg parasitoids, showing a much wider host range when compared to T. basalis. On the other hand, platygastrid egg parasitoids from the native area of H. halys, considered for classical biological control, may be too risky due to the possibility of attacking non-target species, including predaceous stink bugs. Therefore, indigenous A. bifasciatus and O. telenomicida are presently under evaluation for augmentative biological control of H. halys in Europe.  相似文献   

The intrinsic toxicity of several neonicotinoids to Lygus lineolaris and Hyaliodes vitripennis, a phytophagous and a predacious mirid     

Bostanian NJ  Hardman JM  Ventard E  Racette G 《Pest management science》2005,61(10):991-996

The tarnished plant bug Lygus lineolaris (Palisot de Beauvois) is a key pest of apples in eastern Canada and, currently, chemical control is the only way to manage this pest. Hyaliodes vitripennis (Say) is a univoltine indigenous predacious mirid and an integral part of biological control programs for apples in certain regions of Quebec. In worst-case laboratory conditions, thiamethoxam, thiacloprid and acetamiprid were exceptionally toxic to this predacious mirid. The adults were more susceptible than the nymphs. However, the residual toxicity of these neonicotinoids to L lineolaris in orchards was very short-lived. Because of the short residual toxicity, neonicotinoids should be applied when L lineolaris is at maximum abundance and well before eggs of H vitripennis hatch in late June.  相似文献   

Influence of obesity on plasma lipid and lipoprotein concentrations in dogs   总被引：3，自引：0，他引：3  

Jeusette IC  Lhoest ET  Istasse LP  Diez MO 《American journal of veterinary research》2005,66(1):81-86

OBJECTIVE: To determine effects of obesity and diet in dogs on plasma lipid and lipoprotein concentrations by assaying plasma leptin and ghrelin concentrations and determining total plasma cholesterol and triglyceride concentrations as well as the concentrations of cholesterol and triglycerides in various lipoprotein classes (ie, very-low-density, low-density, and high-density lipoproteins). ANIMALS: 24 Beagles; 12 lean (mean [+/- SEM] body weight, 12.7 +/- 0.7 kg) and 12 chronically obese (21.9 +/- 0.8 kg) dogs of both sexes, between 1 and 9 years old. PROCEDURES: Total plasma cholesterol and triglyceride concentrations; lipoprotein cholesterol and triglyceride concentrations; and plasma ghrelin, leptin, free fatty acids, insulin, and glucose concentrations were measured and compared between lean and obese dogs, both of which were fed a complete and balanced maintenance diet. Chronically obese dogs were subsequently fed a high-protein low-energy diet to evaluate effects of diet composition on plasma lipid and lipoprotein measurements. RESULTS: Chronic obesity resulted in a significant decrease in plasma ghrelin concentration and a significant increase in plasma leptin, cholesterol, and triglyceride concentrations in dogs. High total plasma cholesterol and triglyceride concentrations resulted from increased cholesterol and triglyceride concentrations in all lipoprotein fractions. In obese dogs, modification of diet composition resulted in beneficial effects on plasma lipid and leptin concentrations, even before weight loss was observed. CONCLUSIONS AND CLINICAL RELEVANCE: Correlations exist between obesity and plasma measurements (ie, lipoproteins, leptin, insulin, and ghrelin) commonly associated with obesity. Modification of diet composition to control energy intake improves plasma lipid and leptin concentrations in obese dogs.  相似文献   

African swine fever and classical swine fever: a review of the pathogenesis     

Gómez-Villamandos JC  Carrasco L  Bautista MJ  Sierra MA  Quezada M  Hervas J  Chacón Mde L  Ruiz-Villamor E  Salguero FJ  Sónchez-Cordón PJ  Romanini S  Núñez A  Mekonen T  Méndez A  Jover A 《DTW. Deutsche tier?rztliche Wochenschrift》2003,110(4):165-169

This paper describes major pathogenetic mechanisms of African and Classical Swine Fever virus infections. The interactions between both viruses and the monocyte-macrophage-system result in the release of mediator molecules, which are important for the further progression of the diseases. The causes of the thrombocytopenia and the mechanisms of the haemorrhages, which are characteristic in both infections, are described. Apoptotic cell death is regarded as the predominant cause of lymphopenia in both virus infections.  相似文献   

Pharmacokinetics and anesthetic and cardiopulmonary effects of propofol in red-tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus)     

Hawkins MG  Wright BD  Pascoe PJ  Kass PH  Maxwell LK  Tell LA 《American journal of veterinary research》2003,64(6):677-683

