Description of empirical movement data from Canadian swine herds with an application to a disease spread simulation model     

Christensen J  McNab B  Stryhn H  Dohoo I  Hurnik D  Kellar J 《Preventive veterinary medicine》2008,83(2):170-185

We report the methods and findings of a survey of Canadian swine producers summarizing farm-types at-risk of foreign animal disease (FAD) and the routine movement of animals, semen and workers among swine farms, as observed during a 42-day period. Of the 311 producers who returned completed questionnaires, 17% represented swine-herds with no swine or semen movement on or off the farm during the 42 days, 57% were sow herds or farrow-to-finish herds with limited movement onto the farm but movement off the farm, and 26% were swine-herds with movements on and off the farm. A substantial number of premises (>50% in some provinces) with swine also kept other animal species on the same premises. We applied the empirical movement data from the survey in a stochastic simulation model to estimate the number of herds infected and the basic regional distribution of infection that could be expected to occur if the FAD was not detected and routine movements were permitted to occur up to 42 days after infection with a FAD of a single randomly selected herd. Forty-five percent of the simulations did not involve spread beyond the index farm, whereas 34.8% involved spread among five or more farms after 42 days of routine movement.  相似文献   

Bone tumors in a population of 400 000 insured Swedish dogs up to 10 y of age: incidence and survival   总被引：1，自引：0，他引：1       下载免费PDF全文

Agneta Egenvall  Ane Ndtvedt    Henrik von Euler 《Canadian journal of veterinary research》2007,71(4):292-299

The objectives of this study were to describe the incidence of, survival until, and survival after the diagnosis of canine bone tumors by breed, sex, age, and geographic location of residence. Dogs under 10 y old and insured by a Swedish insurance company between 1995 and 2002 were studied. In total, 764 dogs had claims for bone tumors, and the incidence rate was 5.5 cases per 10 000 dog-years at risk (DYAR). At ages 6, 8, and 10 y, the proportions of dogs with bone tumors were 0.13%, 0.30%, and 0.64%. The top 3 breeds at risk were Irish wolfhound, St. Bernard, and leonberger (incidence rates 99, 78, and 53 cases per 10 000 DYAR, respectively). Median survival time after diagnosis was 56 d in the 419 dogs that survived > or = 1 d. With a Cox regression model controlling for breed and age, females were shown to be at decreased risk of bone tumors, with a hazard ratio of 0.71 (99% confidence interval 0.58 to 0.87).  相似文献   

Intra-unit correlations in seroconversion to Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae at different levels in Danish multi-site pig production facilities     

Vigre H  Dohoo IR  Stryhn H  Busch ME 《Preventive veterinary medicine》2004,63(1-2):9-28

In this paper, multilevel logistic models which take into account the multilevel structure of multi-site pig production were used to estimate the variances between pigs produced in Danish multi-site pig production facilities regarding seroconversion to Actinobacillus pleuropneumoniae serotype 2 (Ap2) and Mycoplasma hyopneumoniae (Mh). Based on the estimated variances, three newly described computational methods (model linearisation, simulation and linear modelling) and the standard method (latent-variable approach) were used to estimate the correlations (intra-class correlation components, ICCs) between pigs in the same production unit regarding seroconversion. Substantially different values of ICCs were obtained from the four methods. However, ICCs obtained by the simulation and the model linearisation were quite consistent. Data used for estimation were collected from 1161 pigs from 429 litters reared in 36 batches at six Danish multi-site farms chronically infected with the agents. At the farms, weaning age was 3-4.5 weeks, after which batches of pigs were reared using all-in/all-out management by room. Blood samples were collected shortly before: weaning, transfer from weaning-site to finishing-site, and sending the first pigs in the batch for slaughter (third sampling). Few pigs seroconverted at the weaning-sites, whereas considerable variation in seroconversion was observed at the finishing-sites. Multilevel logistic models (initially including four levels: farm, batch, litter, pig) were used to decompose the variation in seroconversion at the finishing-site. However, there was essentially no clustering at the litter level-leading to the use of three-level models. In the case of Ap2, clustering within batch was so high that the data eventually were reduced to two levels (farm, batch). For seroconversion to Ap2, ICC between pigs within batches was approximately 90%, whereas the ICC between pigs within batches for Mh was approximately 40%. This indicates that the possibility for Mh to spread between pigs within batches is lower than for Ap2. The diversity in seroconversion between batches within the same farm was large for Ap2 (ICC approximately 10%), whereas there was a relative strongly ICC (approximately 50%) between batches for Mh. This indicates that the transmission of Mh is more consistent within a farm, whereas the presence of Ap2 varies between batches within a farm.  相似文献   

