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51.
LoCascio RG Ninonuevo MR Freeman SL Sela DA Grimm R Lebrilla CB Mills DA German JB 《Journal of agricultural and food chemistry》2007,55(22):8914-8919
The molecular basis by which human breast milk supports the development of a protective intestinal microbiome in infants is unknown. After lactose and lipids, human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk. In this work, glycomic profiling of HMO consumption by bifidobacteria using Fourier transform ion cyclotron resonance mass spectrometry reveals that one species, Bifidobacterium longum biovar infantis ATCC 15697, an isolate from the infant gut, preferentially consumes small mass oligosaccharides, representing 63.9% of the total HMOs available. These HMOs were detected in human breast milk at the onset and constantly through the first month of lactation by use of high performance liquid chromatography-chip time-of-flight mass spectrometry. Further characterization revealed that strain ATCC 15697 possesses both fucosidase and sialidase activities not present in the other tested strains. This work provides evidence that these small mass HMOs are selectively metabolized by select bifidobacterial strains and represent a potential new class of bioactive molecules functioning as prebiotics to facilitate a protective gut colonization in breast-fed newborns. 相似文献
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A.C. Freeman S.R. Platt M. Kent E. Huguet C. Rusbridge S. Holmes 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(5):1551-1559
Background
Although Chiari‐like malformation (CM) and syringomyelia (SM) have been described in many small breed dogs, the prevalence and clinical manifestations of this complex have not been documented in a large cohort of American Brussels Griffon (ABG) dogs.Objectives
To characterize the clinical and magnetic resonance imaging (MRI) features of CM and SM in the ABG breed.Animals
Eighty‐four American Kennel Club registered ABG dogs were recruited.Methods
Prospective study. Complete histories and neurologic examinations were obtained before MRI. Images were blindly reviewed and calculations were made by using OsiriX. All analyses were performed by Student''s t‐test, Spearman''s correlation, ANOVA, and chi‐square test where appropriate.Results
Chiari‐like malformation and SM were present in 65% and 52% of dogs, respectively. Twenty‐eight percent of dogs had neurologic deficits and 20% had neck pain. Mean central canal (CC) transverse height was 2.5 mm with a mean length of 3.6 cervical vertebrae. Neurologic deficits were significantly associated with a larger syrinx (P = .04, P = .08) and syrinx size increased with age (P = .027). SM was associated with a smaller craniocervical junction (CCJ) height (P = .04) and larger ventricles (P = .0001; P < .001).Conclusions and Clinical Importance
Syringomyelia and CM are prevalent in American Brussels Griffon dogs. Syrinx size is associated with neurologic deficits, CM, larger ventricles, a smaller craniocervical junction height, neurologic deficits, and cerebellar herniation. Fifty‐two percent of dogs with a SM were clinically normal. 相似文献55.
L.M. Freeman J.E. Rush S.M. Cunningham B.J. Bulmer 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(3):847-856
Background
Diet might influence progression of hypertrophic cardiomyopathy (HCM).Objective
To investigate whether diet composition could alter clinical, biochemical, or echocardiographic variables in cats with HCM.Animals
Twenty‐nine cats with HCM (International Small Animal Cardiac Health Council stage 1b) examined at a university teaching hospital.Methods
Randomized, placebo‐controlled trial. After physical examination, echocardiogram, and blood collection, cats were randomized to 1 of 3 diets, which varied in carbohydrate and fat content and ingredients. Measurements were repeated after 6 months.Results
There were no significant differences among the 3 groups at baseline. After 6 months, there were no significant changes in the primary endpoints, left ventricular free wall (Group A, P = .760; Group B, P = .475; Group C, P = .066) or interventricular septal thickness in diastole (Group A, P = .528; Group B, P = .221; Group C, P = .097). Group A had significant increases in BUN (P = .008) and cholesterol (P = .021), while Group B had significant increases in BUN (P = .008), cholesterol (P = .007), and triglycerides (P = .005), and significant decreases in NT‐proBNP (P = .013) and hs‐troponin I (P = .043). Group C had significant decreases in body weight (P = .021), left atrial dimension (P = .035), interventricular septal thickness in systole (P = .038), and liver enzymes (P = .034–.038).Conclusions and Clinical Importance
These data suggest that diet might influence some clinical, biochemical, and echocardiographic variables in cats with HCM. 相似文献56.
57.
B. M. Freeman 《British poultry science》1985,26(2):141-145
The first issue of British Poultry Science was published in April 1960. In this paper the origin and development of the Journal and the organisations with which it has been associated are traced. 相似文献
58.
T S Ford D E Freeman M W Ross D W Richardson B B Martin J B Madison 《Journal of the American Veterinary Medical Association》1990,196(1):121-126
The case records of 26 horses with ileocecal intussusception over a 7-year period were reviewed to determine clinical features of the disease and response to treatment. The median age of horses with ileocecal intussusception was 1 year and ranged from 2 weeks to 19 years. There was no apparent gender or breed predisposition to this disease. An acute form of ileocecal intussusception was diagnosed in 19 horses with signs of moderate to severe abdominal pain of less than or equal to 24 hours' duration, and a chronic form was diagnosed in 7 horses with signs of intermittent, mild to moderate abdominal pain of more than 3 days' duration. Horses with chronic ileocecal intussusception had a history of weight loss or failure to gain weight, slow growth, poor appetite, low-grade pyrexia, and postprandial signs of abdominal pain. At surgery, the involved segments of intestine (intussusceptum and intussuscipiens) in chronic cases were 2 to 10 cm long, and the ileum and much of the distal portion of the jejunum were flaccid, dilated, and thick walled. In the acute cases, the length of involved intestine ranged from 6 to 457 cm. Whereas only 1 of 7 chronic intussusceptions (14%) could be reduced, 9 of 19 (47%) acute intussusceptions were reducible. Surgical treatment included resection and jejunocecostomy (6 horses), partial resection through a cecotomy and a side-to-side jejunocecostomy (2 horses), and a side-to-side ileocecostomy or jejunocecostomy without resection (12 horses, 7 of which had chronic intussusception). Six horses with acute intussusception were euthanatized before or during surgery.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
59.
60.
Development of cytoplasmic male sterile 《分子植物育种》2007,5(2):215-216
Development of cytoplasmic male sterile (CMS) lines with elongated uppermost internode (EUI) trait provides a genetic option to eliminate the use of GA3 in hybrid rice. During the past two decades, extensive work has been carried out on the subject that resulted in identification of several mutants with EUI trait for use in developing cytoplasmic/thermo-sensitive genic male-sterile lines with complete panicle exsertion (Okuno and Kawai, 1978; Rutger and Carnahan, 1981; Shen et al., 1987; Yang et al., 2000; 2002; Gangashetti et al., 2004). Two recessive genes (eui-1 and eui-2) mapped on chromosome 5 and 10 respectively have so far been reported to control the internode elongation in rice (Librojo and Khush, 1986; Yang et al., 2001; Ma et al., 2004). Considerable progress has been made in China in exploiting 'eur gene for development of hybrid rice parental lines (Yang et al., 2000; 2002; Zhang et al., 2002). 相似文献