Effects of carprofen on renal function and results of serum biochemical and hematologic analyses in anesthetized dogs that had low blood pressure during anesthesia     

Boström IM  Nyman GC  Lord PE  Häggström J  Jones BE  Bohlin HP 《American journal of veterinary research》2002,63(5):712-721

OBJECTIVE: To investigate effects of IV administered carprofen on indices of renal function and results of serum biochemical and hematologic analyses in dogs anesthetized with acepromazine-thiopentone-isoflurane that had low blood pressure during anesthesia. ANIMALS: 6 healthy Beagles. PROCEDURE: A randomized crossover study was conducted, using the following treatments: saline (0.9% NaCl solution)-saline, saline-carprofen, and carprofen-saline. Saline (0.08 ml/kg) and carprofen (4 mg/kg) were administered IV. The first treatment was administered 30 minutes before induction of anesthesia and immediately before administration of acepromazine (0.1 mg/kg, IM). Anesthesia was induced with thiopentone (25 mg/ml, IV) and maintained with inspired isoflurane (2% in oxygen). The second treatment was administered 30 minutes after onset of inhalation anesthesia. Blood gases, circulation, and ventilation were monitored. Renal function was assessed by glomerular filtration rate (GFR), using scintigraphy, serum biochemical analyses, and urinalysis. Hematologic analysis was performed. Statistical analysis was conducted, using ANOVA or Friedman ANOVA. RESULTS: Values did not differ significantly among the 3 treatments. For all treatments, sedation and anesthesia caused changes in results of serum biochemical and hematologic analyses, a decrease in mean arterial blood pressure to 65 mm Hg, an increase of 115 pmol/L in angiotensin II concentration, and an increase of 100 seconds in time required to reach maximum activity counts during scintigraphy. CONCLUSIONS AND CLINICAL RELEVANCE: Carprofen administered IV before or during anesthesia did not cause detectable significant adverse effects on renal function or results of serum biochemical and hematologic analyses in healthy Beagles with low blood pressure during anesthesia.  相似文献   

Serum-haptoglobin concentration in Danish slaughter pigs of different health status     

Petersen HH  Ersbøll AK  Jensen CS  Nielsen JP 《Preventive veterinary medicine》2002,54(4):27-335

A cross-sectional study was conducted with 617 finishing pigs aged 10–25 weeks in 11 commercial herds of different health statuses as defined by the Danish monitoring program for specific-pathogen-free (SPF) herds. A standard clinical examination was performed and a blood sample was obtained from each pig for determination of haptoglobin concentration in serum.

Pigs aged 10–14, 15–19 and 20–25 weeks in conventional herds had higher haptoglobin concentrations than high-health SPF (SPF-x) pigs of the same age. There was no significant difference between SPF-x pigs of different ages. Conventional pigs aged 15–19 and 20–25 weeks had higher haptoglobin concentrations than conventional pigs aged 10–14 weeks. Herd influenced the haptoglobin concentration. Lame pigs and pigs with tail or ear bite had elevated haptoglobin concentrations. No significant effect of respiratory symptoms or umbilical hernia was found.  相似文献   

Risk factors for infection of sow herds with porcine reproductive and respiratory syndrome (PRRS) virus   总被引：10，自引：0，他引：10  

Mortensen S  Stryhn H  Søgaard R  Boklund A  Stärk KD  Christensen J  Willeberg P 《Preventive veterinary medicine》2002,53(1-2):83-101

In 1992, the porcine reproductive and respiratory syndrome virus (PRRSV) of European type (PRRSV-EU) was introduced in Denmark. By 1996, the virus had spread to approximately 25% of the Danish herds. In January 1996, a modified-live vaccine based on the American type of the virus (PRRSV-US) was used in replacement boars for Danish artificial insemination (AI) centres and from July 1996, the vaccine was used in PRRSV-EU infected herds for prevention of disease. Soon after vaccine introduction, PRRSV non-infected herds experienced outbreaks of disease due to infection with PRRSV-US. In this study, we investigated the risk factors (biosecurity level, animals, exposure from PRRSV-US-infected neighbour herds, semen, herd size, pig density and herd density) for infection with PRRSV-US in a cohort of 1071 sow herds; we used a nested case-control study. The retrospective observation period lasted from June 1996 (when they all were non-infected) to October 1997. Seventy-three non-vaccinated, closed sow herds became infected with the vaccine strain during this period. Each case herd was matched with two control herds from the cohort (controls had not been infected at the time of infection in the case herds). The data were analysed using a Cox-regression model. The hazard of infection increased significantly with exposure from PRRSV-US-infected neighbouring herds, purchase of animals from herds incubating PRRSV-US infection, increasing herd size and purchase of semen from boars at PRRSV-US-infected AI centres. The results are consistent with the modified-live vaccine strain spread to other herds by trade with animals and semen and by neighbour (area) transmission. We suggest that virus spread by aerosols was a frequent mode of transmission.  相似文献   

Penetration of amoxycillin to the respiratory tract tissues and secretions in Actinobacillus pleuropneumoniae infected pigs     