OBJECTIVE: To determine induction doses, anesthetic constant rate infusions (CRI), and cardiopulmonary effects of propofol in red-tailed hawks and great horned owls and propofol pharmacokinetics in the owls during CRI. ANIMALS: 6 red-tailed hawks and 6 great horned owls. PROCEDURE: The CRI dose necessary for a loss of withdrawal reflex was determined via specific stimuli. Anesthesia was induced by IV administration of propofol (1 mg/kg/min) and maintained by CRI at the predetermined dose for 30 minutes. Heart and respiratory rates, arterial blood pressures, and blood gas tensions were obtained in awake birds and at various times after induction. End-tidal CO2 (ETCO2) concentration and esophageal temperature were obtained after induction. Propofol plasma concentrations were obtained after induction and after completion of the CRI in the owls. Recovery times were recorded. RESULTS: Mean +/- SD doses for induction and CRI were 4.48 +/- 1.09 mg/kg and 0.48 +/- 0.06 mg/kg/min, respectively, for hawks and 3.36 +/- 0.71 mg/kg and 0.56 +/- 0.15 mg/kg/min, respectively, for owls. Significant increases in PaCO2, HCO3, and ETCO2 in hawks and owls and significant decreases in arterial pH in hawks were detected. A 2-compartment model best described the owl pharmacodynamic data. Recovery times after infusion were prolonged and varied widely. Central nervous system excitatory signs were observed during recovery. CONCLUSIONS AND CLINICAL RELEVANCE: Effects on blood pressure were minimal, but effective ventilation was reduced, suggesting the need for careful monitoring during anesthesia. Prolonged recovery periods with moderate-to-severe excitatory CNS signs may occur in these species at these doses.  相似文献   

Genetic variability of clutch length in dwarf layers: prospects for poultry breeding     

Tixier-Boichard M  Chen CF  Schobert A  Heirman T  Garcia Lara T 《British poultry science》2003,44(5):798-800

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Terbutaline pharmacokinetics in cows: preliminary data          下载免费PDF全文

Melanie J. Boileau  Kevin E. Washburn  Cyril R. Clarke  Robert N. Streeter    Lara K. Maxwell 《Canadian journal of veterinary research》2007,71(1):70-73

The objective of this study was to determine the serum pharmacokinetics of terbutaline in healthy cows. In the initial experiment, terbutaline was administered once as an intravenous (i.v.) bolus to 6 near-term pregnant beef cows within 24 h after parturition at a low but therapeutically relevant dose, 5 microg/kg. A 2nd experiment was conducted in the same cows with a higher dose, 0.5 mg/kg, but an otherwise similar experimental design. The serum concentration of terbutaline was determined by means of high-performance liquid chromatography with fluorescence detection in both experiments. After i.v. administration of 0.5 mg/kg, the mean peak serum concentration, residence time, and half-life were 708.22 (standard deviation 509.6) ng/mL, 6.75 (3.6) min, and 6.93 (2.4) min, respectively. The results indicate that terbutaline is rapidly eliminated from the bloodstream after i.v. administration in cattle, falling below the assay's limit of detection 30 min after administration.  相似文献   

Response of collembolan assemblages to plant species successional gradient     

Gabriel Perez  Thibaud Decaëns  Gaylord Dujardin  Marthe Akpa-Vinceslas  Estelle Langlois  Matthieu Chauvat 《Pedobiologia》2013,56(4-6):169-177

It has been acknowledged that soil organisms play a significant role in nutrient cycling and thus may affect productivity and competition within plant assemblages with potential effects on vegetation trajectories. However, few studies have considered a single conceptual framework referring to both above–belowground linkages and plant succession. Consequently, we lack knowledge on the effects of plant successional processes on the dynamics of soil biota. Given this dearth of information, our study aimed to describe the dynamics of a major group of soil fauna, namely collembola, during the secondary succession on chalky slopes edging the Seine River. We selected five different plant assemblages as representative of a chronosequence: short grassland, tall grassland, encroached grassland, shrubland and forest. Our results clearly highlighted a strong response of collembolan assemblages to vegetation gradient. The changes in collembolan diversity were due to a high turnover rate in early successional stages and to nestedness in late successional stages. In addition, each collembolan life form had a specific response to vegetal succession. Euedaphic assemblages increased progressively during the succession while epedaphic did not follow a clear pattern. Our results also indicated a link between the dynamics of collembolan assemblages and plant life forms (e.g. trees and graminoids) rather than plant diversity. A focus on life forms, for plants and soil biota, seems to provide a good framework to study linkages between above and belowground biota.  相似文献