Infarction of the small intestine in the horse. II. Pathology and pathogenesis     

B Pauli  H Gerber  P Chuit 《Schweizer Archiv für Tierheilkunde》1971,113(12):685-696

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Bleeding abomasal ulcers in dairy cows     

U Braun  R Bretscher  D Gerber 《The Veterinary record》1991,129(13):279-284

The clinical signs and changes in blood and rumen fluid, and the results of therapy are described in 35 cows suffering from bleeding abomasal ulcer. The most important pathological findings were moderate to severe anaemia with pale mucous membranes and tachycardia, dark coloured to black faeces, a disturbed general condition and anorexia. Two of the cows were slaughtered immediately. The others were treated by the transfusion of several litres of blood and the intravenous administration of a solution containing sodium chloride and glucose and other drugs such as calcium solution, vitamin K, vitamin C and metoclopramide. Two animals died in spite of the treatment and three had to be slaughtered because of the deterioration in their condition. The other 28 cows recovered within a few days and their general condition, appetite and defecation returned to normal.  相似文献   

Seasonal appearance of ticks and piroplasms in domestic animals in the Asiatic provinces of Turkey     

G Hoffmann  F H?rchner  E Schein  H C Gerber 《Berliner und Münchener tier?rztliche Wochenschrift》1971,84(8):152-156

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Sensitization studies using dexamethasone and carboxymethylcellulose in the horse     

R Straub  S Lazary  H Gerber  A L De Weck  U Schatzmann  B Pauli 《Schweizer Archiv für Tierheilkunde》1972,114(9):439-449

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Owner‐reported coughing and nasal discharge are associated with clinical findings,arterial oxygen tension,mucus score and bronchoprovocation in horses with recurrent airway obstruction in a field setting          下载免费PDF全文

H. Rettmer  A. M. Hoffman  S. Lanz  M. Oertly  V. Gerber 《Equine veterinary journal》2015,47(3):291-295

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Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigs     

Kimberly Crawford  Kelly Lager  Laura Miller  Tanja Opriessnig  Priscilla Gerber  Richard Hesse 《Veterinary research》2015,46(1)

Clinical disease associated with porcine epidemic diarrhea virus (PEDV) infection in naïve pigs is well chronicled; however, information on endemic PEDV infection is limited. To characterize chronic PEDV infection, the duration of infectious virus shedding and development of protective immunity was determined. On Day 0 (D0), a growing pig was challenged with PEDV and 13 contacts were commingled. On D7, 9 contact pigs (principal virus group (PG)), were selected, moved to a separate room and commingled with one sentinel pig (S1). This process was repeated weekly with S2, S3 and S4. The PG was PEDV-positive by PCR from D3-11, with some pigs intermittently positive to D42. Pigs S1 and S2 were PEDV-positive within 24 hours of commingling. Antibodies were detected in all PG by D21 and by 7 days post-contact in S1 and S2. Pigs S3 and S4 were PCR and antibody negative following commingling. To evaluate protective immunity, 5 naïve pigs (N) and the PG were challenged (N/C, PG/C) with homologous virus on D49. All N/C pigs were PEDV PCR-positive by D52 with detection out to D62 in 3/5 N/C pigs. All PG/C pigs were PEDV PCR-negative post-challenge. By D63, all N/C seroconverted. Although PEDV RNA was demonstrated in pigs after primary infection until D42, infectious PEDV capable of horizontal transmission to naïve pigs was only shed 14–16 days after infection to age-matched pigs. Homologous re-challenge 49 days post initial PEDV exposure did not result in re-infection of the pigs. This demonstrates potential for an effective PEDV vaccine.  相似文献   

Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter     

Gerber S  Comellas-Bigler M  Goetz BA  Locher KP 《Science (New York, N.Y.)》2008,321(5886):246-250

Transport across cellular membranes is an essential process that is catalyzed by diverse membrane transport proteins. The turnover rates of certain transporters are inhibited by their substrates in a process termed trans-inhibition, whose structural basis is poorly understood. We present the crystal structure of a molybdate/tungstate ABC transporter (ModBC) from Methanosarcina acetivorans in a trans-inhibited state. The regulatory domains of the nucleotide-binding subunits are in close contact and provide two oxyanion binding pockets at the shared interface. By specifically binding to these pockets, molybdate or tungstate prevent adenosine triphosphatase activity and lock the transporter in an inward-facing conformation, with the catalytic motifs of the nucleotide-binding domains separated. This allosteric effect prevents the transporter from switching between the inward-facing and the outward-facing states, thus interfering with the alternating access and release mechanism.  相似文献   

