The Impact of Demographic,Social, and Environmental Factors on the Development of Steroid‐Responsive Meningitis‐Arteritis (SRMA) in the United Kingdom     

J.H. Rose  M. Kwiatkowska  E.R. Henderson  N. Granger  J.K. Murray  T.R. Harcourt‐Brown 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(4):1199-1202

Background

Steroid‐responsive meningitis‐arteritis (SRMA) is an inflammatory disease of dogs that is suspected to be immune‐mediated. The development of other immune‐mediated diseases has been linked to vaccinations, time of the year, geographic location, sex, neuter status, and breed.

Hypothesis/Objectives

To identify if the development of SRMA is associated with time of year, vaccination, geographic location, sex, neuter status, and breed.

Animals

Sixty SRMA cases and 180 controls, all ≤24 months of age and matched for year of presentation, from a referral hospital population in the United Kingdom.

Methods

Retrospective case‐control study with unconditional logistic regression analysis.

Results

Beagles (P = .001), Border Collies (P = .001), Boxers (P = .032), Jack Russell Terriers (P = .001), Weimaraners (P = .048), and Whippets (P < .001) had significantly greater odds of developing SRMA in this population of dogs. Vaccination, time of year, geographic category, sex, and neuter status did not increase the odds of developing SRMA.

Conclusions and Clinical Importance

Only breed increased the odds of developing SRMA. It would be prudent to investigate the genetics of the identified breeds to help elucidate the etiopathogenesis of SRMA.  相似文献   

Voluntary Stewardship and the Canadian Species at Risk Act: Exploring Rancher Willingness to Support Species at Risk in the Canadian Prairies     

Allison E. Henderson  Maureen Reed  Stephen K. Davis 《Human Dimensions of Wildlife》2014,19(1):17-32

North American temperate grasslands and the wildlife species they support are increasingly imperilled, largely due to habitat loss and degradation. Most remaining prairie is privately managed and supports livestock production. In Canada, voluntary stewardship is the preferred approach for protecting species at risk on private lands under the federal Species at Risk Act (SARA). However, attitudes of private land managers toward species at risk and their willingness to engage in stewardship are poorly understood. With data from interviews with 42 livestock producers in Saskatchewan, Canada, we describe producer characteristics, attitudes, and awareness of species at risk and evaluate how these factors influence willingness to protect species at risk. Younger producers with increased formal education, awareness, and positive attitudes were more willing to support conservation of species at risk. Voluntary stewardship under the SARA may be enhanced by rewarding producers for sound habitat management and improving trust between producers and government agencies.  相似文献   

Impact of a Student-Organized Conference on Wilderness Medicine Education     

Stephanie A. Lareau  Patrick E. Robinson  Sean S. Wentworth  Henderson D. McGinnis 《The Forestry Chronicle》2014,25(1):120-121

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RESUSCITATION WITH CARBON DIOXIDE     

Henderson Y 《Science (New York, N.Y.)》1936,83(2157):399-402

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Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter     

Weyand S  Shimamura T  Yajima S  Suzuki S  Mirza O  Krusong K  Carpenter EP  Rutherford NG  Hadden JM  O'Reilly J  Ma P  Saidijam M  Patching SG  Hope RJ  Norbertczak HT  Roach PC  Iwata S  Henderson PJ  Cameron AD 《Science (New York, N.Y.)》2008,322(5902):709-713

The nucleobase-cation-symport-1 (NCS1) transporters are essential components of salvage pathways for nucleobases and related metabolites. Here, we report the 2.85-angstrom resolution structure of the NCS1 benzyl-hydantoin transporter, Mhp1, from Microbacterium liquefaciens. Mhp1 contains 12 transmembrane helices, 10 of which are arranged in two inverted repeats of five helices. The structures of the outward-facing open and substrate-bound occluded conformations were solved, showing how the outward-facing cavity closes upon binding of substrate. Comparisons with the leucine transporter LeuT(Aa) and the galactose transporter vSGLT reveal that the outward- and inward-facing cavities are symmetrically arranged on opposite sides of the membrane. The reciprocal opening and closing of these cavities is synchronized by the inverted repeat helices 3 and 8, providing the structural basis of the alternating access model for membrane transport.  相似文献   

