FC‐7
Acral mutilation and analgesia due to hereditary sensory neuropathy in 13 French spaniels     

M. Paradis  C. De Jaham  N. Pag  F. Sauv  P. Hlie 《Veterinary dermatology》2004,15(Z1):22-22

The purpose of this study was to describe a new hereditary sensory neuropathy in French spaniels resulting in analgesia and progressive mutilation of the distal extremities. Thirteen French spaniels (six females, seven males) from five different litters with acral mutilation were identified. Clinical signs were first noted between 3.5 and 12 months of age and typically consisted of sudden excessive and intense licking and biting of toes and/or footpads of one or several feet. This generally progressed rapidly into swollen digits, paronychia, footpad ulceration, and occasionally fracture and osteomyelitis. If the affected dogs were unrestrained, auto‐amputation of claws, toes and footpads usually resulted. However, even in the more severe cases, affected dogs walked and ran on their mutilated feet without any evidence of lameness, pain or ataxia, and they allowed wound care without evidence of pain or discomfort. Dogs were otherwise healthy, with the exception of frequent secondary bacterial infections of the wounded feet. This disorder was clinically very difficult to manage, and the majority of the dogs were euthanized within days to months of diagnosis. None of the sires or dams of the affected dogs reported here were clinically affected. There was no apparent sex predilection. An autosomal recessive mode of inheritance was strongly suspected. The clinicopathological findings, the early age of onset and the disease progression in affected French spaniels were very similar to those reported for hereditary sensory neuropathy in German short‐haired pointers, English pointers and English springer spaniels. Funding: Self‐funded.  相似文献   

Serum-free thyroxine concentrations, measured by chemiluminescence assay before and after thyrotropin administration in healthy dogs, hypothyroid dogs, and euthyroid dogs with dermathopathies.          下载免费PDF全文

M Paradis  N Pag  N Larivire    M Fontaine 《The Canadian veterinary journal. La revue veterinaire canadienne》1996,37(5):289-294

The purpose of this study was to determine the usefulness of free thyroxine (FT4) measured by chemiluminescence in evaluating thyroid function in dogs. Total thyroxine (TT4) concentration measured by radioimmunoassay (RIA) and FT4 measured by chemiluminescence were evaluated in 30 healthy dogs, 60 euthyroid dogs with concurrent dermatopathies, and 30 hypothyroid dogs before and after intravenous stimulation with 1 or 2 IU of thyrotropin (TSH). Median basal TT4 and median TT4 concentrations at 4 h post-TSH administration were not significantly different (P < 0.0001) between healthy dogs and euthyroid dogs with dermatopathies, but were significantly higher than those in hypothyroid dogs. In healthy dogs, the median TT4 concentrations at 4 and 6 h post-TSH administration were not significantly different. Median basal FT4 and median FT4 concentrations at 4 h post-TSH administration in healthy dogs were significantly lower (P < 0.0001) than those in euthyroid dogs with dermatopathies, but significantly higher than the same parameters in hypothyroid dogs. There was a significant difference between the median FT4 concentrations at 4 h post-TSH administration and median basal FT4 concentrations for healthy dogs and euthyroid dogs with dermatopathies, but not for hypothyroid dogs. Lastly, in healthy dogs, median FT4 concentrations at 4 and 6 h post-TSH administration were not significantly different. Free thyroxine measured by chemiluminescence was highly correlated (P < 0.0001; Spearman r = 0.91) with FT4 measured by the reference method for free hormone analysis, namely, equilibrium dialysis, when sera from 56 dogs were used.  相似文献   

Effects of oral administration of tilmicosin on pulmonary inflammation in piglets experimentally infected with Actinobacillus pleuropneumoniae     

Nerland EM  LeBlanc JM  Fedwick JP  Morck DW  Merrill JK  Dick P  Paradis MA  Buret AG 《American journal of veterinary research》2005,66(1):100-107

OBJECTIVES: To determine the effects of oral administration of tilmicosin in piglets experimentally infected with Actinobacillus pleuropneumoniae. ANIMALS: Forty 3-week-old specific-pathogen free piglets. PROCEDURES: Piglets were assigned to 1 of 4 groups as follows: 1) uninfected sham-treated control piglets; 2) infected untreated piglets that were intratracheally inoculated with 10(7) CFUs of A pleuropneumoniae; 3) infected treated piglets that were intratracheally inoculated with A pleuropneumoniae and received tilmicosin in feed (400 ppm [microg/g]) for 7 days prior to inoculation; or 4) infected treated piglets that were intratracheally inoculated with A pleuropneumoniae and received chlortetracycline (CTC) in feed (1100 ppm [microg/gl) for 7 days prior to inoculation. Bronchoalveolar lavage (BAL) fluid and lung tissue specimens of piglets for each group were evaluated at 3 or 24 hours after inoculation. For each time point, 4 to 6 piglets/group were studied. RESULTS: Feeding of CTC and tilmicosin decreased bacterial load in lungs of infected piglets. Tilmicosin delivered in feed, but not CTC, enhanced apoptosis in porcine BAL fluid leukocytes. This was associated with a decrease in LTB4 concentrations in BAL fluid of tilmicosin-treated piglets, compared with untreated and CTC-treated piglets, and also with a significant decrease in the number of pulmonary lesions. Tilmicosin inhibited infection-induced increases in rectal temperatures, as measured in untreated and CTC-treated piglets. Pulmonary neutrophil infiltration and prostaglandin E2 concentrations in the BAL fluid were not significantly different among groups at any time. CONCLUSIONS AND CLINICAL RELEVANCE: Oral administration of tilmicosin to infected piglets induces apoptosis in BAL fluid leukocytes and decreases BAL fluid LTB4 concentrations and inflammatory lung lesions.  相似文献   

