Cancer detection in clinical practice and using blood-based liquid biopsy: A retrospective audit of over 350 dogs     

Andi Flory  Lisa McLennan  Betsy Peet  Marissa Kroll  Deirdre Stuart  Devon Brown  Kathy Stuebner  Brenda Phillips  Brenda L. Coomber  J. Paul Woods  Mairin Miller  Chelsea D. Tripp  Amber Wolf-Ringwall  Kristina M. Kruglyak  Angela L. McCleary-Wheeler  Ashley Phelps-Dunn  Lilian K. Wong  Chelsea D. Warren  Gina Brandstetter  Michelle C. Rosentel  Lauren R. DiMarzio  Allison L. O'Kell  Todd A. Cohen  Daniel S. Grosu  Jason Chibuk  Dana W. Y. Tsui  Ilya Chorny  Jill M. Rafalko 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(1):258-267

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Effects of roads and forest successional age on experimental plant invasions     

S. Luke Flory  Keith Clay 《Biological conservation》2009,142(11):2531-2537

Anthropogenic activities can promote plant invasions by changing habitat conditions and the dispersal of invasive plant propagules. Invasions are often more common near roads and in young habitats than in interior and mature habitats, but it is unknown if these patterns are due to differences in habitat conditions or to dispersal limitation. We tested if reduced colonization of interior and mature forests by invasive plants is due to unfavorable habitat conditions. We experimentally introduced seeds and seedlings of three invasive and three native species at six distances from roads in a series of young and mature forests. Seed germination and seedling survival, growth, and herbivore damage were quantified over three years. Exotics had higher germination rates than natives with the greatest difference in mature forests. Both native and exotic seedling growth declined with increasing distance from roads. Overall, seedling growth was much greater in young compared to mature forests. Despite growth rate differences, more than 75% of exotic and native seedlings survived over the experiment. Native species suffered significantly more herbivory than exotic species, suggesting that their growth may be suppressed by herbivory. In general, conditions along roads and in young forests promoted invasive shrub growth but invasions were not entirely limited by conditions in interior and mature forests. Our results show that two common landscape features, roads, and successional age heterogeneity, can influence the distribution of plant invasions. To better manage these invasive species, mature forests should be maintained and disturbances such as road–building should be avoided.  相似文献   

Transient phase-induced nucleation     

EB Sirota  AB Herhold 《Science (New York, N.Y.)》1999,283(5401):529-532

A transient metastable rotator phase occurring on crystallization of hexadecane into its triclinic phase from the supercooled melt was directly observed with time-resolved synchrotron x-ray scattering. In this system, the limit of supercooling (the crystallization temperature) is determined by the thermodynamic stability of the transient phase with respect to the liquid. The crystallization kinetics of the homologous series of n-alkanes was measured and explained in terms of a crossover from stability to "long-lived" metastability to transient metastability. This crossover allowed further confirmation of the nature of the transient phase.  相似文献   

Role of Crystallization in Polymers and Proteins     

Flory PJ 《Science (New York, N.Y.)》1956,124(3211):53-60

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Spatial configuration of macromolecular chains     

Flory PJ 《Science (New York, N.Y.)》1975,188(4195):1268-1276

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3-Methylindole-induced nasal mucosal damage in mice   总被引：1，自引：0，他引：1  

M A Turk  W G Henk  W Flory 《Veterinary pathology》1987,24(5):400-403

3-Methylindole (3MI) damages nasal olfactory epithelium in mice. Lesions were studied histologically from 30 minutes to 28 days after intraperitoneal injection of 400 mg 3MI/kg. Cellular swelling was apparent in olfactory epithelium by 6 hours after injection of 3MI, while respiratory epithelium was normal. Necrosis of olfactory epithelium and subepithelial glands was diffuse by 48 hours. Subsequent ulceration resulted in epithelial hyperplasia, squamous metaplasia, fibroplasia, and ossification. Partially occlusive intranasal fibrous and osseous tissue persisted through 28 days after 3MI injection.  相似文献   

ACQUIRED MEGAESOPHAGUS IN A HEIFER     

Uri  Bargai  AB  VMD  DVSc.  Ami Tsvi  Nathan  DVM  Shmuel  Pearl  DVM 《Veterinary radiology & ultrasound》1991,32(5):259-260

