Hypercalcemia and high parathyroid hormone-related peptide concentration in a dog with a complex mammary carcinoma     

Bae BK  Kim CW  Choi US  Choi EW  Jee H  Kim DY  Lee CW 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2007,36(4):376-378

A 10-year-old female Dachshund was presented with a history of mammary masses, slight lethargy, polyuria, and polydipsia. Physical examination findings included masses involving the first, second, and fourth mammary glands of the left side. The mandibular, axillary, and right popliteal lymph nodes were mildly enlarged. Serum chemistry results included hypercalcemia (13.9 mg/dL, reference interval 8.0-11.5 mg/dL). Although intact parathyroid hormone (PTH) concentration (1.05 pmol/L) was below the reference interval (2-13 pmol/L), PTH-related protein (PTHrP) concentration was markedly increased (9.40 pmol/L, reference value < 2 pmol/L). The masses were surgically removed, and the histopathologic diagnosis was complex mammary carcinoma. Three weeks after surgery, serum total calcium concentration had decreased to 10.5 mg/dL. Resolution of the hypercalcemia and clinical signs supported a diagnosis of humoral hypercalcemia of malignancy associated with mammary gland carcinoma.  相似文献   

Overexpression of OCT4A ortholog elevates endogenous XIST in porcine parthenogenic blastocysts     

Jae Yeon HWANG  Kwang-Hwan CHOI  Dong-Kyung LEE  Seung-Hun KIM  Eun Bae KIM  Sang-Hwan HYUN  Chang-Kyu LEE 《The Journal of reproduction and development》2015,61(6):533-540

X-chromosome inactivation (XCI) is an epigenetic process that equalizes expression of X-borne genes between male and female eutherians. This process is observed in early eutherian embryo development in a species-specific manner. Until recently, various pluripotent factors have been suggested to regulate the process of XCI by repressing XIST expression, which is the master inducer for XCI. Recent insights into the process and its regulation have been restricted in mouse species despite the evolutionary diversity of the process and molecular mechanism among the species. OCT4A is one of the represented pluripotent factors, the gate-keeper for maintaining pluripotency, and an XIST repressor. Therefore, in here, we examined the relation between OCT4A and X-linked genes in porcine preimplantation embryos. Three X-linked genes, XIST, LOC102165544, and RLIM, were selected in present study because their orthologues have been known to regulate XCI in mice. Expression levels of OCT4A were positively correlated with XIST and LOC102165544 in female blastocysts. Furthermore, overexpression of exogenous human OCT4A in cleaved parthenotes generated blastocysts with increased XIST expression levels. However, increased XIST expression was not observed when exogenous OCT4A was obtained from early blastocysts. These results suggest the possibility that OCT4A would be directly or indirectly involved in XIST expression in earlier stage porcine embryos rather than blastocysts.  相似文献   

Employment of hordein subunit polymorphisms in establishing selection criteria for high quality malting barley (Hordeum vulgare L.)     

Yong Jin Lee  Tong Geon Lee  Woong Bae Jeon  Dae Yeon Kim  Min Jeong Hong  Man Bo Lee  Jong Nae Hyun  Mi Jung Kim  Mi Ja Lee  Cheol Su Park  Yong Weon Seo 《Journal of Crop Science and Biotechnology》2010,13(2):91-97

Cereal seed storage proteins are encoded by complex multigene families and their subunit profiles are highly related to end-use qualities. Each fraction of albumin and hordein was extracted and its subunit profile was evaluated in related to malt and grain quality parameters. The purpose of this study was to provide selection criteria for high quality malting barley using grain and malt quality parameters and biochemical-genetic information. Grain and malt quality of 13 local adaptability test (LAT) lines were evaluated for malting process. A total of 16 germplasm accessions of high or low seed storage protein content were also evaluated for biochemicalgenetic analysis. The correlation coefficients among quality parameters were analyzed. Several important quality parameters in brewing process showed significant positive or negative correlations. Seed storage protein subunits of albumin and hordein of all tested lines and accessions were evaluated using 12% 1D SDS-PAGE. Scored data of protein subunit’s presence or absence was applied to Agglomerative Hierarchical Clustering (AHC) for statistical analysis and showed specific grouping patterns among tested lines. Clustered lines with subunit information were highly related with agricultural performance and grain and malt qualities. Based on the profiles of seed storage protein subunits, association of hordein subunit of 38, 43, and 65 kDa with high malt scored lines was found. The obtained results would provide improved selection criteria for high quality malting barley in the malting barley breeding program.  相似文献   

Microscopic observation of wood-based composites exposed to fungal deterioration     

Woo-Yang Chung  Seung-Gon Wi  Hyeun-Jong Bae  Byung-Dae Park 《Journal of Wood Science》1999,45(1):64-68

This study was conducted to investigate the susceptibility of various wood composite panels exposed to wood-deteriorating fungi. Five wood-attacking fungi (three mold fungi, one brown rot fungus, one white rot fungus) were inoculated into four types of commercial wood composite panels (plywood, oriented strand board, particleboard, and medium-density fiberboard). One solid wood sample was included as a control. The attacking patterns of the fungi in each panel was observed by scanning electron microscopy. The weight losses due to the exposure were compared. All wood composites were more or less susceptible to all fungi inoculated. The attacking mode of the fungi was highly dependent on the types of wood composite, which had inherently different shapes of voids owing to different shapes and characteristics of the raw furnish materials used. Plywood and medium-density fiberboard showed a large weight loss after an 8-week exposure to decay fungi. Plywood is the most susceptible to white and brown rot fungi. This study indicates that all wood composite panels should undergo careful consideration to prevent fungal deterioration when they are used for exterior and humid interior applications.  相似文献   

