SOIL ACIDITY AND METHODS FOR ITS DETECTION     

Harris JE 《Science (New York, N.Y.)》1914,40(1031):491-493

  相似文献   

THE LUNELL HERBARIUM     

Harris JA 《Science (New York, N.Y.)》1927,66(1700):110

  相似文献   

Sustainability. Anchovy fishery threat to Patagonian ecosystem     

Skewgar E  Boersma PD  Harris G  Caille G 《Science (New York, N.Y.)》2007,315(5808):45

  相似文献   

Nonmethylated transposable elements and methylated genes in a chordate genome     

Simmen MW  Leitgeb S  Charlton J  Jones SJ  Harris BR  Clark VH  Bird A 《Science (New York, N.Y.)》1999,283(5405):1164-1167

The genome of the invertebrate chordate Ciona intestinalis was found to be a stable mosaic of methylated and nonmethylated domains. Multiple copies of an apparently active long terminal repeat retrotransposon and a long interspersed element are nonmethylated and a large fraction of abundant short interspersed elements are also methylation free. Genes, by contrast, are predominantly methylated. These data are incompatible with the genome defense model, which proposes that DNA methylation in animals is primarily targeted to endogenous transposable elements. Cytosine methylation in this urochordate may be preferentially directed to genes.  相似文献   

Neural differentiation: from message to mind     

Harris WA 《Science (New York, N.Y.)》1988,240(4849):229

  相似文献   

Mutational inactivation of STAG2 causes aneuploidy in human cancer     

Solomon DA  Kim T  Diaz-Martinez LA  Fair J  Elkahloun AG  Harris BT  Toretsky JA  Rosenberg SA  Shukla N  Ladanyi M  Samuels Y  James CD  Yu H  Kim JS  Waldman T 《Science (New York, N.Y.)》2011,333(6045):1039-1043

Most cancer cells are characterized by aneuploidy, an abnormal number of chromosomes. We have identified a clue to the mechanistic origins of aneuploidy through integrative genomic analyses of human tumors. A diverse range of tumor types were found to harbor deletions or inactivating mutations of STAG2, a gene encoding a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Because STAG2 is on the X chromosome, its inactivation requires only a single mutational event. Studying a near-diploid human cell line with a stable karyotype, we found that targeted inactivation of STAG2 led to chromatid cohesion defects and aneuploidy, whereas in two aneuploid human glioblastoma cell lines, targeted correction of the endogenous mutant alleles of STAG2 led to enhanced chromosomal stability. Thus, genetic disruption of cohesin is a cause of aneuploidy in human cancer.  相似文献   

Electron solvation in two dimensions     

Miller AD  Bezel I  Gaffney KJ  Garrett-Roe S  Liu SH  Szymanski P  Harris CB 《Science (New York, N.Y.)》2002,297(5584):1163-1166

Ultrafast two-photon photoemission has been used to study electron solvation at two-dimensional metal/polar-adsorbate interfaces. The molecular motion that causes the excess electron solvation is manifested as a dynamic shift in the electronic energy. Although the initially excited electron is delocalized in the plane of the interface, interactions with the adsorbate can lead to its localization. A method for determining the spatial extent of the localized electron in the plane of the interface has been developed. This spatial extent was measured to be on the order of a single adsorbate molecule.  相似文献   

Genetics. Ethical aspects of ES cell-derived gametes     

Testa G  Harris J 《Science (New York, N.Y.)》2004,305(5691):1719

  相似文献   

THE EFFECT OF SOIL CONDITIONS ON THE TASSELS OF MAIZE     

Harris FS 《Science (New York, N.Y.)》1914,40(1023):215-216

  相似文献   

Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps     

Murphy WJ  Larkin DM  Everts-van der Wind A  Bourque G  Tesler G  Auvil L  Beever JE  Chowdhary BP  Galibert F  Gatzke L  Hitte C  Meyers SN  Milan D  Ostrander EA  Pape G  Parker HG  Raudsepp T  Rogatcheva MB  Schook LB  Skow LC  Welge M  Womack JE  O'brien SJ  Pevzner PA  Lewin HA 《Science (New York, N.Y.)》2005,309(5734):613-617

The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.  相似文献