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes     

O'Doherty A  Ruf S  Mulligan C  Hildreth V  Errington ML  Cooke S  Sesay A  Modino S  Vanes L  Hernandez D  Linehan JM  Sharpe PT  Brandner S  Bliss TV  Henderson DJ  Nizetic D  Tybulewicz VL  Fisher EM 《Science (New York, N.Y.)》2005,309(5743):2033-2037

Aneuploidies are common chromosomal defects that result in growth and developmental deficits and high levels of lethality in humans. To gain insight into the biology of aneuploidies, we manipulated mouse embryonic stem cells and generated a trans-species aneuploid mouse line that stably transmits a freely segregating, almost complete human chromosome 21 (Hsa21). This "transchromosomic" mouse line, Tc1, is a model of trisomy 21, which manifests as Down syndrome (DS) in humans, and has phenotypic alterations in behavior, synaptic plasticity, cerebellar neuronal number, heart development, and mandible size that relate to human DS. Transchromosomic mouse lines such as Tc1 may represent useful genetic tools for dissecting other human aneuploidies.  相似文献   

Industrial air pollution: possible effect on lung cancer   总被引：2，自引：0，他引：2  

H R Menck  J T Casagrande  B E Henderson 《Science (New York, N.Y.)》1974,183(4121):210-212

Higher lung cancer mortality rates occurred in males living in certain heavily industrialized areas of Los Angeles County, California. These areas were characterized by elevated concentrations of benzo[a]pyrene and other polynuclear aromatic hydrocarbons of primarily industrial origin in the soil and air.  相似文献   

Mortality of salmonids cultured at low temperature in sea water     

Richard L. Saunders  Brian C. Muise  Eugene B. Henderson 《Aquaculture (Amsterdam, Netherlands)》1975,5(3):243-252

Brook trout, rainbow trout, and Atlantic salmon were acclimated to sea water (30‰ S) and placed during autumn in floating cages in a concrete tide pool. The salmon (mean length ca 26 cm in mid-October) grew about 2 cm before they stopped feeding in December. The brook trout (19 cm) and rainbow trout (21 cm) grew little, if any, during December. Feeding by the rainbow trout and salmon continued until temperature fell below 1°C. The brook trout fed little, if any, during December while temperature fell from 4 to 1°C. Brook trout, particularly the mature individuals, had high mortality rates from the time they were put into sea water. Blood plasma osmolalities indicated that brook trout, but not the other species, were under severe osmotic stress in sea water. Most of the fish (all three species) died in a 4-day period during early January when the water cooled to ?0.7 to ?0.8°C. A temperature of ?0.7°C is a reasonable approximation of the lower lethal temperature for these salmonids at 30‰ salinity. Based on our observations, it is not practicable to hold the above species in sea water which is likely to get colder than 1°C because of poor growth and the risk of mortality.  相似文献   

Partial decontamination of rotifers with ultraviolet radiation: the effect of changes in the bacterial load and flora of rotifers on mortalities in start-feeding larval turbot     

P. D. Munro  R. J. Henderson  A. Barbour  T. H. Birkbeck   《Aquaculture (Amsterdam, Netherlands)》1999,170(3-4):229-244

Exposure of the rotifer Brachionus plicatilis to ultraviolet radiation in 1 mm deep liquid layers at an energy intensity of 38 mW cm⁻² reduced the rotifer bacterial load by >90% within 2 min. Such radiation doses had no significant effect upon rotifer viability, fatty acid composition, swimming or feeding activity. The surviving bacterial flora of irradiated rotifers was similar to that of un-irradiated rotifers and there was no evidence of major differences in sensitivity to ultraviolet radiation between different bacteria. For irradiation of large numbers of rotifers, a flow-through cell was used, operated with rotifer densities of 200 ml⁻¹ and a flow rate of 1.5 l min⁻¹. In two separate field trials involving groups of 34,000 turbot larvae per group, higher survival was found in groups receiving ultraviolet-irradiated rotifers in which the bacterial load was reduced by 88%. This was attributed to the slower rate of colonisation of the larval gut by bacteria, as a consequence of the lower bacterial load on the rotifers. Attempts to introduce specified bacteria into the larval turbot gut in significant numbers by colonisation of either normal or irradiated rotifers with particular bacteria were unsuccessful.  相似文献