Planetary science. Alien weather at the poles of Mars     

Forget F 《Science (New York, N.Y.)》2004,306(5700):1298-1299

  相似文献   

Patterns of exotic plant invasions in fragmented urban and rural grasslands across continents     

Sarel S. Cilliers  Nicholas S. G. Williams  Francois J. Barnard 《Landscape Ecology》2008,23(10):1243-1256

Linear native grassland remnants in fragmented landscapes are usually at a great risk of exotic species invasion from their edges. Changes in species distribution near habitat edges are extensively studied in ecology as knowledge about edge responses is important to understand the development of patterns and processes in landscapes. However, elucidating robust general principles for edge effects has been difficult as species responses to habitat edges are highly variable and dependent on a large number of attributes which affect the function and structure of edges and therefore the distance that edge effects penetrate into fragmented natural vegetation. The objective of this study was to investigate the generality of exotic species invasion patterns from edges in native grassland patches surrounded by urban and rural landscapes. This was done by comparing the results of research from Victoria, Australia with a similar study from North-West Province, South Africa. Despite their occurrence on different continents, the grasslands are floristically and structurally similar and are dominated by the same grass species. Invasion patterns were quantified using two spatial statistics methods; block kriging and spatially constrained clustering. Two distinct patterns of exotic species invasion were identified in native grassland remnants in South Africa and Australia, namely exotic species invasion from the edge where the cover of exotic species increased with increasing proximity to the edge and a pattern that suggests that gap phase vegetation dynamics may also drive exotic species invasion at urban grasslands. Although urbanization and weed invasions are complex processes similar patterns of exotic species invasion in urban grasslands were found in two different continents suggesting that general patterns may occur. Implications of this for the conservation of native grasslands in contrasting landscapes are discussed.  相似文献   

Calcinosis cutis secondary to percutaneous penetration of calcium carbonate in a Dalmatian   总被引：1，自引：1，他引：0       下载免费PDF全文

Paradis M  Scott DW 《The Canadian veterinary journal. La revue veterinaire canadienne》1989,30(1):57-59

  相似文献   

欧洲现代木结构建筑不同的构造技术和成本分析     

施煜庭  王煜华  周定国 《林产工业》2011,38(1)

木材是一种可再生的、同时也是最古老的建筑材料之一。由于其天然美观的纹理、柔和的视觉效果、良好的保温隔热性能以及优良的力学性能,自上古时期的构木为巢开始就和人类生活息息相关,木结构建筑是人类最早兴建的建筑结构之一,积淀着丰厚的建筑文明传统。1欧洲现代木结构建筑发展概况建筑的发展史就是一部科学技术的发展史。技术手段的变革会超越风格流派等文化因素直接对建筑设计产生巨大的影响,并使得设计师的创作观念及设计方法也随之发生变化。这  相似文献   

The consequences of late outbreaks of the aphid Aphis gossypii in cotton growing in central Africa: Towards a possible method for the prevention of cotton stickiness     

Jean-Philippe Deguine  Eric Goze  Francois Leclant 《国际虫害防治杂志》2013,59(2):85-89

'Sticky cotton' causes substantial economic loss in central Africa. The phenomenon is the result of honeydew excreted by sapsucking insects, mainly the aphid Aphis gossypii Glover. The chemical protection currently available to farmers does not limit this type of damage effectively. From exhaustive counting of infested leaves and quantitative measurement of stickiness with a thermodetector, a positive relationship can be established between the seriousness of fibre stickiness and aphid outbreaks at the end of the season. A control method involving the topping of plants after boll opening reduces the number of leaves on which aphids feed and thus the abundance of the aphids.  相似文献   

Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number     

Flavell SW  Cowan CW  Kim TK  Greer PL  Lin Y  Paradis S  Griffith EC  Hu LS  Chen C  Greenberg ME 《Science (New York, N.Y.)》2006,311(5763):1008-1012

  相似文献   

Topical (pour-on) ivermectin in the treatment of canine scabies.          下载免费PDF全文

M Paradis  C de Jaham    N Pag 《The Canadian veterinary journal. La revue veterinaire canadienne》1997,38(6):379-382

The efficacy of a pour-on formulation of ivermectin at 500 micrograms/kg body weight applied on the dorsum on days 1 and 15 was evaluated in 90 dogs from a shelter, naturally infested with Sarcoptes scabiei. This very practical form of treatment was successful in eradicating scabies from this shelter.  相似文献