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A retrospective study of the medical records of 33 horses was performed to determine the clinical and diagnostic abnormalities associated with temporohyoid osteoarthropathy. Data collected from medical records included signalment, presenting complaints, history, physical examination findings, laboratory data, results of diagnostic imaging studies, and treatments. Follow-up information was obtained from a review of case records; by telephone conversation with the owner, veterinarian, or trainer; or by both methods. Of 33 horses with temporohyoid osteoarthropathy, 29 presented with facial nerve (cranial nerve VII) deficits and 23 presented with vestibulocochlear nerve (cranial nerve VIII) deficits. Guttural pouch endoscopy was more reliable than radiography for diagnosis. Of horses with unilateral clinical signs, 22.6% actually had bilateral disease. Magnetic resonance imaging and computed tomography identified the lesions in all horses in which these tests were performed. Of 30 horses for which follow-up information was obtained, 20 (67%) were alive. Eight horses were euthanized and 1 died because of problems associated with temporohyoid osteoarthropathy. Nineteen of 20 surviving horses (95%) were considered by the owner or trainer to be suitable for athletic use. Twelve surviving horses (60%) had residual facial nerve deficits; 11 horses (55%) had residual vestibulocochlear nerve deficits. Horses with temporohyoid osteoarthropathy have a fair prognosis for return to some type of athletic function, but there is risk of acute death. The majority of horses would be expected to have some residual cranial nerve dysfunction, and it could take a year or longer for maximal improvement to occur.  相似文献   
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Seven young horses 5 to 12 months old, each diagnosed with proliferative enteropathy, were studied. All seven cases responded to alternative antimicrobial therapy to the traditional treatment of erythromycin ± rifampin. Three cases were treated with chloramphenicol, two cases with doxycycline, one with azithromycin, and one with clarithromycin and rifampin. All showed resolution of clinical and clinicopathological abnormalities within 8 weeks of initiation of treatment. Proliferative enteropathy is an increasingly recognized malabsorptive and maldigestive disease of young horses. Supportive care and antimicrobial therapy are the mainstays of therapy with erythromycin being the traditional antibiotic of choice. The knowledge that alternative therapeutic antimicrobials are clinically efficacious in the treatment of Lawsonia intracellularis broadens the therapeutic options for this potentially fatal condition.  相似文献   
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PPID in older equids has become a major health concern of horse owners. In response, equine practitioners have made greater efforts at understanding, diagnosing, and treating this disorder. Although PPID is recognized to be a different form of pituitary-dependent hyperadrenocorticism than is seen in canine or human patients, relatively little is known about the pathophysiology and natural progression of the disease. At present, the diagnosis is best supported by manifestation of characteristic clinical signs and endocrinologic test results, preferably a supportive DST result. Treatment must focus on improving overall health care, including body clipping, dentistry, and nutrition. As the condition progresses, administration of pergolide or a combination of pergolide and cyproheptadine is currently considered the best medical treatment. The time point at which medication should be added to improved health care and management changes is not currently known, but loss of body condition and development of hyperglycemia suggest more advanced PPID that would likely benefit from drug therapy. Whether medical treatment needs to be continuous or could be intermittent is also unknown. As the demand for treatment of affected equids continues to increase, clinical response and endocrinologic testing data as well as pharmacologic data for currently used drugs and other agents should be expected. Similarly, novel medical, and perhaps surgical, treatment strategies for this condition should also be anticipated in the future.  相似文献   
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The development of food surveys for levels of pesticide residues, toxic metals and polychlorobiphenyls and related compounds is outlined. The role of the surveys in monitoring the effect on the levels of compounds in specific foods following changes in pesticide usage is explained. Studies over 8 years on levels in the total diet show they are well below the acceptable daily intakes recommended by the Food and Agriculture Organisation/World Health Organisation for organchlorine and other pesticides. During this period the levels found have in general declined.  相似文献   
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An acute respiratory disease in a colony of Wistar-derived rats is described. The infection, due to Diplococcus pneumoniae type 16, has apparently not been described previously in the rat. Rigid sanitary measures and treatment with penicillin were effective in controlling the disease.  相似文献   
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