Production of Lipase Using Cassava Peel and Sunflower Oil in Solid-State Fermentation： Preliminary Study     

Caroline Branco Gerber  Francieli Kaufmann  Gabrieli Nicoletti  Marilia Dalla Costa  Aniela PintoKempka 《农业科学与技术》2013,(12):948-954

Full use of residues from industrial processes is a fundamental necessity of contemporary society, since it avoids impacts to the environment by using residues as inputs for other products of high economic and social importance. In this study, lipase production of the crude enzymatic extracts obtained by Aspergillus niger using cassava peel as substrate and sunflower oil as an inductor was investigated. The optimized cultivation temperature and concentration of inductor were determined using the response surface methodology. The two variables studied exercised influence in the production of lipase in the 95% level of confidence. The response surface obtained indicated that the conditions that maximize lipase activity production were 30.5 ~C and initial concentration of sunflower oil was 2.5% （w/w）. Through this analysis, it is evident that extremes in temperature and concentration of inductor tend to decrease lipase production, since low temperatures decrease metabolism and high temperatures may inactivate the lipase. Optimum lipase yield was 59.8 U/g of dry peel which was fermented for 60 h. Lipase production presents a peak of 61.3 U/g, at 72 h of fermentation. However, this value is statistically equal （p 〉 0.05） of the value of lipase activity obtained for 60 h and 84 h of fermentation.  相似文献   

Confirmed Datura poisoning in a horse most probably due to D. ferox in contaminated tef hay     

Gerber R  Naudé TW  de Kock SS 《Journal of the South African Veterinary Association》2006,77(2):86-89

Two out of a group of 23 mares exposed to tef hay contaminated with Datura ferox (and possibly D. stramonium) developed colic. The 1st animal was unresponsive to conservative treatment, underwent surgery for severe intestinal atony and had to be euthanased. The 2nd was less seriously affected, responded well to analgesics and made an uneventful recovery. This horse exhibited marked mydriasis on the first 2 days of being poisoned and showed protracted, milder mydriasis for a further 7 days. Scopolamine was chemically confirmed in urine from this horse for 3 days following the colic attack, while atropine could just be detected for 2 days. Scopolamine was also the main tropane alkaloid found in the contaminating plant material, confirming that this had most probably been a case of D. ferox poisoning. Although Datura intoxication of horses from contaminated hay was suspected previously, this is the 1st case where the intoxication could be confirmed by urine analysis for tropane alkaloids. Extraction and detection methods for atropine and scopolamine in urine are described employing enzymatic hydrolysis followed by liquid-liquid extraction and liquid chromatography tandem mass spectrometry (LC/MS/MS).  相似文献   

Evaluation of the effects of performance dentistry on equine rideability: a randomized,blinded, controlled trial     

Sébastien Moine  Shannon Axiak Flammer  Päivi de Jesus Maia-Nussbaumer  Micaël D. Klopfenstein Bregger  Vincent Gerber 《The Veterinary quarterly》2017,37(1):195-199

Objective: This study attempted to determine: (1) if degree of dental malocclusion assigned prior to dental treatment was associated with equine rideability, assessed using a standardized score and (2) if performance dentistry improved this score.

Animals: Thirty-eight Franches-Montagnes stallions.

Methods: All horses were examined and assigned a dental malocclusion score by a veterinary dentist and randomized into two groups: sham treatment (Group S) and performance dentistry including occlusal equilibration (Group D). The horses were ridden twice before and three times after treatment by a professional dressage rider (unaware of treatment allocation). The horses were assigned a rideability score using a 27-point scale. The malocclusion score was compared to the average of the first two rideability scores using Spearman's coefficient of rank. Change in rideability scores over time was assessed by repeated measures ANOVA. Statistical significance was set at P < 0.05.

Results: There was no correlation between dental score and rideability score prior to treatment (r_s = 0.06, P = 0.73). In addition, there were no differences in the rideability score between treatment groups or as an interaction of treatment group and time (P = 0.93, P = 0.83, respectively).

Conclusions: In conclusion, we were unable to show that performance dentistry improved equine rideability assessed by rider scoring. The addition of more objective measurement tools and a longer assessment period may help to scientifically prove what is anecdotally believed.  相似文献