OBITUARY     

Haas WH  Schilt J 《Science (New York, N.Y.)》1932,76(1973):358-360

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Comparative functional genomics of the fission yeasts     

Rhind N  Chen Z  Yassour M  Thompson DA  Haas BJ  Habib N  Wapinski I  Roy S  Lin MF  Heiman DI  Young SK  Furuya K  Guo Y  Pidoux A  Chen HM  Robbertse B  Goldberg JM  Aoki K  Bayne EH  Berlin AM  Desjardins CA  Dobbs E  Dukaj L  Fan L  FitzGerald MG  French C  Gujja S  Hansen K  Keifenheim D  Levin JZ  Mosher RA  Müller CA  Pfiffner J  Priest M  Russ C  Smialowska A  Swoboda P  Sykes SM  Vaughn M  Vengrova S  Yoder R  Zeng Q  Allshire R  Baulcombe D  Birren BW  Brown W  Ekwall K  Kellis M  Leatherwood J  Levin H  Margalit H  Martienssen R 《Science (New York, N.Y.)》2011,332(6032):930-936

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Genome sequence of Aedes aegypti, a major arbovirus vector     

Nene V  Wortman JR  Lawson D  Haas B  Kodira C  Tu ZJ  Loftus B  Xi Z  Megy K  Grabherr M  Ren Q  Zdobnov EM  Lobo NF  Campbell KS  Brown SE  Bonaldo MF  Zhu J  Sinkins SP  Hogenkamp DG  Amedeo P  Arensburger P  Atkinson PW  Bidwell S  Biedler J  Birney E  Bruggner RV  Costas J  Coy MR  Crabtree J  Crawford M  Debruyn B  Decaprio D  Eiglmeier K  Eisenstadt E  El-Dorry H  Gelbart WM  Gomes SL  Hammond M  Hannick LI  Hogan JR  Holmes MH  Jaffe D  Johnston JS  Kennedy RC  Koo H  Kravitz S  Kriventseva EV  Kulp D  Labutti K  Lee E  Li S  Lovin DD 《Science (New York, N.Y.)》2007,316(5832):1718-1723

We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.  相似文献   

KOI-126: a triply eclipsing hierarchical triple with two low-mass stars     

Carter JA  Fabrycky DC  Ragozzine D  Holman MJ  Quinn SN  Latham DW  Buchhave LA  Van Cleve J  Cochran WD  Cote MT  Endl M  Ford EB  Haas MR  Jenkins JM  Koch DG  Li J  Lissauer JJ  MacQueen PJ  Middour CK  Orosz JA  Rowe JF  Steffen JH  Welsh WF 《Science (New York, N.Y.)》2011,331(6017):562-565

The Kepler spacecraft has been monitoring the light from 150,000 stars in its primary quest to detect transiting exoplanets. Here, we report on the detection of an eclipsing stellar hierarchical triple, identified in the Kepler photometry. KOI-126 [A, (B, C)], is composed of a low-mass binary [masses M(B) = 0.2413 ± 0.0030 solar mass (M(⊙)), M(C) = 0.2127 ± 0.0026 M(⊙); radii R(B) = 0.2543 ± 0.0014 solar radius (R(⊙)), R(C) = 0.2318 ± 0.0013 R(⊙); orbital period P(1) = 1.76713 ± 0.00019 days] on an eccentric orbit about a third star (mass M(A) = 1.347 ± 0.032 M(⊙); radius R(A) = 2.0254 ± 0.0098 R(⊙); period of orbit around the low-mass binary P(2) = 33.9214 ± 0.0013 days; eccentricity of that orbit e(2) = 0.3043 ± 0.0024). The low-mass pair probe the poorly sampled fully convective stellar domain offering a crucial benchmark for theoretical stellar models.  相似文献   

Genome-wide RNAi analysis of growth and viability in Drosophila cells     

Boutros M  Kiger AA  Armknecht S  Kerr K  Hild M  Koch B  Haas SA  Paro R  Perrimon N;Heidelberg Fly Array Consortium 《Science (New York, N.Y.)》2004,303(5659):832-835

