Safety and immunogenicity of a delta inulin-adjuvanted inactivated Japanese encephalitis virus vaccine in pregnant mares and foals     

Helle Bielefeldt-Ohmann  Natalie A Prow  Wenqi Wang  Cindy SE Tan  Mitchell Coyle  Alysha Douma  Jody Hobson-Peters  Lisa Kidd  Roy A Hall  Nikolai Petrovsky 《Veterinary research》2014,45(1)

In 2011, following severe flooding in Eastern Australia, an unprecedented epidemic of equine encephalitis occurred in South-Eastern Australia, caused by Murray Valley encephalitis virus (MVEV) and a new variant strain of Kunjin virus, a subtype of West Nile virus (WNV_KUN). This prompted us to assess whether a delta inulin-adjuvanted, inactivated cell culture-derived Japanese encephalitis virus (JEV) vaccine (JE-ADVAX™) could be used in horses, including pregnant mares and foals, to not only induce immunity to JEV, but also elicit cross-protective antibodies against MVEV and WNV_KUN. Foals, 74–152 days old, received two injections of JE-ADVAX™. The vaccine was safe and well-tolerated and induced a strong JEV-neutralizing antibody response in all foals. MVEV and WNV_KUN antibody cross-reactivity was seen in 33% and 42% of the immunized foals, respectively. JE-ADVAX™ was also safe and well-tolerated in pregnant mares and induced high JEV-neutralizing titers. The neutralizing activity was passively transferred to their foals via colostrum. Foals that acquired passive immunity to JEV via maternal antibodies then were immunized with JE-ADVAX™ at 36–83 days of age, showed evidence of maternal antibody interference with low peak antibody titers post-immunization when compared to immunized foals of JEV-naïve dams. Nevertheless, when given a single JE-ADVAX™ booster immunization as yearlings, these animals developed a rapid and robust JEV-neutralizing antibody response, indicating that they were successfully primed to JEV when immunized as foals, despite the presence of maternal antibodies. Overall, JE-ADVAX™ appears safe and well-tolerated in pregnant mares and young foals and induces protective levels of JEV neutralizing antibodies with partial cross-neutralization of MVEV and WNV_KUN.  相似文献   

Admixture analysis in relation to pedigree studies of introgression in a minority British cattle breed: the Lincoln Red     

T.C. Bray  S.J.G. Hall  M.W. Bruford 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2014,131(1):19-26

Investigation of historic population processes using molecular data has been facilitated by the use of approximate Bayesian computation (ABC), which enables the consideration of multiple alternative demographic scenarios. The Lincoln Red cattle breed provides a relatively simple example of two well‐documented admixture events. Using molecular data for this breed, we found that structure did not resolve very low (<5% levels) of introgression, possibly due to sampling limitations. We evaluated the performance of two ABC approaches (2BAD and DIYABC) against those of two earlier methodologies, ADMIX and LEADMIX, by comparing their interpretations with the conclusions drawn from herdbook analysis. The ABC methods gave credible values for the proportions of the Lincoln Red genotype that are attributable to Aberdeen Angus and Limousin, although estimates of effective population size and event timing were not realistic. We suggest ABC methods are a valuable supplement to pedigree‐based studies but that the accuracy of admixture determination is likely to diminish with increasing complexity of the admixture scenario.  相似文献   

The veterinary trauma initiative: Why bother?     

Kelly Hall DVM  MS  DACVECC  Claire Sharp BSc  BVM  MS  DACVECC 《Journal of Veterinary Emergency and Critical Care》2014,24(6):639-641

  相似文献   

A multiple regression model of oyster growth     

Steven Hall 《Fisheries Research》1984,2(3):167-175

A deterministic model of the growth in the sea of Ostrea edulis and Crassostrea gigas has been developed from published information. The model is a multiple regression function in which oyster size and seawater temperature are treated as determinants of instantaneous growth rate. Simulation of commercial cultivation with the model is described.  相似文献   

Determination of the Sea Age of Atlantic Salmon in Scottish Catches from Length Composition Data     

D. J. Pratten  E. D. McCallum  W. B. Hall 《Aquaculture Research》1982,13(4):159-162

The importance of obtaining reliable estimates of the sea age composition of reported salmon catches are discussed. The use of length frequency distributions to determine the sea age of salmon in samples taken from the North Esk commercial catch are described. The results obtained using this technique are compared to those obtained from scale reading on a 4 weekly basis over a 16-year period. The use of length frequencies is shown to provide a reliable estimate of the sea age composition of catch samples. The adoption of this technique in catch sampling programmes is labour saving and facilitates rapid sampling.  相似文献   

Diagnosis and management of small-scale fisheries in developing countries   总被引：2，自引：0，他引：2  

Neil L Andrew  Christophe Béné  Stephen J Hall  Edward H Allison  Simon Heck  & Blake D Ratner 《Fish and Fisheries》2007,8(3):227-240