An 18-month-old pregnant heifer, hitherto normal, was noticed to regurgitate wet, partially digested roughage several times a day. On clinical examination, the heifer was losing body weight. There was no obstacle to passing a stomach tube to the rumen. A barium study of the esophagus was performed. Megaesophagus involving the cervical and cranial thoracic esophagus was diagnosed. Postmortem findings were a dilated esophagus, with no gross pathology seen. Histopathology showed extensive submucosal cellular infiltration of eosinophils. The classification and possible etilogy of the case is discussed.  相似文献   

Smooth muscle inhibition by an extract of Sesbania drummondii     

C S Venugopalan  N A O'Malley  M L Marceau-Day  W Flory 《American journal of veterinary research》1987,48(2):293-296

The acute effects of an extract of Sesbania drummondii were assessed in vitro on the smooth muscle contractility of intestine and lung parenchyma in the chicken and aortic arch in the rat. Dose-response contraction curves for histamine, carbachol, and norepinephrine were obtained in the ileal, parenchymal, and aortic strips, respectively. After washing was completed, the strips returned to baseline tensions and then were incubated for 10 minutes with an ethyl acetate extraction fraction of S drummondii (molecular weight less than 500). Dose-response curves to the same agonists were repeated at the end of the incubation period. Contractile responsiveness of chicken ileum was little affected by acute incubation of the tissue with the extract. Comparison with the great inhibition of in vitro ileal contractility seen previously in chickens with chronic toxicosis indicated that intestinal inhibition was not due to acute effects of sesbania, but required time for a toxic metabolite to be formed or for damage to occur from affected vasculature. Contractile responsiveness of chicken lung parenchyma to histamine (10(-5) M and 10(-4) M) was significantly decreased, as was rat aortic responsiveness to norepinephrine (10(-7) M to 10(-4) M). Responses in parenchyma were not as greatly inhibited as those in tissue from animals with chronic toxicosis. Greatest inhibition of contractility was seen in the vascular strips, indicating that vascular inhibition has a role in pathologic changes. To test the vasculature inhibition effect in vivo, anesthetized, catheterized rats were given 100-microliter aliquots of dilutions of the extract, IV.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

Fertility Results after Vaginal Deposition of Frozen‐Thawed Buck Semen Diluted with Two Different Extenders Using One‐ or Two‐Step Procedures     

AB Nordstoga  L Söderquist  T Ådnøy  H Paulenz 《Reproduction in domestic animals》2011,46(1):82-86

In two field trials (T1 and T2), the effect of two different extenders for buck semen was tested. Semen from six (T1) and seven (T2) bucks of the Norwegian Dairy Goat breed was diluted either in a milk‐based extender containing egg yolk (M) or in a commercially available extender without egg yolk [Andromed^® (A)]. Dilution in M was performed in a two‐step procedure including centrifugation of the ejaculates and removal of the supernatant, while dilution in A was performed in one step. During the two trials (T1 and T2) 514 and 714, does, respectively, were artificially inseminated during natural oestrus, and the farmers performed the inseminations themselves after attending an artificial insemination (AI) training course. Vaginal insemination with 200 × 10⁶ spermatozoa diluted in M resulted in a 25‐day non‐return rate (NRR) and kidding rate of 37.3% and 24.5%, respectively, while semen diluted in A resulted in 31.7% NRR and a kidding rate of 19.8% (T1). In T2, NRR and kidding rate for AI performed with semen diluted with M were 42.7% and 28.5%, respectively, while dilution in A gave 37.2% NRR and a kidding rate of 26.8%. There was no significant effect of extender in the two trials [T1:p = 0.068 (NRR), p = 0.148 (kidding rate), T2:p = 0.096 (NRR), p = 0.38 (kidding rate)], but farmer had a significant effect on the fertility parameters in both trials. In conclusion, the present studies may indicate that Andromed^® is suitable for buck semen. However, more research is necessary to confirm the results and to improve the fertility of does after vaginal AI with frozen‐thawed semen.  相似文献   

U.s. Chemists withdraw from soviet symposium     

Mark HF  Stockmayer WH  Tschoegl NW  Flory PJ 《Science (New York, N.Y.)》1978,202(4364):126-127

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