Recoupling cross-scale interactions in tall fescue-invaded tallgrass prairie     

Raynor  Edward J.  Hillhouse  Heidi L.  Debinski  Diane M.  Miller  James R.  Schacht  Walter H. 《Landscape Ecology》2022,37(1):267-283

Landscape Ecology - Vegetation quantity and quality influence the degree to which large grazers shape grassland structural heterogeneity. Invasive plants threaten the function of cross-scale...  相似文献   

Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation     

Rosebeck S  Madden L  Jin X  Gu S  Apel IJ  Appert A  Hamoudi RA  Noels H  Sagaert X  Van Loo P  Baens M  Du MQ  Lucas PC  McAllister-Lucas LM 《Science (New York, N.Y.)》2011,331(6016):468-472

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Tuberculosis in North Korea     

Perry S  Linton H  Schoolnik G 《Science (New York, N.Y.)》2011,331(6015):263

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Erythrocyte G protein-coupled receptor signaling in malarial infection     

Harrison T  Samuel BU  Akompong T  Hamm H  Mohandas N  Lomasney JW  Haldar K 《Science (New York, N.Y.)》2003,301(5640):1734-1736

Erythrocytic mechanisms involved in malarial infection are poorly understood. We have found that signaling via the erythrocyte beta2-adrenergic receptor and heterotrimeric guanine nucleotide-binding protein (Galphas) regulated the entry of the human malaria parasite Plasmodium falciparum. Agonists that stimulate cyclic adenosine 3',5'-monophosphate production led to an increase in malarial infection that could be blocked by specific receptor antagonists. Moreover, peptides designed to inhibit Galphas protein function reduced parasitemia in P. falciparum cultures in vitro, and beta-antagonists reduced parasitemia of P. berghei infections in an in vivo mouse model. Thus, signaling via the erythrocyte beta2-adrenergic receptor and Galphas may regulate malarial infection across parasite species.  相似文献   

Amygdala response to happy faces as a function of extraversion     

Canli T  Sivers H  Whitfield SL  Gotlib IH  Gabrieli JD 《Science (New York, N.Y.)》2002,296(5576):2191

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Ecology: managing evolving fish stocks     

Jørgensen C  Enberg K  Dunlop ES  Arlinghaus R  Boukal DS  Brander K  Ernande B  Gardmark A  Johnston F  Matsumura S  Pardoe H  Raab K  Silva A  Vainikka A  Dieckmann U  Heino M  Rijnsdorp AD 《Science (New York, N.Y.)》2007,318(5854):1247-1248

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Aneuploidy drives genomic instability in yeast     

Sheltzer JM  Blank HM  Pfau SJ  Tange Y  George BM  Humpton TJ  Brito IL  Hiraoka Y  Niwa O  Amon A 《Science (New York, N.Y.)》2011,333(6045):1026-1030

Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombination, as well as defective DNA damage repair. Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.  相似文献   

Incorporating free-flowing rivers into global biodiversity targets: Prioritization and targeted interventions to maintain ecological integrity     

Chantel R. Petersen  Heidi van Deventer  Lindie B. Smith-Adao  Jeanne L. Nel 《水产资源保护:海洋与淡水生态系统》2023,33(1):115-128

1. Free-flowing rivers (FFRs) are important surrogates for freshwater biodiversity as there are increasingly fewer rivers that reflect intact habitat and species diversity from source to sea. The status and changes in the ecological condition or protection of FFRs is not explicitly reported on in global biodiversity targets. Indices are proposed for reporting such changes to the Sustainable Development Goals (SDGs) 6 and 15, Aichi Target 11, and the post-2020 global biodiversity framework.
2. FFRs were identified at a countrywide scale in South Africa for protection, planning, monitoring, and assessing changes in their ecological condition and protection status. They were selected and prioritized using criteria co-produced with national, provincial, and local river managers and policy makers. Given the high competition for water resources and the unlikely possibility for strictly protecting all FFRs, a subset of FFRs, termed ‘flagship FFRs’, was identified.
3. Methods for reporting changes in the protection levels of prioritized FFRs at a countrywide scale were developed, which included indices of FFRs related to global targets: the loss of the extent of FFRs in a natural and largely natural ecological condition for SDG 6; changes in the connectivity of FFRs included in the post-2020 global biodiversity framework targets; and changes in protection levels of FFRs for Aichi Target 11 and SDG 15.1.2.
4. Flagship FFRs attracted targeted management initiatives and thus maintained their connectivity and ecological condition. This was not true when all FFRs were considered; in the broader set of FFRs, longitudinal fragmentation increased and ecological condition declined from 2011 to 2018.
5. Considering the increasing pressures rivers are likely to experience from human and climate change impacts, particularly in semi-arid to temperate environments, urgent prioritization and monitoring of FFRs is called for so that a targeted set of protection and management strategies can be applied.

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