Measurement of respiratory system compliance and respiratory system resistance in healthy dogs undergoing general anaesthesia for elective orthopaedic procedures     

Carl A Bradbrook  Louise Clark  Alexandra HA Dugdale  John Burford  Martina Mosing 《Veterinary anaesthesia and analgesia》2013,40(4):382-389

Objective The aim of this study was to investigate normal values for the dynamic compliance of the respiratory system (Crs) and respiratory system resistance (Rrs) in mechanically ventilated anaesthetized dogs.Study design Prospective clinical study.Animals Forty healthy dogs undergoing elective orthopaedic surgery. Body weight was (mean ± SD) 26.8 ± 10.7 kg (range: 1.9–45.0 kg), age 4.7 ± 2.9 years (range: 0.1–10.6 years).Methods Dogs were premedicated with acepromazine and methadone administered intramuscularly and anaesthesia induced with propofol intravenously. After endotracheal intubation the dog's lungs were connected to an appropriate breathing system depending on body weight and isoflurane in oxygen administered for maintenance of anaesthesia. The lungs were ventilated mechanically with variables set to maintain normocapnia (end‐tidal carbon dioxide concentration 4.7–6.0 kPa). Peak inspiratory pressure, Crs, Rrs, tidal volume, respiratory rate and positive end‐expiratory pressure were recorded at 5, 30, 60, 90 and 120 minutes after start of mechanical ventilation. Cardiovascular variables were recorded at time of collection of respiratory data.Results General additive modeling revealed the following relationships: Crs = [0.895 × body weight (kg)] + 8.845 and Rrs = [?0.0966 × body weight (kg)] + 6.965. Body weight and endotracheal tube diameter were associated with Crs (p <0.001 and p =0.002 respectively) and Rrs (p = 0.017 and p =0.002 respectively), body weight being linearly related to Crs and inversely to Rrs.Conclusion and clinical relevance Body weight was linearly related to Crs while Rrs has an inverse linear relationship with body weight in mechanically ventilated dogs. The derived values of Crs and Rrs may be used for monitoring of lung function and ventilation in healthy dogs under anaesthesia.  相似文献   

辐照对黄原胶分子量、结构及流变性能的影响     

李彦杰  哈益明  王锋  李咏富 《中国农业科学》2011,44(21):4454-4463

 【目的】探讨辐照剂量对黄原胶分子量、分子量分布、结构、流变性能的影响,为辐照技术在黄原胶及其它多糖分子修饰上的应用提供理论依据。【方法】以60Co-γ射线对固态黄原胶进行不同剂量 (0—400 kGy) 的辐照,采用凝胶渗透色谱（GPC）、X-射线衍射(XRD)、红外扫描(FTIR)、紫外-可见光扫描(UV-vis)以及流变仪等对样品的分子量、分子量分布、结构以及流变性能进行表征和测定。【结果】低于10 kGy剂量的辐照使黄原胶分子量增大,分子量分布变窄;辐照剂量高于10 kGy后,分子量随剂量增大而降低,而分子量分布先变宽,在50 kGy时达到最大后,又趋于变窄。X-射线衍射、红外及紫外分析表明,辐照造成黄原胶分子上的部分糖苷键发生断裂,引起结晶度的变化,并在链端产生少量羰基,但其基本化学结构和晶体结构保持稳定。辐照处理后,黄原胶溶液的表观黏度与剪切速率、剪切时间和温度之间的关系均发生了显著变化。【结论】γ射线可同时作用于黄原胶的结晶区和无定形区,引发聚合和降解两种辐照效应,并对其分子量、分子量分布造成显著影响,进而使其流变性能发生改变。  相似文献   

不同育苗措施对烟苗素质的影响   总被引：5，自引：1，他引：4  

王勇  哈长江  姜思永  李觅  李伟  荣凡番  郭永新  刘德育  赵光伟 《江西农业学报》2011,23(8):88-89,92

研究了烤烟阳光板大棚育苗的播种期与增温措施组合对烟苗素质的影响,结果表明,3月20日为富锦烟区最适宜的播芽种期,并于4月11日(小十字期)假植,采用离地床、地上铺砖坑作保温层(20 cm)、上垫5 cm表土的育苗措施。移栽前烟苗素质表现为苗床期60 d,茎高10.5 cm,茎粗0.61 cm,真叶数9.2,单株鲜重7.78 g,单株干重0.38 g。  相似文献   

