Deficiency of bile salts causing steatorrhoea and weight loss in two dogs     

J. W. Simpson  A. van den  Broek 《The Journal of small animal practice》1989,30(10):567-569

Two dogs were presented with chronic diarrhoea, weight loss and skin problems. In each case investigation revealed persistent steatorrhoea due to a failure in fat digestion and absorption which was associated with a bile salt deficiency. Replacement therapy resulted in a significant improvement in the condition of each dog.  相似文献   

Hexachlorophene-pHisohex toxicity in pups     

G T Edds  C F Simpson 《American journal of veterinary research》1974,35(7):1005-1007

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Protection of cattle against heartwater in Botswana: comparative efficacy of different methods against natural and blood-derived challenges     

B C Simpson  M S Lindsay  J R Morris  F S Muirhead  A Pollock  S G Prichard  H G Stanley  G R Thirlwell  A G Hunter  J Bradley 《The Veterinary record》1987,120(6):135-138

Five groups of Tswana-cross castrated male cattle between 20 and 30 months of age (a total of 158 animals) were transported from a ranch in a heartwater-free area of south Botswana to a feedlot near Gaborone in the east of Botswana where heartwater is endemic. On arrival, one group was vaccinated intravenously with the Onderstepoort sheep blood heartwater vaccine, one group was vaccinated intravenously with the new Onderstepoort tick-derived heartwater vaccine and a third group was vaccinated subcutaneously with this tick-derived vaccine. Vaccine reactions were blocked with long acting oxytetracycline on the first day of fever. A fourth group had a series of injections of long acting oxytetracycline on days 0, 7, 14 and 21 after arrival, and a fifth served as untreated controls. The animals remained at the feedlot for 65 days during which time they faced a low level of challenge by Amblyomma hebraeum ticks. None contracted heartwater and so they were then challenged, together with a further group of control cattle, with a dose of the sheep blood vaccine. Some animals in all groups had severe heartwater reactions and died despite therapy, but 76.7 per cent, 64.5 per cent and 74.3 per cent of the cattle in the blood vaccine, intravenous tick vaccine and long acting oxytetracycline groups respectively were resistant to challenge, compared with 48.3 per cent of the subcutaneous tick vaccine group and 36.4 per cent of the controls. It was concluded that intravenous vaccination of susceptible adult cattle with either the blood or the tick-derived vaccine needs careful monitoring in the month after vaccination and does not necessarily result in immune animals.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

The excretion of campylobacter,salmonellae andGiardia lamblia in the faeces of stray dogs     

A. G. Burnie  J. W. Simpson  D. Lindsay  R. S. Miles 《Veterinary research communications》1983,6(1):133-138

Faecal samples were collected from impounded stray dogs, classified as under or over six months of age, on their arrival in kennels and again 5–7 days later. The faeces were examined for the presence of campylobacters, salmonella andGiardia lamblia. No significant difference was found in the rate of isolation of these organisms between the two age groups. There was, however, a significant increase in the rate of isolation at days 5–7 compared with day 1. It is suggested that while dogs may acquire campylobacter infection in kennels, excretion of the organism may be intermittent and may be precipitated by stress. A low incidence of salmonellae andGiardia lamblia excretion was detected.  相似文献   

Determination of dithiocarbamates in carbonate-based formulations of maneb and zineb     

B. W. Simpson 《Pest management science》1971,2(3):127-128

A method is described for the determination of dithiocarbamates in maneb and zineb formulations containing carbonates. Carbon disulphide evolved during acid hydrolysis is trapped in methanol and measured directly by absorption at V_max 3140mm^?1.  相似文献   

Diagnostic value of exfoliative cytology of body fluids in dogs and cats     

R W Else  J W Simpson 《The Veterinary record》1988,123(3):70-76

A method for collecting body fluids for cytological examination and their subsequent preparation and staining is described. The results of the cytological examination of 80 dogs and 26 cats over a period of three years are reported, indicating the number and types of condition which can be diagnosed, together with the clinicopathological correlations.  相似文献   

Ages of experimental animals     

Simpson GG 《Science (New York, N.Y.)》1966,151(3710):517

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Solanum torvum as a causative agent of enzootic calcinosis in Papua, New Guinea     

K M Morris  J P Simonite  L Pullen  J A Simpson 《Research in veterinary science》1979,27(2):264-266

Inclusion of dried powdered leaves of Solanum torvum Swartz (collected in Papua, New Guinea) in the diet of rats induced hypercalcaemai rapidly and hyperphosphataemia more slowly; soft tissue calcification was most evident in the kidney and lung. Solanum torvum may be a causative agent of enzootic calcinosis in cattle in Papua, New Guinea.  相似文献   

Letters to the Editor     

Simpson GG 《Science (New York, N.Y.)》1960,131(3416):1817-1818

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Somatostatin receptor imaging in vivo by planar scintigraphy facilitates the diagnosis of canine insulinomas     

Garden OA  Reubi JC  Dykes NL  Yeager AE  McDonough SP  Simpson KW 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(2):168-176

Somatostatin receptors expressed by insulinomas in 5 dogs were imaged in vivo by means of indium in 111 pentetreotide (OctreoScan) scintigraphy. The diagnosis in each dog was supported by the presence of hypoglycemia (<60 mg/dL), hyperinsulinemia (>20 microU/mL), and histopathologic review of neoplastic tissue. All insulinomas expressed high-affinity somatostatin receptors of subtype sst2, as shown by receptor autoradiography in vitro using 125I-[tyrosine3]-octreotide and 125I-[leucine8, Dtryptophan22, tyrosine25]-somatostatin-28 with an sst2 subtype-selective analogue. Scintigrams were obtained at 1, 4, 12, and 24 hours after the i.v. administration of 74-222 MBq of OctreoScan to each patient. Abnormal foci of activity were 1st observed from 1 hour after administration of the radioligand in dog 3, to 24 hours after its administration in dog 4; in dogs 1 and 2, abnormal foci of activity were visible from 12 hours. Dog 5 showed a questionable abnormal focus of activity at 12 hours, but not at 24 hours. Scintigraphy enabled accurate prediction of the anatomical location of the primary tumor in 1 of 4 dogs, but was unable to differentiate a right- from a left-pancreatic lobe tumor, or vice versa, in 3 dogs; the 5th dog had equivocal results. 111In-pentetreotide scintigraphy is a useful diagnostic adjunct to the clinical evaluation of the insulinoma patient, but is unable to localize the tumor in some cases.  相似文献