Henrik Agersø  Christian Friis  Jens Peter Nielsen 《Research in veterinary science》1998,64(3):251

The pharmokinetic properties of amoxycillin, and its penetration into respiratory tract tissue, were determined in 18 Actinobacillus pleuropneumoniae infected pigs, after a single i.v. dose of 8·6 mg amoxycillin kg⁻¹ bodyweight. Pleuropneumoniae was produced experimentally in pigs by an aerosol infection model. The infection created a homogenous response, characterised by depression of breathing and increased body temperature. The clinical symptoms were accompanied by increased haptoglobin levels and circulating white blood cell counts. At necropsy the findings were characterised by a bilateral fibrinous pleuropneumonia. Twenty hours after infection, the pigs were administered amoxycillin i.v. The plasma concentration-time curve was described by a three compartment open model. The mean residence time and the elimination half-life were l·5 and 3·4 hours, respectively. The steady-state volume of distribution was 0·67 litres kgl, and the clearance was 0·46 litres kg⁻¹ hour⁻¹. There were no significant differences between these values and those reported previously for healthy pigs. The concentration of amoxycillin in bronchial secretions, lung tissue and diseased lung tissue peaked two hours after intravenous drug administration, while amoxycillin concentration in pleural fluid, lymph nodes and tonsil tissue peaked at the first sampling point one hour after drug administration. The concentration of amoxycillin in secretions and tissue decreased by a slower rate than amoxycillin concentration in plasma, resulting in an increasing tissue-to-plasma concentration ratio. The distribution ratios (AUC_tissue/JAUC_plasma) was 0·53 for bronchial secretions, 0·44 for pneumonic lung tissue, 0·42 for lung tissue, 1·04 for pleural fluid, 0·58 for lymph nodes and 0·37 for tonsil tissue. The distribution of amoxycillin to secretions was increased compared with that previously reported for healthy pigs, while only minor changes were observed in lung tissue.  相似文献   

Description of empirical movement data from Canadian swine herds with an application to a disease spread simulation model     

Christensen J  McNab B  Stryhn H  Dohoo I  Hurnik D  Kellar J 《Preventive veterinary medicine》2008,83(2):170-185

We report the methods and findings of a survey of Canadian swine producers summarizing farm-types at-risk of foreign animal disease (FAD) and the routine movement of animals, semen and workers among swine farms, as observed during a 42-day period. Of the 311 producers who returned completed questionnaires, 17% represented swine-herds with no swine or semen movement on or off the farm during the 42 days, 57% were sow herds or farrow-to-finish herds with limited movement onto the farm but movement off the farm, and 26% were swine-herds with movements on and off the farm. A substantial number of premises (>50% in some provinces) with swine also kept other animal species on the same premises. We applied the empirical movement data from the survey in a stochastic simulation model to estimate the number of herds infected and the basic regional distribution of infection that could be expected to occur if the FAD was not detected and routine movements were permitted to occur up to 42 days after infection with a FAD of a single randomly selected herd. Forty-five percent of the simulations did not involve spread beyond the index farm, whereas 34.8% involved spread among five or more farms after 42 days of routine movement.  相似文献   

饲养策略调控肉质的研究进展     

韩立明  黄香文 《国外畜牧学(猪与禽)》2006,26(5):53-57

前言 从传统角度来看,"肉质"这个词涵盖了决定肉的适口性、深加工能力以及储存(包括零售展示)能力等性状的内在特性.人们主要关注肉的安全性、营养价值、风味、质地、系水力、色泽、脂肪含量及组成、氧化稳定性和质量均一性等.肉质被认为是肉品的一个复杂而多元的特性,主要受管理系统、品种、基因型、饲养、宰前处理、击晕方式、屠宰方法、冷却方法及储藏条件等多种因素相互作用的影响.  相似文献   

Mismanagement of fisheries: Policy or science?     

Massimiliano Cardinale  Henrik Svedng 《Fisheries Research》2008,93(1-2):244-247

Several gadoids stocks in the Northeast Atlantic are currently considered as severely overexploited. A fast spreading paradigm is that conventional single-species fisheries management has failed and new approaches are needed. A crucial element of this “novel way of thinking” is the cheered move from conventional single-species management to ‘ecosystem-based management’ in order to assure sustainability in the long term. Here we showed that although conducted within a deterministic single stock modelling framework, and without invoking the ecosystem approach, scientific advice if applied, mirrors in stocks being in relative healthy state. We argue that managers and politicians have had the necessary scientific instruments for managing stocks and avoid stock collapses, but they failed as they tried to minimize the impact of policy on those who are most affected (i.e. the fishing industry) in a short-term perspective. Thus, our results strengthen the hypothesis that it is the practise of ignoring the scientific advice more than the advice itself that is to be blamed for the waste of former large marine resources. What we urgently need for securing marine ecosystems is not more data but immediate actions.  相似文献   

Rapid and non-invasive measurements of fat and pigment concentrations in live and slaughtered Atlantic salmon (Salmo salar L.)     