Solvatochromism of indonaphthol dye     

Jin-Seok Bae  Young-A Son  Sung-Hoon Kim 《Fibers and Polymers》2008,9(5):659-660

The solvatochromic behavior of indonaphthol dye was described. The UV/Vis absorption spectra of this compound have been studied in 5 solvents of different polarity. The solvatochromism of indonaphthol dye is discussed with the aid of semiempirical calculations.  相似文献   

Synthesis and application of alkyl-substituted disazo yellow dyes for unmodified polypropylene fiber     

Taekyeong Kim  Jongsuc Jung  Songi Son  Seokhan Yoon  Mikyung Kim  Jin-Seok Bae 《Fibers and Polymers》2008,9(5):538-543

The several disazo dyes having different alkyl substituents were synthesized to dye unmodified polypropylene fiber. The affinity of the dyes onto unmodified polypropylene was increased with the increase of the length of alkyl substituents. Therefore, the heptyl-substituted dye having the longest alkyl group in this experiment showed very high color strength of dyeings with K/S value of over 24 at maximum absorption wavelength. The color fastnesses to washing, rubbing and light were also improved significantly for the longer alkyl substituted dyes, so that the heptyl-substituted dye exhibited a rating of 4∼5 for all kinds of fastnesses.  相似文献   

New fluorescent dye chemosensor for mercury ion (Hg2+) detection     

Young-A Son  Ji-Hyun Hwang  Sheng Wang  Jin-Seok Bae  Sung-Hoon Kim 《Fibers and Polymers》2009,10(2):272-274

The dye chemosensor for mercury ion detection was designed, which was based on donor-acceptor intramolecular charge transfer system and the corresponding fluorescence changing property was successfully monitored. This new dye chemosensor was containing dimethylcarbamodithioate groups to coordinate Hg²⁺, which showed very effective sensing functions. But it showed no significant changes upon the addition of other metal ions such as Ca²⁺, Pb²⁺, Al³⁺, Ce²⁺, Ba²⁺, Ni²⁺, Cd²⁺, Zn²⁺, and Mg²⁺.  相似文献   

A new flavonoid glycoside from the leaf of Cephalotaxus koreana     

Bae K  Jin W  Thuong PT  Min BS  Na M  Lee YM  Kang SS 《Fitoterapia》2007,78(6):409-413

A new flavone glycoside, apigenin 5-O-alpha-L-rhamnopyranosyl-(1-->3)-beta-D-glucopyranoside (1), along with four known flavonol glycosides (2-5), were isolated from the leaf of Cephalotaxus koreana. The new glycoside 1 showed inhibitory activity in superoxide radical scavenging assay with IC(50) value of 13.0 microM, while it showed weak activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Compounds 2-5 exhibited antioxidant activity in scavenging DPPH and superoxide radicals with IC(50) values ranging from 5.7 to 22.3 microM.  相似文献   

Successful treatment of canine infective endocarditis caused by Bacillus amyloliquefaciens     

Hyeona Bae  Tae-Sung Hwang  Hee-Chun Lee  Dong-In Jung  Sang-Hyun Kim  DoHyeon Yu 《The Veterinary quarterly》2022,42(1):41

Bacillus amyloliquefaciens is a gram-positive bacterial species that is utilised as a probiotic in humans and animals. There are no reports of infective endocarditis (IE) in dogs. An 8-year-old, spayed, female Maltese presented with a 1-month history of fever, depression, weight loss, and hindlimb lameness. Laboratory test results indicated non-regenerative anaemia, neutrophilia, hyperglobulinemia, and proteinuria. Echocardiography revealed vegetation on the septal leaflet of the mitral valve and thromboemboli in the left atrium. Consecutive blood culture results revealed that the blood samples were consistently positive for Bacillus amyloliquefaciens, which is generally considered a probiotic bacterial species for animals. Broad-spectrum antibiotics (amoxicillin-clavulanic acid and cefotaxime) and anticoagulants (clopidogrel and rivaroxaban) were administered for 4 months. The clinical signs were responsive to antibiotic treatment. After 4 months, the dog was no longer febrile and the size of the thromboemboli in the left atrium had decreased. Bacteria were no longer isolated in blood cultures after antibiotic therapy. To the best of our knowledge, this is the first case report of canine IE caused by bactaeremic infection with Bacillus amyloliquefaciens.  相似文献   

Binding,Antioxidant and Anti-proliferative Properties of Bioactive Compounds of Sweet Paprika (Capsicum annuum L.)     

Hong-Gi Kim  Jong-Hyang Bae  Zenon Jastrzebski  Andriy Cherkas  Buk-Gu Heo  Shela Gorinstein  Yang-Gyu Ku 《Plant foods for human nutrition (Dordrecht, Netherlands)》2016,71(2):129-136

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