Anti-inflammatory drugs inhibit degradation of equine synovial fluid induced by free radicals     

DE AUER  JC NG  JS REILLY  AA SEAWRIGHT 《Australian veterinary journal》1991,68(12):403-405

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Evidence of dehydration and electrolyte disturbances in cases of perennial ryegrass toxicosis in Australian sheep     

MDA Combs  D Rendell  KFM Reed  WJ Mace  JC Quinn 《Australian veterinary journal》2014,92(4):107-113

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The Effects of Isoflavones on Androgens and Glucocorticoids During Puberty on Male Wistar Rats     

S Caceres  G Silvan  L Martinez‐Fernandez  MJ Illera  P Millan  B Monsalve  L Peña  JC Illera 《Reproduction in domestic animals》2014,49(4):611-617

Isoflavones are the most common phytoestrogens found in human diets. However, it is still not clear whether isoflavones have effects on the reproductive and the endocrine systems under normal dietary intake and overdose. The aim of this study was to determine how the most important isoflavones, genistein and daidzein, affect androgen and glucorticoid levels on male prepuberal rats. A hundred and seventy‐five 30‐day‐old male Wistar rats were dosed orally by stomach tube every day for 35 days, with saline solution, low and high doses of genistein, daidzein and a mixture of both. Serum samples were analysed by an enzyme immunoassay for hormone determinations. In control group, there was a peak of testosterone (T) and dihydrotestosterone levels associated to the onset of puberty, at the third week. However, in low‐dose groups, the same peak was found at the fourth week (p < 0.05), indicating a delay in the onset of puberty in these groups. Moreover, high doses groups serum androgen levels were significantly lower (p < 0.05) than the control group from the first week until fifth week. This fact was supported by a epididymal histological analysis that indicate in low doses there were several content of spermatozoa at fourth week and in high doses there were few content of spermatozoa. Besides, corticosterone levels followed the same pattern of androgens in all groups. We can conclude that oral administration of isoflavones in male rats decreased the secretion of androgens and glucocorticoids causing a delay in the onset of puberty and may cause physiological and developmental problems.  相似文献   

Surgical management and long-term outcome of dogs with cervical spondylomyelopathy with an anchored intervertebral titanium device     

JC King  GS Corfield  JG Mouatt  CY Kan  PA Moses 《Australian veterinary journal》2020,98(4):156-163

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The effect of unilateral eyestalk ablation and diet on the reproductive performance of wild-caught Farfantepenaeus aztecus (Ives, 1891) using a closed recirculating maturation system     

Ryan L Gandy  Tzachi M Samocha  Michael P Masser  Joe M Fox  Abdul-Mehdi S Ali  Delbert M Gatlin III  & Michael Speed 《Aquaculture Research》2007,38(6):580-587

Two studies were conducted to evaluate the effects of unilateral eyestalk ablation and diet on the reproductive performance of wild populations of Farfantepenaeus aztecus. In both studies, females in two treatments were unilaterally ablated while those in the control treatment were not. Shrimp in the non‐ablated treatment and one of the unilaterally ablated treatments received frozen bloodworms (8% BW day⁻¹) and frozen squid (12% BW day⁻¹). The bloodworm component of the diet of the third unilateral ablation treatment was replaced with frozen adult enriched Artemia sp. Ablated female population spawning per night, in both studies, was higher than non‐ablated spawning (8.5 and 8.9 vs. 2.6%; 7.4 and 7.5 vs. 2.7% respectively; P<0.05). Replacement of bloodworms with adult enriched Artemia sp. had no negative effect on the number of eggs spawned per ablated female (124 000 vs. 115 000 eggs spawn⁻¹; 144 000 vs. 151 000 eggs spawn⁻¹ respectively; P>0.05). The life span of ablated females fed adult enriched Artemia sp. was 8 and 40 days longer than ablated females fed bloodworms for the first and second studies respectively. Replacement of bloodworms with adult enriched Artemia sp. resulted in higher hatch and larval survival rates (Nauplius 1 to Zoea 1) (55.0% vs. 46.9% and 44.8% vs. 37.2%), respectively, P<0.05.  相似文献   

Preliminary safety and biological efficacy studies of ethyl pyruvate in normal mature horses     

Schroeder EL  Holcombe SJ  Cook VL  James MD  Gandy JC  Hauptman JG  Sordillo LM 《Equine veterinary journal》2011,43(3):341-347

