Surgical management of adrenal gland tumors with and without associated tumor thrombi in dogs: 40 cases (1994-2001)     

Kyles AE  Feldman EC  De Cock HE  Kass PH  Mathews KG  Hardie EM  Nelson RW  Ilkiw JE  Gregory CR 《Journal of the American Veterinary Medical Association》2003,223(5):654-662

OBJECTIVE: To compare pathologic findings and results of adrenalectomy for adrenal gland tumors in dogs with and without vena caval tumor thrombi. DESIGN: Retrospective study. ANIMALS: 40 dogs with adrenal gland tumors. PROCEDURE: Medical records were examined. An exact logistic regression analysis was used to evaluate associations between tumor type or right-sided versus left-sided tumor involvement and development of caval tumor thrombi and associations between tumor thrombi, tumor type, or right- versus left-sided location and perioperative complications and mortality rate. Survival was compared between dogs with and without tumor thrombi. RESULTS: Caval thrombi were detected in 25% of dogs, including 3 of 28 (11%) dogs with an adrenocortical tumor and 6 of 11 dogs with a pheochromocytoma. A caval tumor thrombus was detected in 6 of 17 right-sided and 4 of 20 left-sided tumors. Sensitivity and specificity of abdominal ultrasonography for detection of caval thrombi were 80 and 90%, respectively. Intraoperative and postoperative complications developed in 15 and 51% of dogs, respectively. The mortality rate was 22%. There were no significant differences in perioperative morbidity and mortality rates between dogs with and without tumor thrombi. CONCLUSIONS AND CLINICAL RELEVANCE: Caval thrombi associated with adrenal gland tumors are amenable to adrenalectomy and thrombectomy without significantly increased perioperative morbidity and mortality rates, assuming the surgeon is experienced in appropriate techniques.  相似文献   

Tularemia     

Feldman KA 《Journal of the American Veterinary Medical Association》2003,222(6):725-730

Tularemia is a rare but potentially fatal disease that develops in numerous wild and domestic animals, including lagomorphs, rodents, cats, and humans. The disease occurs throughout much of the United States and should be considered in the differential diagnosis of acute febrile illness, particularly when risk factors such as contact with wild mammals or tick exposure are present. Veterinarians may be at increased risk of acquiring tularemia from contact with infected animals, but standard precautions should greatly reduce this risk. Outbreaks of tularemia warrant investigation, especially given the possibility of the use of F tularensis as an agent of bioterrorism.  相似文献   

Percutaneous ultrasound-guided radiofrequency heat ablation for treatment of hyperthyroidism in cats     

Mallery KF  Pollard RE  Nelson RW  Hornof WJ  Feldman EC 《Journal of the American Veterinary Medical Association》2003,223(11):1602-1607

OBJECTIVE: To determine efficacy and safety of percutaneous radiofrequency heat ablation for treatment of hyperthyroidism in cats. DESIGN: Prospective study. ANIMALS: 9 cats. PROCEDURE: Hyperthyroidism was diagnosed via clinical signs and high serum total (TT4) and free thyroxine (fT4) concentrations. One or 2 hyperfunctional cervical thyroid nodules were detected by use of scintigraphy and ultrasonography. If cats had 1 abnormal thyroid lobe, heat ablation was performed on that lobe; if cats had 2 abnormal lobes, heat ablation was applied to the larger lobe. Overall, heat ablation was performed 14 times in the 9 cats. Clinical signs and serum TT4, fT4, and calcium concentrations were monitored daily for 2 days after the procedure, weekly for the first month, and then monthly. Laryngeal function was evaluated and cervical ultrasonography and thyroid scintigraphy were also performed. Monitoring continued for as long as 9 months after heat ablation if a cat became euthyroid or until an owner chose an alternative treatment because of recurrence of hyperthyroidism. RESULTS: Serum TT4 and fT4 concentrations transiently decreased after all 14 heat ablation procedures (< or = reference range after 10 of 14 treatments) within 2 days after the procedure. Cats were euthyroid for 0 to 18 months (mean, 4 months). Hyperthyroidism recurred in all cats. Adverse effects included transient Horner's syndrome (2 cats) and laryngeal paralysis without clinical signs (1 cat). CONCLUSIONS AND CLINICAL RELEVANCE: Percutaneous heat ablation as a treatment for hyperthyroidism in cats is effective transiently but not permanently.  相似文献   

Factor X deficiency in a Jack Russell terrier     

Cook AK  Werner LL  O'Neill SL  Brooks M  Feldman BF 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1993,22(3):68-71

Deficiency in factor X (Stuart-Prower factor) was identified in a 7-month-old spayed female Jack Russell Terrier following recurrent bleeding episodes. Various relatives were screened for factor X deficiency and low and subnormal levels were identified in the father and paternal grandmother, respectively. Factor X deficiency has been previously documented in a family of American Cocker Spaniels, in which the inheritance pattern appeared to be an autosomal dominant trait with variable expression. This is the first report describing this coagulopathy in the Jack Russell Terrier.  相似文献   