Pharmacokinetics of Idazoxan in Deers Following Intramuscular Administration     

YIN Baishuang  GAO Li  WANG Hongbin  HA Da 《东北农业大学学报(英文版)》2011,18(3):28-32

The aim of this experiment was to determine the pharmacokinetics of hydrochloric idazoxan in deers plasma alter intramuscular （IM） dosing. Six clinical healthy Cervus nippon Temmincks were injected with the idazoxan solution at the dose of 0.44 mg·kg-1. Eight mL blood sample was taken from a jugular vein and plasma was separated for drug determination by using liquid chromatography with tandem mass spectrometric detection. Idazoxan pharmacokinetic parameters were simulated by noncompartmental analyses. The results showed that the absorption and elimination of hydrochloric idazoxan in plasma was quick by route of administration, the half-lives of absorption （t1/2Ka） and elimination （t1/2Kc） were （0.2094 ± 0.0341） min, and （13.1842±0.2353） min, respectively, the area under the plasma drug concentration-time curve from 0 to ∞ （AUC） was （0.0700±0.0035） （mg·mL-1）. min the maximum concentration in the plasma （Cmax） was （0,0047±0.0005） mg.mL ＇, peaking at （12.4618±0.1198） rain after dosing. In conclusion, these data indicated that the kinetics of hydrochloric idazoxan were fitted to one compartment model with first order absorption, which was characterized by rapid drug action, and fast metabolism with few residue in the blood.  相似文献   

辐照控制菲律宾蛤仔中治病菌及其在贮藏期的生长情况     

居华  王锋  哈益明  刘书亮 《核农学报》2009,23(1):102-105

研究了菲律宾蛤仔经60Coγ射线辐照后,其中的菌落总数、大肠肝菌和副溶血性的D₁₀值及辐照后在贮藏期的变化。结果表明,经60Coγ射线辐照后菲律宾蛤仔中的菌落总数、大肠肝菌、副溶血性的D₁₀值分别为：0.70、0.56和0.20kGy;真空包装的菲律宾蛤仔在0°C~4°C贮藏条件下,3kGy剂量辐照贮藏28d后菌落总数为4.46log(CFU/g),符合水产品卫生要求;而0.4kGy剂量辐照贮藏7d后大厂肝菌、副溶血性弧菌后检测未检出。由此可见,3kGy以上剂量辐照处理菲律宾蛤仔,能有效杀灭其中的微生物,且其贮藏期可达28d,用辐照方法保鲜菲律宾蛤仔具有一定实际意义。  相似文献   

基于6-BA／NAA的黑树莓不定芽再生的研究     

哈玲津  马颖  杨静慧 《天津农学院学报》2009,16(2):15-16,30

为了快速繁殖优良种黑树莓,进行了不同激素、不同外植体的组织培养和再生研究。结果显示：在不同6．BA浓度培养下,均为茎段的不定芽的再生率最高,叶柄次之,叶片最低。并且,随着培养基6．BA浓度的增加,各外植体的芽分化率具有相同的变化趋势,均呈抛物线型变化。各外植体均在4．0mg．L～6-BA和0．1mg．L-1 NAA时芽的分化率最高,其中黑树莓茎段的不定芽的再生率高达87．50％。  相似文献   

不同大豆品种种子萌芽期的耐盐性   总被引：7，自引：0，他引：7  

刘太林  杨静慧  穆俊丽  张伟玉  哈玲津  桂毓  朱文碧  杜长城  陈月 《大豆科学》2009,28(5)

