Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists   总被引：87，自引：0，他引：87  

T Honoré  S N Davies  J Drejer  E J Fletcher  P Jacobsen  D Lodge  F E Nielsen 《Science (New York, N.Y.)》1988,241(4866):701-703

The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.  相似文献   

Dependence of stem cell fate in Arabidopsis on a feedback loop regulated by CLV3 activity   总被引：2，自引：0，他引：2  

Brand U  Fletcher JC  Hobe M  Meyerowitz EM  Simon R 《Science (New York, N.Y.)》2000,289(5479):617-619

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Freezing equine semen: the effect of combinations of semen extenders and glycerol on post-thaw motility   总被引：1，自引：1，他引：0  

J Scherzer  RA Fayrer-Hosken  M Aceves  DJ Hurley  LE Ray  L Jones  GL Heusner 《Australian veterinary journal》2009,87(7):275-279

Objective   We evaluated combinations of two commercial semen extenders and three concentrations of glycerol to determine the combination that yielded the highest post-thaw sperm motility.
Design   A randomised 2 × 3 block design was used.
Procedure   Semen was collected from four stallions (6 collections per stallion). The sample was diluted with either a dried skim-milk glucose extender (EZ Mixin Original Formula) or a chemically defined, milk-free diluent (INRA 96), and each was used in combination with 2%, 3% or 4% glycerol in standard commercial freezing medium. Sperm motility was assessed by microscopy in fresh and post-thaw semen.
Results   There was a significant difference between the two extenders in the motility of spermatozoa after cryopreservation (48.9% for INRA 96; 38.6% for EZ Mixin OF; P < 0.0001). Glycerol at 4% in freezing medium yielded the highest post-thaw motility, significantly better than 2% ( P < 0.05). Three of four stallions had significantly higher post-thaw motility using INRA 96 relative to EZ Mixin OF ( P < 0.01), and two of four stallions had significantly higher post-thaw motility using 4% glycerol ( P < 0.05). The combination of INRA 96 and 4% glycerol in freezing medium gave the highest average post-thaw motility of 51.5%.
Conclusion   In this study, INRA 96 combined with 4% glycerol yielded an average recovery of progressively motile sperm consistently above the 35% target.  相似文献   

Porcine β1,4-Galactosyltransferase-I Sequence and Expression     

EA Landers  HR Burkin  GT Bleck  L Howell-Skalla  DJ Miller 《Reproduction in domestic animals》2009,44(2):228-234

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棉籽粕补饲对新疆细毛羊氮代谢的影响     

邓凯东  I. C. Fletcher  J. V. Nolan 《西北农业学报》1999,8(1):23-26

将２４只约１５月龄的新疆细毛母羊（平均体重２８．９ｋｇ）随机分为６个处理组（每处理４只）,以基础日粮作对照,混合精料日粮作标准,研究不同水平棉籽粕补饲的效果。结果表明,棉籽粕补饲显著提高了（Ｐ〈０．０５）绵羊的总氮采食量、氮表现消化率、氮沉积、尿囊素排出量和由尿囊素排出量估测的瘤胃微生物氮产量。补饲棉籽粕绵羊的瘤胃微生物氮产量显著低于（Ｐ〈０．０５）饲喂混合精料的绵羊,这可能与前者的能量采食量较低  相似文献