Johne's disease in alpacas (Lama pacos) in Australia     

SE RIDGE  JT HARKIN† ‡  RT BADMAN†  AM MELLOR§  JWA LARSEN¶ 《Australian veterinary journal》1995,72(4):150-153

SUMMARY: Johne's disease was diagnosed in 10 alpacas ( Lama pacos ) in Australia between February 1993 and May 1994. Eight of the animals were between 12 and 24 months of age, one was a 6-year-old female, and one was a 4-year-old male. Five, including the 6-year-old and the 4-year-old alpacas, showed weight loss and diarrhoea before death or slaughter. The other cases showed no clinical signs of Johne's disease but 4 gave a positive result on faecal culture and one gave a positive result on testing with the caprine ACID assay and had acid-fast organisms in its faeces. At necropsy, all cases had grossly enlarged mesenteric lymph nodes. Johne's disease was diagnosed after histological examination of the lymph nodes with conventional culture and polymerase chain reaction testing of tissue samples. This report outlines the clinical, epidemiological, and pathological findings in these cases.  相似文献   

Effects of terbinafine on growth, squalene, and steryl ester content of a celery cell suspension culture     

P. J. Yates  P. A. Haughan  J. R. Lenton  L. J. Goad   《Pesticide biochemistry and physiology》1991,40(3)

The allylamine terbinafine inhibited growth of a celery (Apium graveolens) cell suspension culture (I₅₀ = 90 μM) and blocked the action of squalene epoxidase, resulting in an accumulation of squalene and a decrease in the sterol content of the cells. Celery cells were tolerant to squalene accumulation; inhibition of growth of cultures was associated with a fall in the free sterol content below about 1 μg sterol/mg dry wt of cells. At Day 14, untreated celery cells contained about 60% of the total sterol in the esterified form. However, the steryl ester pool was considerably lower in terbinafine-treated cells which may reflect an attempt to maintain the free sterol content above a threshold value. The composition of free sterols of terbinafine-treated cells was different from control cultures, suggesting that terbinafine has a second site of inhibition on the pathway to major sterols in plants.  相似文献   

Effects of Dietary Supplementation of β‐hydroxy‐β‐methylbutyrate on Sow Performance and mRNA Expression of Myogenic Markers in Skeletal Muscle of Neonatal Piglets          下载免费PDF全文

HF Wan  JT Zhu  Y Shen  X Xiang  HJ Yin  ZF Fang  LQ Che  Y Lin  SY Xu  B Feng  D Wu 《Reproduction in domestic animals》2016,51(1):135-142

The effects of dietary β‐hydroxy‐β‐methylbutyrate (HMB) supplementation during gestation on reproductive performance of sows and the mRNA expression of myogenic markers in skeletal muscle of neonatal pigs were determined. At day 35 of gestation, a total of 20 sows (Landrace × Yorkshire, at third parity) were randomly assigned to two groups, with each group receiving either a basal diet or the same diet supplemented with 4 g/day β‐hydroxy‐β‐methylbutyrate calcium (HMB‐Ca) until parturition. At parturition, the total and live litter size were not markedly different between treatments, however, the sows fed HMB diet had a decreased rate of stillborn piglets compared with the sows fed the control (CON) diets (p < 0.05). In addition, piglets from the sows fed HMB diet tended to have an increased birth weight (p = 0.08), and a reduced rate of low birth weight piglets (p = 0.05) compared with piglets from the CON sows. Nevertheless, lower feed intake during lactation was observed in the sows fed the HMB diet compared with those on the CON diet (p < 0.01). The relative weights of the longissimus dorsi (LD) and semitendinosus (ST) muscle were higher (p < 0.05) in neonatal pigs from the HMB than the CON sows. Furthermore, maternal HMB treatment increased the mRNA levels of the myogenic genes, including muscle regulatory factor‐4 (MRF4, p < 0.05), myogenic differentiation factor (MyoD) and insulin‐like growth factor‐1 (IGF‐1, p < 0.01). In conclusion, dietary HMB supplementation to sows at 4 g/day from day 35 of gestation to term significantly improves pregnancy outcomes and increases the expression of myogenic genes in skeletal muscle of neonatal piglets, but reduces feed intake of sows during lactation.  相似文献   

Antigen Concentrations as an Indicator of Clinical Remission and Disease Relapse in Cats with Histoplasmosis          下载免费PDF全文

A.S. Hanzlicek  J.H. Meinkoth  J.S. Renschler  C. Goad  L.J. Wheat 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2016,30(4):1065-1073

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Pathogenicity of Ostertagia circumcincta,O. ostertagi and H. contortus in weanling stag fawns (Cervus elaphus)     

JT Johnson  AS Familton  R McAnulty  AR Sykes 《New Zealand veterinary journal》2013,61(12)

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Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs     