对10个栽培品种大豆种子进行不同盐浓度处理(3、6、9、12、15、18 g·L-1)后,统计了种子的发芽率、相对发芽率、发芽势、相对胚根长度,分析了其耐盐浓度、耐盐半致死浓度、耐盐极限浓度和各指标隶属函数,综合评价了各品种的耐盐性.随着盐浓度的增加,品种问的发芽势、发芽率和胚根长度都呈下降趋势,品种间存在显著差异.当NaCl浓度增加到9 g·L-1时,各品种的发芽率、发芽势差异最大.在12 g·L-1的盐浓度下品种间相对胚根长度差异最大.各品种中耐盐浓度最高的为绥农10(可耐12 g·L-1的盐),其次为抗线4和飞龙1(可耐9 g·L-1的盐).耐盐半致死浓度最大的品种为绥农10.耐盐极限浓度最高的也是绥农10.综合分析各指标抗盐隶属值,各大豆品种的耐盐性强弱顺序依次为:绥农10＞抗线4＞丰豆1＞龙选1＞合丰55＞飞龙1＞垦丰16＞绥农14＞黑农48＞黑农44.  相似文献   

丙烯酸松香与乙二醇二缩水甘油醚预聚体的合成和性能研究   总被引：1，自引：0，他引：1  

马一静  沈敏敏  李因文  哈成勇 《林产化学与工业》2009,29(6):57-60

丙烯酸松香与乙二醇二缩水甘油醚酯化合成环氧树脂预聚体.探讨了反应温度、催化剂用量等因素对反应的影响,得到最优条件为三乙胺用量0.02%(以丙烯酸松香质量计),反应温度130℃,反应时间5h.预聚体的环氧值0.19mol/100g,黏度16.3Pa · s(36℃),酸值0.4mg/g.采用差示扫描量热分析(DSC)、FT - IR等方法研究了固化物性能.结果表明,甲基六氢苯酐(MeHHPA)为固化剂,当m(MeHHPA): m(预聚体)8: 10,固化条件为:预聚100℃,反应2h,190℃固化5h,固化物的玻璃化转变温度(T_g)最高(53.0℃).  相似文献   

超临界 CO2 萃取落叶松木材挥发油的工艺研究   总被引：1，自引：0，他引：1  

金建忠  哈成勇 《林产化学与工业》2009,29(5)

采用超临界CO2萃取技术萃取落叶松木材挥发油,以得率为考察指标,研究了萃取压力、萃取温度、CO2流量和萃取时间对得率的影响.确定了超临界CO2萃取落叶松木材挥发油的最佳工艺参数:萃取压力35MPa,萃取温度60℃,CO2流量10kg/h,萃取时间2h,在此条件下挥发油得率可达0.57%.  相似文献   

Toll‐like receptor and related cytokine mRNA expression in bovine corpora lutea during the oestrous cycle and pregnancy          下载免费PDF全文

JE Gadsby  AM Tyson Nipper  HA Faircloth  M D'Annibale‐Tolhurst  J Chang  PW Farin  IM Sheldon  DH Poole 《Reproduction in domestic animals》2017,52(3):495-504

Improving our understanding of the mechanisms controlling the corpus luteum (CL) and its role in regulating the reproductive cycle should lead to improvements in the sustainability of today's global animal industry. The corpus luteum (CL) is a transient endocrine organ composed of a heterogeneous mixture steroidogenic, endothelial and immune cells, and it is becoming clear that immune mechanisms play a key role in CL regulation especially in luteolysis. Toll‐like receptors (TLR) mediate innate immune mechanisms via the production of pro‐inflammatory cytokines, especially within various tissues, although the role of TLR within CL remains unknown. Thus, the objectives of this study were to characterize TLR mRNA expression in the CL during the oestrous cycle and in pregnancy (day 30–50), and to examine the role of TLR signalling in luteal cells. Corpora lutea were collected at various stages of the cycle and pregnancy and analysed for TLR and cytokine mRNA expression. In addition, luteal cells were cultured with the TLR4 ligand (lipopolysaccharide, LPS) for 24 h to evaluate the role of TLR4 in regulating luteal function. Toll‐like receptors 1, 2, 4, 6, tumour necrosis factor alpha (TNF), interferon gamma (IFN‐G), and interleukin (IL)‐12, mRNA expressions were greatest in regressing CL compared with earlier stages (p < .05), whereas no change was observed for IL‐6 mRNA expression. Cytokine mRNA expression in cultured luteal cells was not altered by LPS. Based on these data, one or more of the TLRs found within the CL may play a role in luteolysis, perhaps via pro‐inflammatory cytokine mRNA expression.  相似文献