Acute thallium toxicosis in a dog.     

C B Waters  E C Hawkins  D W Knapp 《Journal of the American Veterinary Medical Association》1992,201(6):883-885

A Doberman Pinscher was evaluated for acute onset of gastroenteritis, characterized by anorexia, hematemesis, and hematochezia. The dog had ingested mole bait containing thallium 2 days prior to admission. Thallium toxicosis was confirmed by detection of thallium in the urine, using colorimetric analysis. The dog responded well to administration of antibiotics, fluids administered IV, warm-water enemas, and oral administration of activated charcoal slurries.  相似文献   

The metabolic fate of tridemorph in rats     

David R. Hawkins  William H. Down  Leslie F. Chasseaud  John D. Lewis 《Pest management science》1974,5(5):535-542

A single oral dose of [¹⁴C]tridemorph was partly, but rapidly absorbed by rats. Most of the radioactivity was excreted with a half-life of about 15 h. During 5 days, 42.6% was excreted in the urine, 46.7% in the faeces, 1.5% in the expired air and 3.4 % was still retained. 24 % was excreted in the 48 h bile. Sequential wholebody autoradiography indicated that much of the radioactivity was confined to the gastrointestinal tract, liver and kidneys. There was no unexpected uptake of radioactivity. Urinary metabolites were more polar than tridemorph and were also detected in the bile and faeces. The major metabolite in 24 h urine, accounting for 22.3% of the dose appeared to be a side-chain hydroxylated derivative. Cleavage of the morpholine ring was limited to about 1.5 % of the dose.  相似文献   

Intranuclear inclusions of ganglion amphicytes in pigs.     

G A Wells  C N Hebert  S A Hawkins 《The Veterinary record》1979,104(24):552-553

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Inconsistencies in the absorptive capacities of Schirmer tear test strips     

E C Hawkins  C J Murphy 《Journal of the American Veterinary Medical Association》1986,188(5):511-513

The absorptive capacities of 4 commercially available tear test strips were determined and compared with 5-mm X 40-mm strips of #41 filter paper. Significant differences in the absorption of water over a given time interval were found in 3 of the groups tested. Major inconsistencies were found only within 1 lot of tear test strips from a single manufacturer. Tear test strips from this lot consisted of 2 distinct populations that were distinguishable by transillumination. Strips with widely spaced horizontal lines had the same absorptive capacity as the filter paper, whereas those with fine lines consistently absorbed less water. The clinical importance of this discrepancy was verified by comparing measurements of tear production in 6 normal dogs.  相似文献   

Tissue distribution of bovine spongiform encephalopathy infectivity in Romney sheep up to the onset of clinical disease after oral challenge   总被引：3，自引：0，他引：3  

Bellworthy SJ  Hawkins SA  Green RB  Blamire I  Dexter G  Dexter I  Lockey R  Jeffrey M  Ryder S  Berthelin-Baker C  Simmons MM 《The Veterinary record》2005,156(7):197-202

Sixty Romney sheep of three prion protein genotypes were dosed orally at six months of age with an inoculum prepared from the brains of cattle clinically affected with BSE, and 15 sheep were left undosed as controls. They were randomly assigned within genotype to groups and were sequentially euthanased and examined postmortem at intervals of six or 12 months, depending on their predicted susceptibility. Tissue pools prepared from the three, four or five dosed animals in each group were inoculated into groups of 20 RIII mice as a bioassay for infectivity. Separate inocula were prepared from the matched control sheep killed at each time. In the ARQ/ARQ sheep killed four months after inoculation, infectivity was detected in the Peyer's patch tissue pool, and at 10 months it was detected in the spleen pool; from 16 months, infectivity was detected in a range of nervous and lymphoreticular tissues, including the spinal cord pool, distal ileum excluding Peyer's patches, liver, Peyer's patches, mesenteric and prescapular lymph nodes, spleen, tonsil and cervical thymus. No infectivity was detected in the tissue pools from the ARQ/ARR and ARR/ARR sheep killed 10 months or 22 months after infection.  相似文献   

Natural transmission of BSE between sheep within an experimental flock     

Bellworthy SJ  Dexter G  Stack M  Chaplin M  Hawkins SA  Simmons MM  Jeffrey M  Martin S  Gonzalez L  Hill P 《The Veterinary record》2005,157(7):206

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Retinoblastoma in the eye of a llama (Llama glama)   总被引：1，自引：0，他引：1  

Fugaro MN  Kiupel M  Montiani-Ferreira F  Hawkins JF  Janovitz EB 《Veterinary ophthalmology》2005,8(4):287-290

ANIMAL STUDIED: A 6-year-old, pregnant female llama experienced a 6-month history of epiphora, buphthalmos, and acute loss of vision in the left eye. The condition was unresponsive to topical antimicrobial and anti-inflammatory therapy and progressed to corneal rupture. PROCEDURES: Transpalpebral enucleation was performed and an intraorbital silicone prosthesis was implanted. The eye was fixed in formalin and processed according to routine paraffin technique. Sections of a mass were immunohistochemically prepared routinely and stained for glial fibrillary acidic protein (GFAP), S-antigen, and rhodopsin. RESULTS: Gross, histopathologic, and immunohistochemical analysis revealed a retinal tumor consistent with a retinoblastoma. The neoplastic tissue formed Flexner-Wintersteiner and Homer-Wright rosettes, originated from the retina, and demonstrated photoreceptor differentiation with S-antigen and rhodopsin expression. Neoplastic cells were negative for GFAP. Four years after enucleation, the llama showed no signs of recurrent neoplasia. CONCLUSIONS: This report describes the diagnosis and successful treatment of the first known retinoblastoma in a llama.  相似文献   

A ROOT ROT OF CHRYSANTHEMUMS   总被引：1，自引：1，他引：0  

J. H. Hawkins  P. Wiggell  H. J. Wilcox 《Plant pathology》1963,12(1):21-22

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The handling of animal wastes   总被引：1，自引：0，他引：1  

J C Hawkins 《The Veterinary record》1978,102(8):162-165

Most farm problems with animal wastes occur in modern intensive livestock enterprises where manure is handled as a slurry. It is not practical to treat slurry in the same way as domestic sewage: it should be used on land as a source of plant nutrients. On most farms, this can be done only at certain times of the year and so slurry has to be stored. Storage gives rise to problems of mixing, handling, application, pollution, smell and pathogen survival which can often be solved by separating slurry with special machinery into solid and liquid fractions. Where odour is a serious problem, however, some form of limited aeration will usually provide the best solution. For intensive pig units on limited land close to houses, the NIAE has evolved a new system of slurry treatment which can convert all the slurry from a fattening piggery into inoffensive solids. When incorporated into a piggery for 500 pigs being planned by the Ministry of Agriculture, Fisheries and Food, the system should also reduce smell substantially both inside and outside the building.  相似文献   

Choroiditis and cataracts in Atlantic salmon (Salmo salar L) recovering from subzero water temperatures     

Ferguson HW  Hawkins L  MacPhee DD  Bouchard D 《The Veterinary record》2004,155(11):333-334

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