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ENERGY EVALUATION OF POULTRY FEEDSTUFFS 总被引:1,自引:0,他引:1
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Sharma AK Kumar N Dimri U Hoque M Maiti SK Gupta OP Shahi A 《Journal of veterinary medicine. A, Physiology, pathology, clinical medicine》2004,51(9-10):420-424
The study was conducted on 10 buffalo calves with a weight of 98.5 +/- 3.9 kg and age 9.7 +/- 1.3 months. Ten trials of two treatments were carried out using a randomized block design. Atropine at the dose of 0.02 mg/kg bodyweight was administered in both the groups. The animals of group I received romifidine at the dose of 10 microg/kg i.v., 10 min after atropine administration, whereas, animals of group II received triflupromazine at the dose of 0.3 mg/kg i.m. and 10 min later romifidine at the dose of 10 microg/kg i.v. immediately followed by ketamine at the dose of 5 mg/kg i.v. The onset of action of romifidine in group I occurred within 2 min and the animals remained under mild sedation for 31 +/- 4.8 min. In group II, the triflupromazine-romifidine-ketamine combination induced anaesthesia for 14 +/- 2.3 min. Hypothermia, significant bradycardia and respiratory depression was noticed in both groups at different time intervals. 相似文献
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Association mapping was undertaken in common wheat to identify markers associated with pre-harvest sprouting tolerance (PHST). For this purpose, a population of 242 wheat genotypes and 250 SSR markers were used. The population used consisted of diverse germplasm, which carried sufficient phenotypic variation for PHS for conducting association mapping. The population was found to be structured and stratified into 15 sub-populations; the tolerant and moderately tolerant wheat genotypes were distributed in all the sub-populations. This feature of the population along with other information on population structure was used in association mapping using both the available models, the general linear model (GLM) and the mixed linear model (MLM); hopefully, this minimized the rate of false positives. As many as 30 markers were found to be associated with PHST, 26 markers with GLM and 17 markers with MLM; 13 markers were detected using both the approaches. Only eight SSR markers associated with QTL for PHST were such, which were located within the marker intervals that were earlier reported to carry QTLs for PHST. The remaining 22 markers that were found to be associated with PHST could not be associated with any of the genomic regions known to carry QTLs for PHST, which are known to occur on all the 42 chromosome arms of wheat genome. 相似文献
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Gupta S Khanna VK Maurya A Bawankule DU Shukla RK Pal A Srivastava SK 《Fitoterapia》2012,83(6):1092-1099
This study was undertaken to ascertain the antipsychotic properties of Rauwolfia tetraphylla L. leaves and to isolate and characterize the antipsychotic constituents. Among the MeOH extract and some alkaloidal fractions at different pHs, the alkaloidal CHCl(3) fraction at pH-9 (2C) showed the highest antipsychotic activity against dopaminergic (DA-D(2)) and serotonergic (5-HT(2A)) receptors in-vitro and amphetamine induced hyperactive mouse model in-vivo. The activity guided isolation of CHCl(3) fraction (2C) afforded six indole alkaloids: 10-methoxytetrahydroalstonine (1), isoreserpiline (2), an isomeric mixture of 11-demethoxyreserpiline (3) and 10-demethoxyreserpiline (4), α-yohimbine (5) and reserpiline (6). Given orally, alkaloids 3-6 showed significant antipsychotic activity in a dose dependent manner. None of the extract, alkaloidal fractions or alkaloids showed any extra pyramidal symptoms at the tested doses. It was also observed that MeOH extract was behaving similar to other clinically used novel atypical antipsychotics in having 5-HT(2A) occupancy greater than the DA-D(2) receptor at the tested doses. Further toxicity and safety evaluation studies of MeOH extracts of R. tetraphylla leaves at different doses (10, 100, 300 and 2000 mg/kg) on female Swiss albino mice showed that MeOH extract is non toxic. The isolated alkaloids, 3-6 could serve as a promising lead structure for drug development of treating psychotic conditions in human. 相似文献
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Gupta RC Canerdy TD Lindley J Konemann M Minniear J Carroll BA Hendrick C Goad JT Rohde K Doss R Bagchi M Bagchi D 《Journal of animal physiology and animal nutrition》2012,96(5):770-777
The investigation was conducted on client-owned moderately arthritic dogs with two objectives: (i) to evaluate therapeutic efficacy of type-II collagen (UC-II) alone or in combination with glucosamine hydrochloride (GLU) and chondroitin sulphate (CHO), and (ii) to determine their tolerability and safety. Dogs in four groups (n = 7-10), were treated daily for a period of 150 days with placebo (Group-I), 10 mg active UC-II (Group-II), 2000 mg GLU + 1600 mg CHO (Group-III), and UC-II + GLU + CHO (Group-IV). On a monthly basis, dogs were evaluated for observational pain (overall pain, pain upon limb manipulation, and pain after physical exertion) using different numeric scales. Pain level was also measured objectively using piezoelectric sensor-based GFP for peak vertical force and impulse area. Dogs were also examined every month for physical, hepatic (ALP, ALT and bilirubin) and renal (BUN and creatinine) functions. Based on observations, significant (p < 0.05) reduction in pain was noted in Group-II, III, and IV dogs. Using GFP, significant increases in peak vertical force (N/kg body wt) and impulse area (N s/kg body wt), indicative of a decrease in arthritis associated pain, were observed in Group-II dogs only. None of the dogs in any group showed changes in physical, hepatic or renal functions. In conclusion, based on GFP data, moderately arthritic dogs treated with UC-II (10 mg) showed a marked reduction in arthritic pain with maximum improvement by day 150. UC-II, GLU and CHO operate through different mechanisms of action, and were well tolerated over a period of 150 days. 相似文献