Efficacy and safety of dirlotapide in the management of obese dogs evaluated in two placebo-controlled, masked clinical studies in North America     

J. A. WREN  A. A. RAMUDO  S. L. CAMPBELL  V. L. KING  J. S. EAGLESON  J. GOSSELLIN  & S. J. SUNDERLAND 《Journal of veterinary pharmacology and therapeutics》2007,30(S1):81-89

Dirlotapide was evaluated in the management of obesity in dogs in two multicenter, clinical studies in North America. A total of 335 obese dogs of various breeds were randomized to dirlotapide or placebo in a 2:1 ratio. Dirlotapide was administered orally once daily to dogs at an initial dose of 0.05 mg/kg, increased after 14 days to 0.1 (study B, label dose) or 0.2 mg/kg (study A) and then adjusted according to individual weight loss at 28-day intervals. Dogs were examined and weighed, and body condition scores (BCSs) were recorded every 28 days. Study A had three consecutive phases: weight loss (16 weeks, day 0–112); weight management (12 weeks); and post-treatment (8 weeks). Study B had a weight loss phase only. For dirlotapide-treated dogs, mean weight loss by day 112 was 11.8–14.0% compared with 3.0–3.9% for placebo ( P  = 0.0001). In study A, weight losses for dirlotapide were 19.3% after 12 weeks of weight management and 16.7% (regain of 3.4%) by 8 weeks after dirlotapide was discontinued. In both studies, dogs in both treatments had emesis, lethargy, anorexia, diarrhea, and mildly elevated hepatic transaminase activity, that resolved spontaneously with time. These were experienced more frequently with dirlotapide. Improved activity levels and BCS for >50% dogs were reported with dirlotapide. Dirlotapide was safe and effective in the reduction and management of body weight in obese dogs.  相似文献   

RELATIONSHIP OF INORGANIC PHOSPHATE FRACTIONS T O MINERALOGICAL CHANGES IN CALCINED CHRISTMAS ISLAND ROCK PHOSPHATE     

J. A. ADAMS  A. S. CAMPBELL 《European Journal of Soil Science》1973,24(2):215-223

A close relationship exists between inorganic phosphorus fractions and mineralogical changes in ‘C’-grade Christmas Island rock phosphate calcined at temperatures up to 1100 °C. Amounts of acid-extractable Ca-P closely followed the presence and crystallization of calcium phosphates. Amounts of NH₄F-P were related to the presence of simple aluminium phosphates. The ammonium fluoride reagent did not extract more complex aluminium phosphates such as crandallite and millisite. These minerals were considered to be present in the 2nd NaOH-P and residual-P fractions. NH₄F-P plus acid-extractable Ca-P was closely related to radish growth responses.  相似文献   

GONG Observations of Solar Surface Flows     

DH Hathaway  PA Gilman  JW Harvey  F Hill  RF Howard  HP Jones  JC Kasher  JW Leibacher  JA Pintar  GW Simon 《Science (New York, N.Y.)》1996,272(5266):1306-1309

Doppler velocity observations obtained by the Global Oscillation Network Group (GONG) instruments directly measure the nearly steady flows in the solar photosphere. The sun's differential rotation is accurately determined from single observations. The rotation profile with respect to latitude agrees well with previous measures, but it also shows a slight north-south asymmetry. Rotation profiles averaged over 27-day rotations of the sun reveal the torsional oscillation signal-weak, jetlike features, with amplitudes of 5 meters per second, that are associated with the sunspot latitude activity belts. A meridional circulation with a poleward flow of about 20 meters per second is also evident. Several characteristics of the surface flows suggest the presence of large convection cells.  相似文献   

Diathelic immunization: a maternal-offspring relationship involving milk antibodies     

CAMPBELL B  SARWAR M  PETERSEN WE 《Science (New York, N.Y.)》1957,125(3254):932-933

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Establishment of legumes in grass swards: effects of pesticides on slugs,insects, legume seedling numbers and forage yield and quality*     

R. A. BYERS  W. C. TEMPLETON  R. L. MANGAN  D. L. BIERLEIN  W. F. CAMPBELL  H. J. DONLEY 《Grass and Forage Science》1985,40(1):41-48

Three legumes, red clover (Trifolium pratense L.), alfalfa (Medicago sativa L.) and birdsfoot trefoil (Lotus corniculatus L.), were planted with a minimum-tillage drill into eight grass fields, three in early spring, two in late spring and three in late summer, in Pennsylvania. The objective was to use pesticides at planting time to control slugs and insects which attack legume seedlings and ascertain whether pest control prevented seedling loss and increased yields of grass and legume dry matter (DM), in vitro DM digestibility and crude protein (CP). Methiocarb bait alone or in combination with carbofuran granules or spray applied at planting sometimes controlled the slugs Derocerus reticulatum (Müller), D. laeve (Müller) and Arion fasciatus Nilsson and improved establishment of seedling red clover and alfalfa but not birdsfoot trefoil. Increased yields of DM, digestible DM, CP and legume DM after treatment was greatest in late-spring sowings. Larvae of the clover root curculio, Sitona hispidulus (F.), attacked roots of legumes in the spring following the year of sowing. Late spring and summer sowings without pesticides sustained considerable seedling losses from pests, whereas seedlings from early spring sowings in untreated areas were injured less.  相似文献   

Prophylactic and therapeutic efficacy of Australian‐registered insecticide formulations against Old World screwworm (Chrysomya bezziana) infestation          下载免费PDF全文

PJ James  AH Wardhana  GW Brown  DG Mayer  R Urech 《Australian veterinary journal》2017,95(8):265-272

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