Strangulating obstruction of the small intestine by a fibrous band originating on the nephrosplenic ligament     

M. Gandini  F. Labate  A. Rosso  G. Giusto 《Equine Veterinary Education》2021,33(5):e146-e148

During a laparotomy for colic signs in a 2-year-old male Thoroughbred, a portion of approximately 7 m of the jejunum was found entrapped in a fibrous band originating from the nephrosplenic ligament. The entrapped jejunum was necrotic and was removed. Two months after the first surgery, a laparoscopy was performed to close the nephrosplenic space and it was possible to identify several fibrous bands bridging from the renal capsule to the splenic capsule and a fibrotic plate over the spleen. This is the first report of a strangulating obstruction of the jejunum in the nephrosplenic space and of fibrous bands bridging from the nephrosplenic ligament to the spleen. The fibrous bands were likely due to inflammation caused by previous, multiple left dorsal displacements of the bowel, which resolved spontaneously.  相似文献   

Segmental meningomyelitis in 2 cats caused by Toxoplasma gondii     

Alves L  Gorgas D  Vandevelde M  Gandini G  Henke D 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2011,25(1):148-152

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An anaesthetic combination of ketamine, xylazine and alphaxalone-alphadolone in ostriches (Struthio camelus)     

G C Gandini  R H Keffen  R E Burroughs  H Ebedes 《The Veterinary record》1986,118(26):729-730

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Acromegaly due to a somatroph adenoma in a dog     

Fracassi F  Gandini G  Diana A  Preziosi R  Ingh TS  Famigli-Bergamini P  Kooistra HS 《Domestic animal endocrinology》2007,32(1):43-54

A 10-year-old uncastrated male Dalmatian dog was referred for gait abnormalities consisting of chronic progressive stiffness and rigidity. Other symptoms were polyphagia associated with weight gain, polyuria and polydipsia, excessive panting, and an inspiratory stridor. The owner had noticed progressive thickening of the skin and enlargement of the tongue over the last 3 years. Physical examination revealed thickening of the skin, redundant skin folds, and enlargement of the tongue. The only remarkable abnormalities found on routine laboratory examination were mild anaemia and an increased serum fructosamine concentration. Circulating concentrations of total thyroxine, free thyroxine, and cTSH, and the results of an ACTH stimulation test were all within reference ranges. The basal serum growth hormone (GH) concentration was markedly elevated (23microg/l) and did not decrease during a glucose tolerance test or after somatostatin administration. The serum insulin-like growth factor-1 concentration was also markedly elevated (1254microg/l). Basal serum insulin concentration was high (95mU/l) and insulin concentrations increased considerably after glucose loading, consistent with insulin resistance. Abdominal ultrasonography showed no abnormalities. Survey radiographs of the vertebral column showed severe spondylosis deformans extending from the cervical to the lumbosacral spine. CT scanning of the skull showed an enlarged pituitary gland with normal enhancement pattern. On post-mortem examination, the entire vertebral column appeared as a single and inflexible structure due to the presence of multiple fused osteophytes. The pituitary gland contained an acidophilic adenoma that immunostained positively for GH (and negatively for ACTH and alpha-MSH). In conclusion, this Dalmatian dog with acromegaly and insulin resistance represents the first case of GH hypersecretion proven to be due to a somatotroph adenoma.  相似文献   

Quercus suber and Betula pendula outer barks as renewable sources of oleochemicals: A comparative study     

Paula C.R.O. Pinto  Andreia F. Sousa  Armando J.D. Silvestre  Carlos Pascoal Neto  Alessandro Gandini  Christer Eckerman  Bjarne Holmbom 《Industrial Crops and Products》2009,29(1):126-132

A comparative study on the chemical composition of oak cork (Quercus suber L.) and corresponding industrial residues and birch (Betula pendula L.) outer bark is reported. Cork oak samples have lower extractives contents (6–9%) and higher contents of carbohydrates and lignin (23–27 and 33–38%, respectively) than those found for birch outer bark (40, 6 and 9%, respectively); suberin contents accounted for around 30% of cork, 11% of industrial cork powder and 45% of birch outer bark. Analysis of the suberin monomeric composition revealed that C18 and C22 ω-hydroxyfatty acids (including mid-chain epoxy- and dihydroxy-derivatives), followed by α,ω-dicarboxylic acids, are the main components in both suberins, with 9,10-epoxy-18-hydroxyoctadecanoic, 18-hydroxyoctadec-9-enoic, 9,10,18-trihydroxyoctadecanoic and octadec-9-enoic acids as the major components. The differences in the relative amounts of these acids in the suberin samples and the impact on the potential exploitation of the different industrial by-products are discussed.  相似文献   

In vitro evaluation of a closed-bowel technique for one-layer hand-sewn inverting end-to-end jejunojejunosotomy in the horse     