Application of acute phase protein measurements in veterinary clinical chemistry   总被引：1，自引：0，他引：1  

Petersen HH  Nielsen JP  Heegaard PM 《Veterinary research》2004,35(2):163-187

The body's early defence in response to trauma, inflammation or infection, the acute phase response, is a complex set of systemic reactions seen shortly after exposure to a triggering event. One of the many components is an acute phase protein response in which increased hepatic synthesis leads to increased serum concentration of positive acute phase proteins. The serum concentration of these acute phase proteins returns to base levels when the triggering factor is no longer present. This paper provides a review of the acute phase proteins haptoglobin, C-reactive protein and serum amyloid A and their possible use as non-specific indicators of health in large animal veterinary medicine such as in the health status surveillance of pigs at the herd level, for the detection of mastitis in dairy cattle and for the prognosis of respiratory diseases in horses.  相似文献   

Assessing tree dendrometrics in young regenerating plantations using terrestrial laser scanning     

Ying Li  Carsten Hess  Henrik von Wehrden  Werner Härdtle  Goddert von Oheimb 《Annals of Forest Science》2014,71(4):453-462

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The distribution pattern of Halicephalobus gingivalis in a horse is suggestive of a haematogenous spread of the nematode     

Christina Henneke  Anna Jespersen  Stine Jacobsen  Martin K Nielsen  Fintan McEvoy  Henrik E Jensen 《Acta veterinaria Scandinavica》2014,56(1)

The majority of Halicephalobus gingivalis-infections in horses have been fatal and are usually not diagnosed before necropsy. Therefore, knowledge about the nematode and the pathogenesis of infection in horses is limited. This has resulted in an on-going discussion about the port of entry and subsequent dissemination of H. gingivalis within the host. The present case of H. gingivalis-infection in a horse was diagnosed ante mortem. Post mortem findings, the distribution pattern of H. gingivalis nematodes in the brain, a high prevalence of inflammation in close relation to blood vessels, and the presence of the nematode in multiple organs with a disseminated pattern of distribution strongly suggested a haematogenous spread of the nematode in the horse.  相似文献   

A hereditary disposition for bovine peripheral nerve sheath tumors in Danish Holstein cattle     

Anette B Grossi  J?rgen S Agerholm  Knud Christensen  Henrik E Jensen  Páll S Leifsson  Christian Bendixen  Peter Karlskov-Mortensen  Merete Fredholm 《Acta veterinaria Scandinavica》2014,56(1)

Background

Peripheral nerve sheath tumors (PNSTs) are frequently found in Danish cattle at slaughter. Bovine PNSTs share several gross and histopathological characteristics with the PNSTs in humans with heritable neurofibromatosis syndromes. The aim of the present study was to investigate a possible hereditary disposition to PNSTs in dairy cattle by statistical analysis performed on data from 567 cattle with PNSTs. Furthermore, a preliminary genome-wide association study (GWAS) was performed on DNA isolated from 28 affected and 28 non-affected Holstein cows to identify loci in the bovine genome involved in the development of PNSTs.

