Observations on the biology and control of the chewing louse (Bovicola limbata) of Angora goats in Great Britain.     

P Bates  M Rankin  W Cooley  B Groves 《The Veterinary record》2001,149(22):675-676

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Cercopithecus and company: a primate radiation     

Groves CP 《Science (New York, N.Y.)》1989,244(4906):860-861

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes   总被引：1，自引：0，他引：1  

Zeggini E  Weedon MN  Lindgren CM  Frayling TM  Elliott KS  Lango H  Timpson NJ  Perry JR  Rayner NW  Freathy RM  Barrett JC  Shields B  Morris AP  Ellard S  Groves CJ  Harries LW  Marchini JL  Owen KR  Knight B  Cardon LR  Walker M  Hitman GA  Morris AD  Doney AS;Wellcome Trust Case Control Consortium 《Science (New York, N.Y.)》2007,316(5829):1336-1341

The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set out to detect replicated diabetes association signals through analysis of 3757 additional cases and 5346 controls and by integration of our findings with equivalent data from other international consortia. We detected diabetes susceptibility loci in and around the genes CDKAL1, CDKN2A/CDKN2B, and IGF2BP2 and confirmed the recently described associations at HHEX/IDE and SLC30A8. Our findings provide insight into the genetic architecture of type 2 diabetes, emphasizing the contribution of multiple variants of modest effect. The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes.  相似文献   

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity   总被引：2，自引：0，他引：2  

Frayling TM  Timpson NJ  Weedon MN  Zeggini E  Freathy RM  Lindgren CM  Perry JR  Elliott KS  Lango H  Rayner NW  Shields B  Harries LW  Barrett JC  Ellard S  Groves CJ  Knight B  Patch AM  Ness AR  Ebrahim S  Lawlor DA  Ring SM  Ben-Shlomo Y  Jarvelin MR  Sovio U  Bennett AJ  Melzer D  Ferrucci L  Loos RJ  Barroso I  Wareham NJ  Karpe F  Owen KR  Cardon LR  Walker M  Hitman GA  Palmer CN  Doney AS  Morris AD  Smith GD  Hattersley AT  McCarthy MI 《Science (New York, N.Y.)》2007,316(5826):889-894

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.  相似文献   

Production of Oocytes of Nile Tilapia (Oreochromis niloticus) for In Vitro Fertilization via Hormonal Treatments     

DAA Oliveira  CG Aleixo  SA Prado  RK Luz  NLAF Sarmento  EA Teixeira  MR Luz  EM Turra 《Reproduction in domestic animals》2013,48(6):1049-1055

Only a few studies have described hormonal treatments for induction of synchronicity and gamete collection in Nile tilapia (Oreochromis niloticus), both important for assortative matings in breeding programmes and essential for polyploidy technologies. In this study, we compared the effectiveness of carp pituitary extract (CPE), Nile tilapia pituitary extract (TPE), human chorionic gonadotropin (hCG) and gonadotropin‐releasing hormone (GnRH) protocols on the induction of spawning and egg production in Nile tilapia. Among the hormonal treatments analysed, only hCG was effective for producing viable gametes for in vitro fertilization. To verify the viability of this hormonal treatment, hCG was tested using different doses (1000, 2000, 3000, 4000 and 5000 IU/kg) in a large number of females (208 animals) from two Nile tilapia lines. The results indicated that hCG doses between 1000 and 5000 IU/kg could be used to induce final oocyte maturation in Nile tilapia with collection of stripped oocytes. This is the first study to report differential reproductive responses to hormonal treatment between tilapia lines: line 1 was more efficient at producing eggs and post‐hatching larvae after hCG induction than line 2. In conclusion, we demonstrated that the hCG protocol may be applied on a large scale to induce final oocyte maturation in Nile tilapia. The development of a protocol for in vitro fertilization in Nile tilapia may aid in breeding programmes and biotechnological assays for the development of genetically modified lines of Nile tilapia.  相似文献   

Evaluation of diamide insecticides co‐applied with other agrochemicals at various times to manage Ostrinia nubilalis in processing snap bean          下载免费PDF全文

Anders S Huseth  Russell L Groves  Scott A Chapman  Brian A Nault 《Pest management science》2015,71(12):1649-1656

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Effects of meiotic inhibitors and gonadotrophins on porcine oocytes in vitro maturation,fertilization and development          下载免费PDF全文

MA Gil  A Nohalez  CA Martinez  JR Ake‐Villanueva  F Centurion‐Castro  C Maside  C Cuello  J Roca  I Parrilla  EA Martinez 《Reproduction in domestic animals》2017,52(5):873-880

