Effect of aspirin on ex vivo generation of thromboxane in healthy horses   总被引：1，自引：0，他引：1  

G M Baxter  J N Moore 《American journal of veterinary research》1987,48(1):13-16

Different dosages of aspirin were administered (by nasogastric tube) to 3 groups of 5 healthy adult horses to determine the minimal effective dosage needed to decrease serum thromboxane B2 (TxB2) concentrations and to determine the duration of this decrease. When compared with their base-line serum TxB2 concentrations, horses in group 1 (given 5 mg/kg) had a 71% decrease in TxB2 concentrations at 24 hours after aspirin was given and a 86% decrease at 48 hours; serum TxB2 concentrations were back to base-line values by 120 hours. Horses in group 2 (given 10 mg/kg) had a 60% decrease in TxB2 concentrations at 24 hours after aspirin was given, an 84% decrease at 48 hours, a 48% decrease at 96 hours, and an 18% decrease at 6 days. Horses in group 3 (given 20 mg/kg) had a 68% decrease in TxB2 concentrations at 24 hours, a 93% decrease at 72 hours, an 87% decrease at 96 hours, and a 70% decrease at 6 days after aspirin treatment was given. All groups had a statistically significant decrease in TxB2 concentrations (P less than 0.05) by 12 hours after aspirin was given, which persisted 96 hours for group 1 and throughout the study for groups 2 and 3. The maximal TxB2 decrease was similar among the 3 groups (90% decrease from base line), and there were no significant differences among the TxB2 concentrations between 24 and 72 hours after treatment was given.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

What is your diagnosis? Nonneoplastic myelofibrosis of the medullary cavity     

Rosser J  Baxter GM 《Journal of the American Veterinary Medical Association》2007,231(5):695-696

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Cellular site of glucocorticoid-receptor complex formation   总被引：2，自引：0，他引：2  

B B Levinson  J D Baxter  G G Rousseau  G M Tomkins 《Science (New York, N.Y.)》1972,175(18):189-190

The cellular site of binding of dexamethasone by specific glucocorticoid receptors in cultured hepatoma cells was investigated with the use of certain mercurials. p-Chloromercuribenzene sulfonate and p-chloromercuribenzoate inhibit the binding of steroid by receptors in cell-free extracts, but they allow the steroid-receptor complex to form in whole cells. In contrast, HgCl(2) inhibits binding both in extracts and cells. Since both organic mercury compounds, unlike HgCl(2), do not readily enter intact cells, it appears that the specific steroid binding occurs inside the cell rather than at the cell membrane.  相似文献   

The confidential enquiry into perioperative equine fatalities (CEPEF): mortality results of Phases 1 and 2   总被引：3，自引：0，他引：3  

GM Johnston  JK Eastment  JLN Wood  & PM Taylor 《Veterinary anaesthesia and analgesia》2002,29(4):159-170

Objectives To document the equine perioperative mortality rate and to highlight any factor associated with an increased risk of death up to 7 days after anaesthesia. Study design A prospective observational epidemiological multicentre study. Methods Data were recorded from all equidae undergoing general anaesthesia in 62 clinics. Power calculations indicated that 45 000 cases were required to detect the significance of important variables. Details of each horse, operation, anaesthetic agents and clinic personnel were recorded. Outcome at 7 days was recorded as: alive, put to sleep (PTS) or dead. Data were analysed by a standard multilevel logistic regression approach, considering the effects of clustering at the level of clinic. Results Data were collected from 41 824 cases over 6 years. A total of 39 025 (93.3%) were alive on day 7 and 785 were dead giving an overall death rate of 1.9% (95% CI: 1.8–2.0) and 2014 (4.8%) were PTS. About 5846 horses undergoing emergency abdominal surgeries (‘colics’) were excluded from subsequent analyses. A total of 35 107 ‘noncolic’ horses were alive at 7 days and 328 dead giving a death rate for noncolics of 0.9% (95% CI: 0.8–1.0). Five hundred and forty‐three (1.5%) noncolic horses classified PTS were excluded from further analyses. There were 109 (33%) deaths from cardiac arrest or post‐operative cardiovascular collapse, with 107 (32%) from fractures and myopathies. Fracture repair, out of hours surgery, and age below 1 month was associated with increased risk of dying whereas the use of acepromazine and intravenous anaesthetic agent maintenance of anaesthesia was associated with reduced risk. Conclusions A number of potential contributors to the high risk of anaesthetic‐related mortality have been identified. Further investigation of the underlying mechanism for their apparent harmful effects and development of alternative techniques is merited.  相似文献   

Psychrotrophic meat spoilage fungi within a freezing works     

M. Baxter M.Sc. Ph.D.  Gaylene M. Illston B.Sc. 《New Zealand veterinary journal》2013,61(8):177-180

Extract

The contamination of refrigerated and chilled meats with microbial growths has been of concern ever since the 1880s when micro-organisms possessing the ability to survive and grow at low temperatures were first incriminated as causative agents of the contamination. The first microbial organisms described on meat at low temperatures were bacterial and it would seem that at present bacteria are still the most important agents of meat spoilage. Spoilage by fungi is less well known, but occasional consignments are still encountered that show visible mould growth.  相似文献   

Are invasive and native trout functionally equivalent predators? Results and lessons from a field experiment     

Kurt D. Fausch  Colden V. Baxter 《水产资源保护:海洋与淡水生态系统》2012,22(6):787-798

Cellular and extracellular vesicular origins of miRNAs within the bovine ovarian follicle          下载免费PDF全文

