疑似碘酊致牛死亡一例     

何国新  刘金杰 《中国兽药杂志》2005,39(10):53-53

笔者在临床上曾遇到一疑似“碘酊”致牛死亡的病例,由于未曾见过碘酊致牛死亡的报道,查阅资料也终未得到答案.笔者将其整理如下,供同行探讨。  相似文献   

Control measures for contagious enteric diseases in a veterinary teaching hospital          下载免费PDF全文

Ravary B  Fecteau G  Higgins R  Paré J  Lavoie JP 《The Canadian veterinary journal. La revue veterinaire canadienne》1999,40(12):871-877

Instructions and control measures related to enteric contagious diseases at the Veterinary Medical Teaching Hospital (VMTH) of the Faculty of Veterinary Medicine of the University of Montreal are presented. These control measures, which have given satisfactory results within the past decade, are exemplified by a salmonellosis outbreak that occurred in spring 1996 in the large animal clinic of the VMTH. Emphasis was put on the importance of antigenic and/or genetic characterizations of Salmonella isolates, in order to detect an eventual source of contamination, but also to determine the incidence of nosocomial infections among hospitalized animals.  相似文献   

Swine leptospirosis: low risk of exposure for humans?          下载免费PDF全文

Ribotta M  Higgins R  Perron D 《The Canadian veterinary journal. La revue veterinaire canadienne》1999,40(11):809-810

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Actions of betamethasone in models of acute non-immune inflammation     

P Lees  A J Higgins  A D Sedgwick  M J Daniel 《The British veterinary journal》1987,143(2):143-158

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The Pathogenesis of Infectious Disease          下载免费PDF全文

R. Higgins 《The Canadian veterinary journal. La revue veterinaire canadienne》1978,19(2):47-48

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The pathogenesis of leptospirosis I. Hemorrhages in experimental leptospirosis in guinea pigs.   总被引：7，自引：2，他引：5       下载免费PDF全文

R Higgins  G Cousineau 《Canadian journal of veterinary research》1977,41(2):174-181

In experimental infections of guinea pigs with a virulent strain of Leptospira icterohaemorrhagiae widespread hemorrhages were observed. Thrombocytopenia, prolongation of prothrombin, thrombin, partial thromboplastin and coagulation times, decrease of plasma fibrinogen, factor V, factor VIII and the presence of fibrinogen degradation products were demonstrated. Treatment of infected guinea pigs with heparin prolonged life for two to three days. The histological observations revealed that the main lesion is a severe injury of the vasculature, mainly arteries, arterioles and capillaries. Most of the endothelial cells are affected or destroyed and the muscular fibers of arteries and arterioles are injured. With Martius-Scarlet-Blue, Weigert or Picro-Mallory stains it was demonstrated that the organization seen in the vessels is not all made of fibrin. The conclusion reached was that the hemorrhages observed in experimental leptospirosis in guines pigs are due to disseminated intravascular coagulation.  相似文献   

Evolution of bacterial resistance to certain antibacterial agents in horses in a veterinary hospital          下载免费PDF全文

Peyrou M  Higgins R  Lavoie JP 《The Canadian veterinary journal. La revue veterinaire canadienne》2003,44(12):978-981

Evolution of bacterial resistance to certain antibacterial agents in horses in a veterinary hospital. A total of 255 antibiograms, conducted according to the Kirby-Bauer method from bacterial isolates collected from horses at the H?pital Vétérinaire d'Enseignement at the Université de Montréal between 1996 and 1998 were compared with the results obtained about 10 years ago with corresponding bacterial species. A significant increase in the percentage of strains resistant to trimethoprim-sulfamethoxazole (TMP-SXT), penicilline, tetracycline, and to gentamicin was observed. The percentages of isolates of Actinobacillus spp. and coagulase-positive staphylococci resistant to TMP-SXT increased from 0% to 17% and from 0% to 33%, respectively, (P < 0.05). The percentage of isolates of Actinobacillus spp resistant to penicilline also increased from 33% to 73% (P < 0.05). Regular monitoring of the evolution of bacterial resistance to antibacterial agents is indispensable in a hospital structure. The adoption of "good antibiotherapy practices" is essential to guarantee a decrease in the risks of selection and dissemination of a resistant bacterial strain.  相似文献   

16alpha-Bromo-epiandrosterone therapy modulates experimental feline immunodeficiency virus viremia: initial enhancement leading to long-term suppression     

Pedersen NC  North TW  Rigg R  Reading C  Higgins J  Leutenegger C  Henderson GL 《Veterinary immunology and immunopathology》2003,94(3-4):133-148