Small‐scale fisheries (SSF) make important but undervalued contributions to the economies of some of the world’s poorest countries. They also provide much of the animal protein needed by societies in which food security remains a pressing issue. Assessment and management of these fisheries is usually inadequate or absent and they continue to fall short of their potential as engines for development and social change. In this study, we bring together existing theory and methods to suggest a general scheme for diagnosing and managing SSF. This approach can be adapted to accommodate the diversity of these fisheries in the developing world. Many threats and solutions to the problems that beset SSF come from outside the domain of the fishery. Significant improvements in prospects for fisheries will require major changes in societal priorities and values, with consequent improvements in policy and governance. Changes in development policy and science reflect these imperatives but there remains a need for intra‐sectoral management that builds resilience and reduces vulnerability to those forces beyond the influence of small‐scale fishers.  相似文献   

Eight urgent,fundamental and simultaneous steps needed to restore ocean health,and the consequences for humanity and the planet of inaction or delay     

Dan Laffoley  John M. Baxter  Diva J. Amon  Duncan E.J. Currie  Craig A. Downs  Jason M. Hall‐Spencer  Harriet Harden‐Davies  Richard Page  Chris P. Reid  Callum M. Roberts  Alex Rogers  Thorsten Thiele  Charles R.C. Sheppard  Rashid U. Sumaila  Lucy C. Woodall 《水产资源保护:海洋与淡水生态系统》2020,30(1):194-208

1. The ocean crisis is urgent and central to human wellbeing and life on Earth; past and current activities are damaging the planet's main life support system for future generations. We are witnessing an increase in ocean heat, disturbance, acidification, bio‐invasions and nutrients, and reducing oxygen levels. Several of these act like ratchets: once detrimental or negative changes have occurred, they may lock in place and may not be reversible, especially at gross ecological and ocean process scales.
2. Each change may represent a loss to humanity of resources, ecosystem function, oxygen production and species. The longer we pursue unsuitable actions, the more we close the path to recovery and better ocean health and greater benefits for humanity in the future.
3. We stand at a critical juncture and have identified eight priority issues that need to be addressed in unison to help avert a potential ecological disaster in the global ocean. They form a purposely ambitious agenda for global governance and are aimed at informing decision‐makers at a high level. They should also be of interest to the general public.
4. Of all the themes, the highest priority is to rigorously address global warming and limit surface temperature rise to 1.5°C by 2100, as warming is the pre‐eminent factor driving change in the ocean. The other themes are establishing a robust and comprehensive High Seas Treaty, enforcing existing standards for Marine Protected Areas and expanding their coverage, especially in terms of high levels of protection, adopting a precautionary pause on deep‐sea mining, ending overfishing and destructive fishing practices, radically reducing marine pollution, putting in place a financing mechanism for ocean management and protection, and lastly, scaling up science/data gathering and facilitating data sharing.
5. By implementing all eight measures in unison, as a coordinated strategy, we can build resilience to climate change, help sustain fisheries productivity, particularly for low‐income countries dependent on fisheries, protect coasts (e.g. via soft‐engineering/habitat‐based approaches), promote mitigation (e.g. carbon storage) and enable improved adaptation to rapid global change.

  相似文献   

STEREOCHEMICAL THEORY     

Hall TP 《Science (New York, N.Y.)》1894,23(580):147-148

  相似文献   

Dysentery caused by Escherichia coli (S102-9) in calves: natural and experimental disease   总被引：10，自引：0，他引：10  

G A Hall  D J Reynolds  N Chanter  J H Morgan  K R Parsons  T G Debney  A P Bland  J C Bridger 《Veterinary pathology》1985,22(2):156-163

A dysentery syndrome was recognized among the Institute's calves at 18 to 21 days of age. It was reproduced experimentally in gnotobiotic calves with an atypical Escherichia coli (S102-9) isolated from the affected calves. In both natural and experimental disease the calves passed copious bright red blood in the feces and developed diarrhea. Walls of the colon and rectum were thickened, and the mucosa was reddened and covered by an exudate that contained mucus and blood clots. Bacteria were seen closely adherent to the luminal surfaces of enterocytes, often in cup-shaped depressions or on cytoplasmic pedestals. Microvilli were distorted, disorientated or absent. There was exfoliation of infected enterocytes and a mild acute inflammation of the underlying lamina. In two of five calves with natural disease, the adherent bacteria did not stain by the immunoperoxidase method with antisera raised against E. coli (S102-9). This indicated that there was possibly more than one bacterial cause of the syndrome. Lesions in experimentally infected calves were indistinguishable from those produced by some E. coli which are enteropathogenic for man, rabbits, and pigs.  相似文献   

The Conspiracy of Silence     

Hall A 《Science (New York, N.Y.)》1888,11(259):37-38

  相似文献