This study evaluated the effect of three reversible meiotic inhibitors (MINs) and their interaction with gonadotrophins (Gns) on the meiotic maturation and developmental competence of porcine oocytes. In experiment 1, the oocytes were matured for 22 hr in the presence or absence of dbcAMP (1 mM), cycloheximide (7 μM) or cilostamide (20 μM) with or without Gns, and for an additional 22 hr in the absence of MINs and Gns. At 22 hr of maturation, regardless of the presence of Gns, a higher proportion (p < .001) of oocytes cultured in the presence of MINs were effectively arrested at the germinal vesicle stage compared with the oocytes cultured without MINs. At 44 hr of maturation, the proportion of oocytes that reached MII was higher (p < .05) in groups with Gns compared with groups without Gns. In experiment 2, oocytes that were matured as in experiment 1 were inseminated and cultured for 7 days to evaluate fertilization parameters and blastocyst formation. Only oocytes from the dbcAMP + Gns group had higher (p < .05) efficiency of fertilization compared with the other treatment groups. The presence of dbcAMP during maturation also increased (p < .05) blastocyst formation and efficiency of blastocyst formation in both the presence and absence of Gns. These results indicate that the interaction of Gns with the tested MINs improved meiotic progression. In addition, regardless of supplementation with Gns, the presence of dbcAMP during the first maturation period increased and even doubled the capacity of oocytes to develop to the blastocyst stage.  相似文献   

Cardiac troponin I in cats with hypertrophic cardiomyopathy     

Connolly DJ  Cannata J  Boswood A  Archer J  Groves EA  Neiger R 《Journal of Feline Medicine and Surgery》2003,5(4):209-216

The molecular structure of cardiac troponin I (cTnI) is highly conserved across mammalian species and assays developed for its measurement in human patients have been validated in a number of veterinary species. A raised concentration of circulating cTnI is a sensitive and specific marker of cardiac myocyte injury. Raised levels have been documented in a variety of cardiac diseases in both human and veterinary patients. This study compared serum cTnI concentrations between 16 cats diagnosed with hypertrophic cardiomyopathy (HCM) using echocardiography and 18 control cats. The results show that cats with HCM have significantly higher concentration of serum cTnI (median 0.95 ng/ml, range 0.2-4.1 ng/ml) than control cats (median <0.2 ng/ml, range <0.2-0.25 ng/ml) [P<0.0001]. Furthermore in cats with cardiomyopathy a weak correlation was found between the thickness of the left ventricular freewall in diastole measured by ultrasound and serum cTnI concentration (r(2)=0.28;P=0.036). These results suggest that measurement of serum cTnI concentration may enable cats with cardiomyopathy to be distinguished from normal cats using the assay described here.  相似文献   

Challenges in Pig Artificial Insemination   总被引：4，自引：0，他引：4  

J Roca  JM Vázquez  MA Gil  C Cuello  I Parrilla  EA Martínez 《Reproduction in domestic animals》2006,41(S2):43-53

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Commercial Fungicide Formulations Induce In Vitro Oospore Formation and Phenotypic Change in Mating Type in Phytophthora infestans     

Groves CT  Ristaino JB 《Phytopathology》2000,90(11):1201-1208

ABSTRACT A wide range of commercially formulated fungicides cause in vitro effects on mating behavior in specific isolates of Phytophthora infestans, the causal agent of late blight of potato and tomato. Four isolates of P. infestans representing each of the four common US genotypes, US-1, US-6, US-7, and US-8 and varying in their sensitivity to metalaxyl, were exposed to a variety of fungicides used to control late blight in petri dish assays at concentrations ranging from 1 to 100 mug a.i./ml. Exposure of each of these normally heterothallic single mating type isolates of P. infestans to 9 of the 11 commercial fungicide formulations tested resulted in the formation of oospores after 2 to 4 weeks. The highest numbers of oospores were formed on media amended with Ridomil 2E (metalaxyl) and Ridomil Gold EC (mefenoxam) at 0.1 to 10 mug a.i./ml, averaging as many as 471 and 450 oospores per petri dish, respectively. Several other fungicides including Maneb, Manzate (Mancozeb), Curzate (cymoxanil + mancozeb), and Acrobat MZ (dimethomorph + mancozeb) also induced oospore formation, producing from 0 to 200 oospores per plate at fungicide concentrations from 0.1 to 10 mug a.i./ml. The metalaxyl resistant isolates formed oospores in response to the fungicides more often than the metalaxyl sensitive isolates. No oospores were formed on media amended with Bravo (chlorothalonil) or Tattoo C (chlorothalonil + propamocarb HCl) and these compounds completely suppressed growth of the isolates at 0.1 and 1 mug a.i./ml. Three metalaxyl resistant A2 isolates mated with both A1 and A2 isolates after exposure to the fungicides Ridomil 2E and Ridomil Gold EC. Alterations in mating type expression were also observed in a metalaxyl sensitive A1 isolate after exposure to Benlate (benomyl). Copious amounts of chemicals are applied annually to potato and tomato production areas to control late blight. Our results indicate that a wide range of chemically diverse fungicides can induce normally heterothallic metalaxyl resistant isolates of P. infestans to form oospores in vitro after short exposures to the fungicides.  相似文献