Gandini M 《Veterinary surgery : VS》2006,35(7):683-688

OBJECTIVE: To report a technique for closed-bowel 1-layer inverting end-to-end jejunojejunal anastomosis in horses. STUDY DESIGN: Experimental study. SAMPLE POPULATION: Fresh cadaveric jejunal segments from 12 horses. METHODS: For each bowel segment a 1-layer closed and a 2-layer inverting end-to-end jejunojejunosotomy was created. Anastomosis construction time and anastomotic bursting pressure were measured and compared. RESULTS: Closed-bowel anastomosis was significantly faster to create than a 2-layer technique. Luminal narrowing (<30%) was similar with both techniques and comparable with other inverting techniques. Bursting pressure was significantly higher for the 2-layer technique, although all anastomoses resisted pressures higher than those reported for other jejunojejunal anastomosis techniques. CONCLUSIONS: A 1-layer hand-sewn, closed, inverting jejunojejunosotomy using a modified Doyen clamp was easy and faster to perform, and resulted in functional characteristics similar to, a 2-layer hand-sewn inverting technique. CLINICAL RELEVANCE: A closed, 1-layer inverting technique could be considered for equine jejunal anastomosis but requires in vivo evaluation before recommendation for clinical use.  相似文献   

Immunohistochemical profiling and telomerase activity of a canine medulloblastoma     

Mandrioli L  Biserni R  Panarese S  Morini M  Gandini G  Bettini G 《Veterinary pathology》2011,48(4):814-816

A well-demarcated mass was found by computed tomography in the left cerebellar hemisphere of a 4-year-old male Boxer with acute onset of progressive central vestibular syndrome. At necropsy, the pink, gelatinous mass was in the flocculonodular lobe. Histologically, neoplastic tissue arose from the granular layer of the cerebellar cortex and consisted of sheets of oval to round hyperchromatic cells, consistent with the diagnosis of medulloblastoma. Synaptophysin and neuron-specific enolase immunoreactivity supported the neuronal origin of the neoplastic cells; furthermore, a weak to moderate c-kit expression was detected, as reported in pediatric medulloblastoma. Telomerase activity of tumor cells was demonstrated by immunohistochemistry and by the telomere repeat amplification protocol, suggesting involvement of this enzymatic pathway.  相似文献   

Management of Chronic Diarrhea in an Adult Horse     

Emanuela Valle  Marco Gandini  Domenico Bergero 《Journal of Equine Veterinary Science》2013

Chronic diarrhea could be a challenge from both the diagnostic and therapeutic point of view. This case report will discuss the clinical approach to the evaluation of chronic diarrhea with the production of free fecal water in an adult horse. The discussion of this case report may provide further information and describe a possible therapeutic option with sulfasalzine, focusing on the nutritional management of chronic diarrhea in adult horses. Nutritional management could be of higher importance for horses that suffer from this problem because it improves the well-being of the hindgut environment. In the present case report, motility abnormalities were identified without other physiological disturbances of colonic function or a decrease in body weight, and the priority was the following: (1) rebalancing of the diet to the real nutritional requirements of the patient, (2) avoiding excess carbohydrate from both forage and concentrate, (3) selecting the right proportion between good quality first-cut meadow hay and grounded and pelleted meadow hay that helps to reduce mechanical and physical load of the colon and could help in the formation of more homogeneous digesta, (4) reducing the stress with adequate feed consumption time, meal size, and time spent in a overgrazed paddock, and (5) increasing the proportion of omega-3 fatty acids in the diet. With the nutritional plan and management and the initial use of sulfasalazine, the horse maintained a good quality of the feces with a reduced or absent production of the free fecal water.  相似文献   

Astaxanthin Improves Human Sperm Capacitation by Inducing Lyn Displacement and Activation     

Alessandra Andrisani  Gabriella Donà  Elena Tibaldi  Anna Maria Brunati  Chiara Sabbadin  Decio Armanini  Gualtiero Alvisi  Salvatore Gizzo  Guido Ambrosini  Eugenio Ragazzi  Luciana Bordin 《Marine drugs》2015,13(9):5533-5551

Astaxanthin (Asta), a photo-protective red pigment of the carotenoid family, is known for its multiple beneficial properties. In this study, the effects of Asta on isolated human sperm were evaluated. Capacitation involves a series of transformations to let sperm acquire the correct features for potential oocyte fertilization, including the generation of a controlled amount of reactive oxygen species (ROS), cholesterol depletion of the sperm outer membrane, and protein tyrosine phosphorylation (Tyr-P) process in the head region. Volunteers, with normal spermiogram values, were divided in two separate groups on the basis of their ability to generate the correct content of endogenous ROS. Both patient group (PG) and control group (CG) were analysed for Tyr-phosphorylation (Tyr-P) pattern and percentages of acrosome-reacted cells (ARC) and non-viable cells (NVC), in the presence or absence of Asta. In addition, the involvement of ROS on membrane reorganization and the presence of Lyn, a Src family kinase associated with lipid rafts, were investigated. Results show that Lyn is present in the membranes of human sperm, mainly confined in midpiece in resting conditions. Following capacitation, Lyn translocated to the head concomitantly with raft relocation, thus allowing the Tyr-P of head proteins. Asta succeeded to trigger Lyn translocation in PG sperm thus bypassing the impaired ROS-related mechanism for rafts and Lyn translocation. In this study, we showed an interdependence between ROS generation and lipid rafts and Lyn relocation leading the cells to undergo the successive acrosome reaction (AR). Asta, by ameliorating PG sperm functioning, may be utilised to decrease male idiopathic infertility.  相似文献   

Acquisition of Involuntary Spinal Locomotion (Spinal Walking) in Dogs with Irreversible Thoracolumbar Spinal Cord Lesion: 81 Dogs          下载免费PDF全文

A. Gallucci  L. Dragone  M. Menchetti  T. Gagliardo  M. Pietra  M. Cardinali  G. Gandini 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2017,31(2):492-497

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