Deparle LA  Gupta RC  Canerdy TD  Goad JT  D'Altilio M  Bagchi M  Bagchi D 《Journal of veterinary pharmacology and therapeutics》2005,28(4):385-390

DeParle L. A., Gupta R. C., Canerdy T. D., Goad J. T., D'Altilio M., Bagchi M., Bagchi D. Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs. J. vet. Pharmacol. Therap.28, 385-390.In large breed dogs, arthritis is very common because of obesity, injury, aging, immune disorder, or genetic predispositions. This study was therefore undertaken to evaluate clinical efficacy and safety of undenatured type-II collagen (UC-II) in obese-arthritic dogs. Fifteen dogs in three groups received either no UC-II (Group I) or UC-II with 1 mg/day (Group II) or 10 mg/day (Group III) for 90 days. Lameness and pain were measured on a weekly basis for 120 days (90 days treatment plus 30 days post-treatment). Blood samples were assayed for creatinine and blood urea nitrogen (markers of renal injury); and alanine aminotransferase and aspartate aminotransferase (evidence of hepatic injury). Dogs receiving 1 mg or 10 mg UC-II/day for 90 days showed significant declines in overall pain and pain during limb manipulation and lameness after physical exertion, with 10 mg showed greater improvement. At either dose of UC-II, no adverse effects were noted and no significant changes were noted in serum chemistry, suggesting that UC-II was well tolerated. In addition, dogs receiving UC-II for 90 days showed increased physical activity level. Following UC-II withdrawal for a period of 30 days, all dogs experienced a relapse of overall pain, exercise-associated lameness, and pain upon limb manipulation. These results suggest that daily treatment of arthritic dogs with UC-II ameliorates signs and symptoms of arthritis, and UC-II is well tolerated as no adverse effects were noted.  相似文献   

The write stuff     

JT FARAGHER 《Australian veterinary journal》1998,76(2):108-109

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Parameters of the Reproductive Tract,Spermatogenesis, Daily Sperm Production and Major Seminal Plasma Proteins of Tropically Adapted Morada Nova Rams     

FML Sousa  CH Lobo  ESB Menezes  JPA Rego  RV Oliveira  AC Lima‐Souza  M Fioramonte  FC Gozzo  RCFF Pompeu  MJD Cândido  JT Oliveira  AA Moura 《Reproduction in domestic animals》2014,49(3):409-419

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Topoedaphic Variability and Patch Burning in Sand Sagebrush Shrubland     

Stephen L. Winter  Samuel D. Fuhlendorf  Carla L. Goad  Craig A. Davis  Karen R. Hickman 《Strength and Conditioning Journal》2011,64(6):633-640

Patch burning is the deliberate application of fire to a management unit in a heterogeneous manner, resulting in the heterogeneous distribution of grazing animal impact. The application of patch burning typically has been discussed within a framework of imposing heterogeneity on a homogeneous landscape or management unit, yet most landscapes and management units are actually distinguished by an inherent level of heterogeneity. Within landscapes and management units, differing topography and soils interact to create patterns of contrasting patches, also known as topoedaphic sites. Thus, introduction of a heterogeneous disturbance such as patch burning on a landscape or management unit is more accurately described as the imposition of one layer of heterogeneity onto a pre-existing layer of heterogeneity. We examined effects of patch burning on vegetation structure and animal distribution across contrasting topographical sites in sand sagebrush (Artemisia filifolia Torr.) shrubland of the southern Great Plains in North America. Landscapes at our study site were characterized by an inherent amount of heterogeneity in vegetation structure due to variability in topoedaphic sites, and the patch burning treatment superimposed additional heterogeneity that was constrained by topoedaphic characteristics. Shrub-dominated sites were more dependent on patch burning for heterogeneity of vegetation structure than sites dominated by short grasses. Distribution patterns of cattle (Bos taurus) were not significantly different across treatments, though they followed patterns similar to previous studies. We demonstrated that heterogeneity was dependent on topoedaphic patterns and the application of patch burning management for heterogeneity was dependent on the inherent variability of a landscape.  相似文献   

Investigations into the toxicity of Echium plantagineum in sheep: 1. Field grazing experiments     

JT SEAMAN  WS TURVEY  SJ OTTAWAY  AR GILMOUR  RJ DIXON† 《Australian veterinary journal》1989,66(9):279-285

A field grazing trial was undertaken to monitor the health and production of crossbred sheep grazing pasture where Echium plantagineum constituted a considerable proportion of the available forage. The trial, conducted for 19 months over successive grazing seasons, demonstrated a significant difference in production, with sheep on the E. plantagineum pasture being lighter and growing less wool compared with sheep on Echium-free pasture. No mortalities involving pyrrolizidine alkaloid poisoning were recorded in sheep grazing E. plantagineum, although there was histological evidence of moderately severe liver damage associated with high liver copper concentrations in at least one sheep following the grazing of large quantities of the plant.  相似文献