16alpha-Bromo-epiandrosterone (epiBr), a synthetic derivative of the natural hormone dehyroepiandrosterone (DHEA), was evaluated for its effects on feline immunodeficiency virus (FIV) infection in experimental cats. The rationale for this study was based on the ability of DHEA to significantly reduce the mortality to viral infections in mice. DHEA and epiBr also have demonstrable in vitro anti-viral activity for both HIV-1 and FIV. Preliminary pharmacokinetic studies in cats demonstrated that subcutaneously injected epiBr was rapidly absorbed, completely metabolized, and nontoxic. Metabolites were excreted in both urine and feces, with the latter having the most complex pattern of breakdown products. Cats were then divided into four groups; two groups were infected with FIV and two uninfected. Two groups, one infected and one uninfected were treated on 5 consecutive days of weeks 0, 4, 8, 12 and 16 with epiBr. The remaining two groups were mock treated with the drug vehicle alone. Treatment started 1 week prior to infection and extended for 4 weeks after infection. Cats were observed for 20 weeks post-FIV infection. Infected cats had identical decreases in blood neutrophil and lymphocyte counts following, regardless of whether they were treated with epiBr or vehicle alone. The CD4/CD8 T-cell ratio was decreased following FIV exposure, but was significantly more decreased for the epiBr treated animals from week 2 post-infection onward. CD4+ T cells were decreased in FIV-infected cats treated with epiBr compared to their untreated cohort, while CD8+ T cells tended to be higher in treated animals. FIV infected cats that were treated with epiBr had over one-log higher virus loads at week 2 post-infection than non-epiBr treated cohorts. In spite of this enhanced initial viremia, the subsequent levels of virus in the blood were significantly lower in epiBr treated versus untreated animals. EpiBr treated cats had significantly higher FIV-p24 antibody responses than control cats receiving vehicle alone, although primary and secondary antibody responses to a T-cell dependent non-FIV antigen, keyhole limpet hemocyanin (KLH), were unaffected. EpiBr treatment significantly decreased the expected FIV-induced suppression of IL-12 p40 mRNA levels in peripheral blood mononuclear cells (PBMCs) observed at weeks 4, 5, 8, 9 and 16 post-infection, but had no influence on FIV-induced changes in IL-4, IL-6, IL-10, IFN-gamma, MIP-1alpha and RANTES.  相似文献   

Effects of Ascophyllum nodosum extract on growth performance and immune function of young pigs challenged with Salmonella typhimurium     

Turner JL  Dritz SS  Higgins JJ  Minton JE 《Journal of animal science》2002,80(7):1947-1953

Ninety-five pigs (initially 7.1 kg and 24 d of age) were used in a 28-d experiment to determine the effects of Ascophyllum nodosum seaweed extract (ANOD) on young pig growth performance and immune function in response to enteric disease challenge with Salmonella typhimurium (ST). Experimental treatments were arranged in a 2 x 4 factorial with main effects of disease challenge (control vs ST-challenge) and dietary addition of ANOD (0, 0.5, 1.0, and 2.0% of diet). Pigs were fed ANOD diets for 14 d and then challenged orally with ST or sterile media. There were no main effects of ANOD on growth performance end points, although there were significant quadratic effects of ANOD on ADG (P < 0.04) and final weight (P < 0.003), both being greatest at 1.0% ANOD. There was a positive linear effect of ANOD inclusion on ADFI (P < 0.07) and a negative linear effect on the gain-to-feed ratio (G/F) (P < 0.05). ST-challenge reduced ADG (P < 0.05), ADFI (P < 0.05), and G/F (P < 0.05) in the first week following challenge. Daily estimates revealed reductions in feed intake in ST-infected pigs on d 2 to 4 following infection (P < 0.05). Rectal temperature was increased maximally 2 d following ST-infection (P < 0.05). A disease challenge x time interaction (P < 0.001) was observed for serum haptoglobin and alpha1-acid glycoprotein. Serum immunoglobulin M (IgM) was not influenced by disease challenge, but IgM declined (P < 0.001) in all pigs over time. Serum immunoglobulin G (IgG) also was not influenced by disease challenge, but IgG tended (P < 0.08) to increase over time. In vitro culture of porcine alveolar macrophages with 10 mg/mL ANOD elevated (P < 0.05) prostaglandin E2 (PGE2) production over that of controls at 3 and 24 h of culture. There was no interleukin-10 response by porcine splenocytes cultured in vitro with 0.005, 0.05, 0.5, or 5 mg/mL ANOD. We conclude that this model of enteric disease elicits an acute phase response that is accompanied by increased rectal temperature and diminished feed intake. Furthermore, our results indicate some beneficial effects of dietary ANOD on growth performance and no influence of dietary ANOD on immune response in the presence or absence of ST-challenge. However, high ANOD concentrations are capable of activating porcine alveolar macrophages in vitro to secrete PGE2.  相似文献   

Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter     

Drolet R  D'Allaire S  Larochelle R  Magar R  Ribotta M  Higgins R 《The Veterinary record》2002,150(5):139-143

One kidney was taken from each of 100 pigs at slaughter; 50 had gross lesions of multifocal interstitial nephritis and 50 had no gross lesions. Forty-nine of the affected kidneys had lesions that were characterised by the presence of either a few randomly distributed or numerous widely disseminated pale foci, 1 to 3 mm in diameter, on the cortical surface (white-dotted kidneys). Microscopically, these focal inflammatory lesions often had a distinct lymphofollicular pattern (follicular nephritis). Lesions of chronic vasculitis were observed in 21 of the affected kidneys. Histologically, the control kidneys had only small and sparse inflammatory foci. Standard bacterial cultures of kidneys of both groups were not significant, and cultures for the isolation of leptospires were all negative. Virological examination of the kidney homogenates by PCR did not reveal any porcine reproductive and respiratory syndrome virus and only a few cases were positive for the porcine circovirus type 1. However, porcine parvovirus (PPV) and porcine circovirus type 2 (PCV-2) were detected in many kidneys of both groups but in a significantly higher proportion of the kidneys with interstitial nephritis. There was a significant association between the lesions and the presence of PPV and PCV-2 with odds ratios of 7.5 (P<0.0001) and 3.4 (P=0.0074), respectively, and the odds ratio increased to 22.7 (P<0.0001) when both viruses were identified in the same kidney. However, a subsample of kidneys taken from both groups were negative by immunohistochemistry for the presence of PPV and PCV-2 antigens.  相似文献