GM Andrade  FV Meirelles  JC da Silveira 《Reproduction in domestic animals》2017,52(6):1036-1045

The ovarian follicle components must provide an ideal environment to ensure the success of reproductive processes, and communication between follicular cells is crucial to support proper oocyte growth. Recently, it has been demonstrated that the presence of extracellular vesicles (EVs) carrying microRNAs (miRNAs) in follicular fluid represents an important autocrine and paracrine communication mechanism inside the ovarian follicle. In this study, we tested the hypothesis that the miRNA content of EVs isolated from ovarian follicular (granulosa and cumulus–oocyte complexes) cell‐conditioned culture media is dependent upon cell type. We initially screened bovine granulosa cells (GCs) and cumulus–oocyte complexes (COCs), as well as their derived EVs for 348 miRNAs using real‐time PCR, and detected 326 miRNAs in GCs and COCs cells and 62 miRNAs in GCs and COCs EVs. A bioinformatics analysis of the identified cell‐specific and differentially expressed miRNAs predicted that they likely modulate important cellular processes, including signalling pathways such as the PI3K‐Akt, MAPK and Wnt pathways. By investigating the origins of miRNAs within the follicular fluid, the results of this study provide novel insights into follicular miRNA content and intercellular communication that may be of invaluable use in the context of reproductive technologies, diagnostic of ovarian‐related diseases and/or the identification of biomarkers for oocyte and embryo quality.  相似文献   

Combining isotopic signatures of n(Sr)/n(Sr) and light stable elements (C,N, O,S) with multi-elemental profiling for the authentication of provenance of European cereal samples     

Daniel Goitom Asfaha  Christophe R. Quétel  Freddy Thomas  Micha Horacek  Bernhard Wimmer  Gerhard Heiss  Christian Dekant  Peter Deters-Itzelsberger  Stefan Hoelzl  Susanne Rummel  Christophe Brach-Papa  Marleen Van Bocxstaele  Eric Jamin  Malcolm Baxter  Katharina Heinrich  Simon Kelly  Daniela Bertoldi  Luana Bontempo  Federica Camin  Roberto Larcher  Matteo Perini  Andreas Rossmann  Antje Schellenberg  Claus Schlicht  Heinz Froeschl  Jurian Hoogewerff  Henriette Ueckermann 《Journal of Cereal Science》2011

The aim of this work (from the FP6 project TRACE) was to develop methods based on the use of geochemical markers for the authentication of the geographical origin of cereal samples in Europe (cf. EC regulations 2081/92 and 1898/06). For the first time, the potential usefulness of combining n(⁸⁷Sr)/n(⁸⁶Sr) and δ¹³C, δ¹⁵N, δ¹⁸O and δ³⁴S isotopic signatures, alone or with key element concentrations ([Na], [K], [Ca], [Cu] and [Rb], progressively identified out of 31 sets of results), was investigated through multiple step multivariate statistics for more than 500 cereal samples collected over 2 years from 17 sampling sites across Europe representing an extensive range of geographical and environmental characteristics.  相似文献   

The structure of the upper atmosphere of mars: In situ accelerometer measurements from mars global surveyor   总被引：1，自引：0，他引：1  

GM Keating  SW Bougher  RW Zurek  RH Tolson  GJ Cancro  SN Noll  JS Parker  TJ Schellenberg  RW Shane  BL Wilkerson  JR Murphy  JL Hollingsworth  RM Haberle  M Joshi  JC Pearl  BJ Conrath  MD Smith  RT Clancy  RC Blanchard  RG Wilmoth  DF Rault  TZ Martin  DT Lyons  PB Esposito  MD Johnston  al et 《Science (New York, N.Y.)》1998,279(5357):1672-1676

The Mars Global Surveyor (MGS) z-axis accelerometer has obtained over 200 vertical structures of thermospheric density, temperature, and pressure, ranging from 110 to 170 kilometers, compared to only three previous such vertical structures. In November 1997, a regional dust storm in the Southern Hemisphere triggered an unexpectedly large thermospheric response at mid-northern latitudes, increasing the altitude of thermospheric pressure surfaces there by as much as 8 kilometers and indicating a strong global thermospheric response to a regional dust storm. Throughout the MGS mission, thermospheric density bulges have been detected on opposite sides of the planet near 90 degreesE and 90 degreesW, in the vicinity of maximum terrain heights. This wave 2 pattern may be caused by topographically-forced planetary waves propagating up from the lower atmosphere.  相似文献   

Effects of lairage time on body temperature and glycogen reserves of broiler chickens held in transport modules.     

P D Warriss  T G Knowles  S N Brown  J E Edwards  P J Kettlewell  M A Mitchell  C A Baxter 《The Veterinary record》1999,145(8):218-222

Commercial broiler chickens killed in two processing plants, one in the south of England, the other in Scotland, in two seasons (winter and summer) and on two occasions in each season, were used to investigate the effects of killing the birds immediately on arrival or holding them in lairage for one, two, three or four hours. The two most important consequences of holding the birds in lairage were that their body temperature increased and their liver glycogen was depleted. The body temperature increased with the time they were held in lairage, although most of the increase occurred in the first hour and the increase was greater in summer when ambient temperatures were higher. Liver glycogen depletion became apparent after about one to two hours in lairage. No evidence was obtained that the birds were significantly dehydrated or physically stressed by being kept longer in lairage.  相似文献