Reasons for performing the study: Endotoxaemia causes substantial morbidity and mortality in horses with colic and sepsis. Ethyl pyruvate is a novel anti‐inflammatory medication that improved survival in preclinical models of severe sepsis endotoxaemia and intestinal ischaemia and reperfusion in rodents, swine, sheep and dogs and may be a useful medication in horses. Hypothesis: Ethyl pyruvate has no adverse effects in normal horses and is biologically active based on suppression of proinflammatory gene expression in endotoxin stimulated whole blood, in vitro. Methods: Physical and neurological examinations, behaviour scores, electrocardiograms and clinicopathological tests were performed on 5 normal healthy horses receiving 4 different doses of ethyl pyruvate. Doses included 0, 50, 100 and 150 mg/kg bwt administered in a randomised crossover design with a 2 week washout period between doses. Biological efficacy was assessed by stimulating whole blood with endotoxin from the horses that received ethyl pyruvate prior to and 1 and 6 h after drug infusion. Gene expression for TNFα, IL‐1β and IL‐6 was assessed. Results: There were no effects of drug or dose (0, 50, 100 or 150 mg/kg bwt) on any of the physical or neurological examination, behaviour factors, electrocardiogram or clinical pathological results collected from any of the horses. All parameters measured remained within the normal reference range. There was a significant reduction in TNFα, IL‐1β and IL‐6 gene expression in endotoxin stimulated whole blood from horses 6 h after receiving 150 mg/kg bwt ethyl pyruvate. There were no detectable effects on gene expression of any of the other doses of ethyl pyruvate tested. Conclusion: We were unable to detect any detrimental effects of ethyl pyruvate administration in normal horses. Ethyl pyruvate significantly decreased proinflammatory gene expression in endotoxin stimulated blood 6 h after drug administration. Clinical relevance: Ethyl pyruvate may be a safe, effective medication in endotoxaemic horses.  相似文献   

Reply     

H. SIDJABAT-TAMBUNAN  JC BENSINK 《Australian veterinary journal》1997,75(9):676-676

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The use of chlorothalonil for the control of benzimidazole tolerant strains of Verticillium fungicola (Preuss) Hassebr. on the cultivated mushroom     

Doreen G. Gandy  D.M. Spencer 《Scientia Horticulturae》1976,5(1):13-21

Chlorothalonil (as Daconil 2787, 75 % a.i., w.p.), applied as a drench, reduced the incidence on mushrooms of Verticillium fungicola which was tolerant to certain benzimidazole fungicides. Compared with zineb, chlorothalonil gave better disease control, required only one application and did not stain sporophores. Incorporation of chlorothalonil into the casing layer caused toxicity to the crop and depressed the yield. Where tolerance was not a problem, benomyl gave better disease control than chlorothalonil.  相似文献   

Serum and Tissue Steroid Hormone Levels in Canine Mammary Tumours: Clinical and Prognostic Implications          下载免费PDF全文

FL Queiroga  D Pérez‐Alenza  A González‐Gil  G Silván  L Peña  JC Illera 《Reproduction in domestic animals》2015,50(5):858-865

Hormonal dependency of canine mammary tumours (CMT) has been studied over the last few decades. However, studies assessing the prognostic and predictive potential of serum and/or tissue steroid hormone levels are still scarce in CMT. To the best of our knowledge, this is the first report relating serum and tissue levels of steroid hormones and prognosis in dogs. Serum and tumour tissue from 45 female dogs with spontaneous CMT were included in the study. Moreover, serum and normal mammary tissue from 13 healthy female dogs were also included as controls. Steroid hormones were determined by competitive enzyme immunoassay. Overall, levels of steroid hormones in serum and tissue homogenates were significantly different between malignant and benign mammary tumours (p < 0.01), except for progesterone (P4) serum levels that revealed no statistical differences between groups. In malignant tumours, oestrone sulphate (SO4E1), dehydroepiandrosterone (DHEA), androstenedione (A4), testosterone (T) and P4 elevated tissue concentrations were significantly associated with tumour relapse and/or distant metastasis during follow‐up. A significant association was found between elevated tissue SO4E1 (p = 0.003), 17β‐oestradiol (E2) (p = 0.036), DHEA (p = 0.022), A4 (p = 0.001) and P4 (p = 0.013) concentrations and shorter disease‐free survival and overall survival in female dogs with malignant mammary tumours. The high levels of tissue steroids found in cases of poor prognosis open the possibility of additional new therapeutic approaches. Future clinical trials will be needed to clarify the usefulness of targeting steroid hormones in the treatment of this neoplastic disease.  相似文献   

Meningoencephalomyelitis in a foal due to Salmonella agona infection     

JC Patterson-Kane  FT Bain  JM Donahue  LR Harrison 《New Zealand veterinary journal》2013,61(4):159-161

CASE HISTORY: A neonatal Thoroughbred foal was presented with rib fractures and left forelimb lameness secondary to dystocia.

CLINICAL FINDINGS: The foal developed a head tilt, seizures and watery diarrhoea during hospitalisation and died at 7 days of age. Histological examination of the brain and spinal cord revealed a suppurative meningoencephalomyelitis with vasculitis, and numerous intralesional, gram-negative bacilli. Similar microscopic lesions were noted in the lungs, renal medullary interstitium, and umbilicus. Bacilli in the brain, spinal cord and umbilicus were identified immunohistochemically as Salmonella group B. Salmonella agona was isolated in pure culture from the brain, lung, liver, kidney, and intestine.

CONCLUSION: This is the first report of meningoencephalomyelitis and septicaemia due to Salmonella infection in an equine neonate.  相似文献