Are Folkestad  Jens Petter Wold  Kjell-Arne Rrvik  Jon Tschudi  Karl Henrik Haugholt  Kari Kolstad  Turid Mrkre 《Aquaculture (Amsterdam, Netherlands)》2008,280(1-4):129-135

The aim of this study was to non-invasively determine fat and pigment concentrations in salmon muscle based on visible and near infrared (VIS/NIR) spectroscopy measurements of live/whole fish and fillets, and by means of digital photography (DP) of fillets. The fish used were two populations of farmed Atlantic salmon (Salmo salar L.) consisting of 46 salmon averaging 0.7 kg (range 0.17–1.7 kg, Group S) and 30 salmon averaging 2.3 kg (range 1.4–4.1 kg, Group L). Chemical analyses (fat and pigment content) and computerized tomography, CT (fat content) were used as reference methods. Group L was analysed in the live state (VIS/NIR), after gutting (VIS/NIR and CT), and as fillets (VIS/NIR and DP). Group S was analysed in the gutted state (VIS/NIR) and as fillets (VIS/NIR and DP). VIS spectroscopy predictions of pigment in whole salmon from Group S were obtained with a root mean square error of prediction (RMSEP) of 0.9 mg kg^− 1 astaxanthin, and a correlation between VIS spectroscopy predicted and chemically measured pigment of r = 0.85 (p < 0.0001). The fat concentration was determined by the NIR spectroscopy in live fish with RMSEP = 1.0 fat% unit, and a correlation with chemical reference values of r = 0.94 (p < 0.0001). Fat predictions from NIR spectroscopy correlated also well with predictions from CT analyses, r = 0.95 (p < 0.0001). VIS spectroscopy and DP were equally well suited to determine pigment concentrations in salmon fillets, with prediction errors of only 0.4 mg kg^− 1 astaxanthin, and a correlation with chemically determined pigment of r = 0.92 (p < 0.0001). The results obtained in the present study are the first to demonstrate successful non-invasive pigment predictions in whole salmon using VIS/NIR spectroscopy, and the possibility for simultaneous, rapid and non-destructive quantification of fat and pigment concentrations.  相似文献   

Canopy reflectance, thermal stress, and apparent soil electrical conductivity as predictors of within-field variability in grain yield and grain protein of malting barley   总被引：1，自引：0，他引：1  

Carl-Göran Pettersson  Mats Söderström  Henrik Eckersten 《Precision Agriculture》2006,7(5):343-359

Three consecutive crops of malting barley grown during 2002–2004 on clay-loam on a Swedish farm (59°74’ N, 17°00’ E) were monitored for canopy reflectance at growth stages GS32 (second node detectable) and GS69 (anthesis complete), and the crops were sampled for above ground dry matter and nitrogen content. GPS-positioned unfertilised plots were established and used for soil sampling. At harvest, plots of 0.25 m² were cut in both fertilised and unfertilised plots, and 24 m² areas were also harvested from fertilised barley. The correlations between nine different vegetation indices (VIs) from each growth stage and yield and grain protein were tested. All indices were significantly correlated (at 5% level) with grain yield (GY), and protein when sampled at GS69 but only four when sampled at GS32. Three variables (the best-correlated vegetation index sampled at GS32; an index for accumulated elevated daily maximum temperatures for the grain filling period, and normalised apparent electrical conductivity (ECa) of the soil) were sufficient input in the final regressions. Using these three variables, it was possible to make either one multivariate (PLS) regression model or two linear multiple regression models for grain yield (GY) and grain protein, with correlation coefficients of 0.90 and 0.73 for yield and protein, respectively.  相似文献   

Water distribution and microstructure in enhanced pork     

Bertram HC  Meyer RL  Wu Z  Zhou X  Andersen HJ 《Journal of agricultural and food chemistry》2008,56(16):7201-7207

Water characteristics and meat microstructure of NaHCO3-enhanced pork were compared with NaCl- and Na4O7P2-enhanced pork using low-field proton NMR relaxometry, advanced microscopy techniques, and traditional meat quality measurements. Porcine samples were enhanced at 4 degrees C for 48 h with sodium salts individually and in the following combinations: (i) 5% NaCl, (ii) 5% Na4O7P2, (iii) 3% NaHCO3, (iv) 5% NaCl and 5% Na4O7P2, (v) 5% NaCl and 3% NaHCO3, (vi) 5% Na4O7P2 and 3% NaHCO3, and (vii) 5% NaCl, 5% Na4O7P2, and 3% NaHCO3. Independently of the marinade used, the water-binding capacity was improved, cooking loss was reduced, and the yield was enhanced compared with nonmarinated pork samples. This was also reflected in the water mobility within the samples measured by proton NMR relaxometry. Visualization of samples by confocal laser scanning microscopy (CLSM) revealed salt-dependent microstructural changes in the green pork samples treated with NaHCO3, giving rise to nearly complete disintegration of overall structures. High-resolution visualization by atomic force microscopy (AFM) further suggested that a higher cooking loss in sodium chloride-enhanced samples could be ascribed to less solubilization and higher heat-induced protein denaturation compared with phosphate- and bicarbonate-enhanced samples.  相似文献