Results

PNSTs were significantly more common in the Danish Holstein breed than in other breeds with 0.49% of Danish Holsteins slaughtered during an eight-year-period having PNSTs. PNSTs also occurred significantly more frequently in the offspring of some specific Holstein sires. Examination of three generation pedigrees showed that these sires were genetically related through a widely used US Holstein sire. The PNSTs included in GWAS were histologically classified as neurofibroma-schwannoma (43%), schwannoma (36%) and neurofibroma (21%) and derived from Holstein cows with multiple PNSTs. A single SNP on chromosome 27 reached genome-wide significance.

Conclusions

Gross and histological characteristics of bovine PNSTs are comparable to PNSTs in humans (schwannomatosis). Danish Holsteins are genetically disposed to develop PNSTs but the examined materials are insufficient to allow determination of the mode of inheritance.  相似文献   

Canopy reflectance, thermal stress, and apparent soil electrical conductivity as predictors of within-field variability in grain yield and grain protein of malting barley   总被引：1，自引：0，他引：1  

Carl-Göran Pettersson  Mats Söderström  Henrik Eckersten 《Precision Agriculture》2006,7(5):343-359

Three consecutive crops of malting barley grown during 2002–2004 on clay-loam on a Swedish farm (59°74’ N, 17°00’ E) were monitored for canopy reflectance at growth stages GS32 (second node detectable) and GS69 (anthesis complete), and the crops were sampled for above ground dry matter and nitrogen content. GPS-positioned unfertilised plots were established and used for soil sampling. At harvest, plots of 0.25 m² were cut in both fertilised and unfertilised plots, and 24 m² areas were also harvested from fertilised barley. The correlations between nine different vegetation indices (VIs) from each growth stage and yield and grain protein were tested. All indices were significantly correlated (at 5% level) with grain yield (GY), and protein when sampled at GS69 but only four when sampled at GS32. Three variables (the best-correlated vegetation index sampled at GS32; an index for accumulated elevated daily maximum temperatures for the grain filling period, and normalised apparent electrical conductivity (ECa) of the soil) were sufficient input in the final regressions. Using these three variables, it was possible to make either one multivariate (PLS) regression model or two linear multiple regression models for grain yield (GY) and grain protein, with correlation coefficients of 0.90 and 0.73 for yield and protein, respectively.  相似文献   

Ongoing modification of Mediterranean Pleistocene sapropels mediated by prokaryotes   总被引：2，自引：0，他引：2  

Coolen MJ  Cypionka H  Sass AM  Sass H  Overmann J 《Science (New York, N.Y.)》2002,296(5577):2407-2410

Late Pleistocene organic-rich sediments (sapropels) from the eastern Mediterranean Sea harbor unknown, metabolically active chemoorganotrophic prokaryotes. As compared to the carbon-lean intermediate layers, sapropels exhibit elevated cell numbers, increased activities of hydrolytic exoenzymes, and increased anaerobic glucose degradation rates, suggesting that microbial carbon substrates originate from sapropel layers up to 217,000 years old. 16S ribosomal RNA gene analyses revealed that as-yet-uncultured green nonsulfur bacteria constitute up to 70% of the total microbial biomass. Crenarchaeota constitute a smaller fraction (on average, 16%). A slow but significant turnover of glucose could be detected. Apparently, sapropels are still altered by the metabolic activity of green nonsulfur bacteria and crenarchaeota.  相似文献   

Pheromone signaling mechanisms in yeast: a prototypical sex machine     

Wang Y  Dohlman HG 《Science (New York, N.Y.)》2004,306(5701):1508-1509

The actions of many extracellular stimuli are elicited by complexes of cell surface receptors, heterotrimeric guanine nucleotide-binding proteins (G proteins), and mitogen-activated protein (MAP) kinase complexes. Analysis of haploid yeast cells and their response to peptide mating pheromones has produced important advances in our understanding of G protein and MAP kinase signaling mechanisms. Many of the components, their interrelationships, and their regulators were first identified in yeast. Current analysis of the pheromone response pathway (see the Connections Maps at Science's Signal Transduction Knowledge Environment) will benefit from new and powerful genomic, proteomic, and computational approaches that will likely reveal additional general principles that are applicable to more complex organisms.  相似文献