A crucial aim upon completion of whole genome sequences is the functional analysis of all predicted genes. We have applied a high-throughput RNA-interference (RNAi) screen of 19,470 double-stranded (ds) RNAs in cultured cells to characterize the function of nearly all (91%) predicted Drosophila genes in cell growth and viability. We found 438 dsRNAs that identified essential genes, among which 80% lacked mutant alleles. A quantitative assay of cell number was applied to identify genes of known and uncharacterized functions. In particular, we demonstrate a role for the homolog of a mammalian acute myeloid leukemia gene (AML1) in cell survival. Such a systematic screen for cell phenotypes, such as cell viability, can thus be effective in characterizing functionally related genes on a genome-wide scale.  相似文献   

Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion     

Odenbreit S  Püls J  Sedlmaier B  Gerland E  Fischer W  Haas R 《Science (New York, N.Y.)》2000,287(5457):1497-1500

The Gram-negative bacterium Helicobacter pylori is a causative agent of gastritis and peptic ulcer disease in humans. Strains producing the CagA antigen (cagA(+)) induce strong gastric inflammation and are strongly associated with gastric adenocarcinoma and MALT lymphoma. We show here that such strains translocate the bacterial protein CagA into gastric epithelial cells by a type IV secretion system, encoded by the cag pathogenicity island. CagA is tyrosine-phosphorylated and induces changes in the tyrosine phosphorylation state of distinct cellular proteins. Modulation of host cells by bacterial protein translocation adds a new dimension to the chronic Helicobacter infection with yet unknown consequences.  相似文献   

Ralph R. Parker: 1888-1949     

Haas VH 《Science (New York, N.Y.)》1950,111(2873):56-57

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Evaluation of aerosol devices for simultaneous disruption of sex pheromone communication in <Emphasis Type="Italic">Cydia pomonella</Emphasis> and <Emphasis Type="Italic">Grapholita molesta</Emphasis> (Lepidoptera: Tortricidae)     

L. L. Stelinski  L. J. Gut  M. Haas  P. McGhee  D. Epstein 《Journal of pest science》2007,80(4):225-233

A two-year study was conducted evaluating Puffer^® aerosol dispensers (Suterra LLC, Bend, OR, USA) for mating disruption of codling moth, Cydia pomonella (L.), and the oriental fruit moth, Grapholita molesta (Busck). The Puffer^® dispenser consists of a pressurized metal canister loaded with pheromone active ingredients dissolved in solvent and housed within a circuit-controlled, plastic dispensing cabinet programmed to release an aerosol spray of pheromone at regular intervals. Puffers^® were deployed at the label-recommended rate of 2.5 ha^?1 and released ca. 5–10 mg of pheromone (depending on treatment) per 15 min during a 12-h cycle beginning each day at 15:00 h for the duration of the season. In 2005, commercially-managed apple plots (3.2–4.9 ha) were treated with Puffers^® releasing both species’ pheromone simultaneously (dual-species) or with twice the number of adjacently-deployed Puffers^® (4–6 m apart) releasing each individual species’ pheromones (single-species), while maintaining comparable overall release rates of pheromone between these two treatments. Plots 100 m away and not treated with pheromone served as the control. Disruption of male C. pomonella and G. molesta orientation to pheromone-baited traps was 46–75 and 91–98%, respectively, in Puffer^®-treated plots compared with untreated controls. There was no statistical difference in moth disruption between plots treated with dual-species and single-species Puffers^®. Fruit injury was not statistically different between Puffer^®-treated plots and control plots not receiving pheromone. In 2006, disruption of male moth orientation to traps was 24–26 and 84–97% in Puffer^®-treated plots (2.9–5.7 ha) for C. pomonella and G. molesta, respectively, compared with untreated controls. During this season, fruit injury was lower in pheromone-treated plots compared with untreated controls at mid-season, but not at pre-harvest. Combining the pheromone of both species into single Puffer^® units did not decrease efficacy of disruption compared with deploying twice as many Puffers^® releasing a similar amount of each individual species’ pheromone suggesting that multi-species disruption using Puffers^® is a viable option. However, we conclude that the efficacy of disruption attained with low-densities (2.5 ha^?1) of Puffers^® at the moth densities recorded in this study is insufficient for effective control of C. pomonella without input of companion insecticides.  相似文献