Cytologic, microbiologic, and biochemical analysis of bronchoalveolar lavage fluid obtained from 24 healthy cats   总被引：3，自引：0，他引：3  

P A Padrid  B F Feldman  K Funk  E M Samitz  D Reil  C E Cross 《American journal of veterinary research》1991,52(8):1300-1307

Twenty-four healthy cats underwent bronchoscopy and bronchoalveolar lavage to determine the normal cytologic environment of the lower respiratory tract of cats. Initial screening to ensure the health of the study population included complete histories, physical examinations, thoracic radiography, CBC, serologic tests for feline leukemia virus, feline immunodeficiency virus, and occult heartworm, and sugar and Baermann fecal flotation. In 18 cats, protected catheter brush samples of airway secretions from the lavaged lung segment were taken for culture of aerobic and anaerobic bacteria and mycoplasma. Bronchial lavage fluid (5 sequential 10-ml aliquots of normal saline solution) was pooled and filtered with cotton gauze. The unspun sample was used for determination of a total nucleated cell count. Lavage fluid was cytocentrifuged and 500 cells/slide were scored for determination of the cellular differential. Activity of lactate dehydrogenase and concentrations of total protein and IgG within the supernatant were measured, and assays were performed to detect the presence of IgA and IgM. Complete histologic evaluation of the lavaged lung of each of 6 random-source cats was performed after differential cell counting revealed 18% eosinophils within bronchoalveolar lavage fluid recovered from this group. Alveolar macrophages were the predominant cells encountered; however, a quarter of all cells recovered were eosinophils. A significant relationship was not found between the abundance of eosinophils in the lavage fluid, and either isolation of aerobic bacteria, high total nucleated cell counts, total protein concentrations, or activity of lactate dehydrogenase. Histologic evaluation of the lungs of 5 of 6 random-source cats revealed normal lungs in 2 cats, and minimal abnormal change in 3 others. Evaluation of the lungs from 1 random source cat revealed acute, mild eosinophilic bronchiolitis. We conclude that large numbers of eosinophils may be retrieved from the bronchoalveolar lavage fluid of healthy cats.  相似文献   

Central diabetes insipidus in a dog.     

E C Feldman 《Modern veterinary practice》1979,60(8):615-619

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Congenital diaphragmatic hernia in neonatal dogs     

D B Feldman  M M Bree  B J Cohen 《Journal of the American Veterinary Medical Association》1968,153(7):942-944

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Hypoadrenocorticism in a dog.     

E C Feldman  S J Ettinger 《Modern veterinary practice》1977,58(5):433-438

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Clinical toxicities of pet and caged rodents and rabbits.     

S M Kruckenberg  J E Cook  B F Feldman 《The Veterinary clinics of North America》1975,5(4):675-684

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The anemia of inflammatory disease in the dog I. The nature of the problem     

B. F. Feldman  J. J. Kaneko 《Veterinary research communications》1980,4(1):237-252

The anemia of inflammatory disease (AID) in the dog is an almost invariable complication of infection, inflammation and disseminated or necrotizing neoplastic disease. Clinically innocuous, it is important only in the greater under-standing of the mechanisms controlling circulating erythrocyte quantity and quality. The etiology and pathogenesis include a shortened red cell life-span, disordered iron metabolism, depressed bone marrow response to the anemia and a disordered iron storage. The laboratory features of a moderate anemia, normal bone marrow cellular pattern, depression in iron metabolism and reticuloendothelial iron sequestration make a final diagnosis of AID dependent on ruling out other etiologic mechanisms which may obscure or aggravate the anemia of inflammatory disease in the dog.

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Kurzfassung Die Anämie der entzündlichen Erkrankung des Hundes ist eine komplizierende Begleiterscheinung von Infektionen, Entzündungen und disseminierten oder neoplastischen Erkrankungen. Klinisch unbedeutend ist diese Anämie nur im Sinne eines weiteren Verständnisses der Mechanismen bedeutsam, die Zahl und Menge der zirkulierenden Erythrozyten kontrollieren. Atiologie und Pathogenese umfassen eine verkürzte Lebensdauer der Erythrozyten, Störungen im Eisenstoffwechsel, unterdrückte Knochenmarksreaktion auf die Anämie und eine gestörte Eisenspeicherung. Laborwerte wie moderate Anämie, normale Knochenmarkszellbilder, unterdrückter Eisenstoffwechsel und RES-Eisen-Absonderung sprechen für die Diagnose einer Anämie der entzündlichen Erkrankung, vorausgesetzt, dass andere ätiologische Ursachen, die eine Anämie verschleiern oder erschweren können, ausgeschlossen werden.

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