Effect of levamisole on the clinical and immunologic responses to oral vaccine of Treponema hyodysenteriae     

E M Jenkins  S Nash  W Hill  J Mosley 《American journal of veterinary research》1987,48(4):657-660

Conventionally raised crossbred Hampshire pigs were vaccinated orally with attenuated Treponema hyodysenteriae in combination with an anthelmintic, levamisole or dichlorvos. Pigs in group I (n = 9) were treated with levamisole and vaccinated with attenuated T hyodysenteriae and those in group II (n = 9) were treated with levamisole and permitted to commingle (contact exposure) with group I. Pigs in group III (n = 9) were vaccinated in a similar manner and were treated with dichlorvos. Pigs in group IV (n = 9) were treated with dichlorvos and permitted to commingle with group III. Control pigs (group V; n = 9) were not given any anthelmintic, nor were they vaccinated; they were housed separately. During the 8-week interval between vaccination and challenge inoculation, 4 total days and 8 total days of diarrhea were observed in pigs in groups I and II, respectively. Likewise, 5 total days and 10 total days of diarrhea were seen in groups III and IV, respectively. In all groups, the pigs tended to shed the organism in their feces after they were vaccinated or challenge inoculated, as determined by a fluorescent antibody technique (FAT) and culture procedure (CP). Overall mean shedding patterns of 5.5% and 24.5% identified by CP and FAT, respectively, were seen in the 2 levamisole-treated groups (I and II). In contrast, mean shedding patterns of 4% and 18% of the isolation attempts were detected by CP and FAT, respectively, in the 2 dichlorvos-treated groups. Diarrhea and shedding of T hyodysenteriae in the controls (group V) did not occur.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

Comparative microscopic lesions in reoviral and staphylococcal tenosynovitis     

J E Hill  G N Rowland  J R Glisson  P Villegas 《Avian diseases》1989,33(3):401-410

Experimental inoculation of 1-day-old male broiler chickens with avian reo-virus or Staphylococcus aureus caused tenosynovitis of the gastrocnemius and digital flexor tendons. Reovirus inoculation by either the oral or footpad route initiated a diffuse lymphocytic infiltration in the peritendineum, synovial membrane, and epitenon from 1 to 5 weeks postinoculation (PI). Heterophils were not a predominant feature of the inflammatory response, but when present they were localized with fibrin in and around synovial spaces. The prevalence of microscopic tendon lesions was less common with staphylococcal infection than with reovirus infection. With staphylococcus, lesions were localized to the synovial space and membranes and were characterized by heterophils and fibrin but few lymphocytes. Synovial cell hyperplasia and bursal atrophy were common in both groups. From 10 to 20 weeks PI, both groups developed progressive tendon fibrosis. These results indicate that tenosynovitis due to inoculation with reovirus or staphylococcus may be differentiated histologically from 1 through 5 weeks PI. After 10 weeks, this may not be possible, because diffuse fibrosis was the major lesion with both. Perhaps fibrosis predisposes older, heavier broilers to tendon failure and rupture.  相似文献   

Malabsorption in dogs     

F W Hill 《The Veterinary record》1970,87(17):495-496

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The experimental transmission of various mycoplasmas of feline origin to domestic cats (Felis catus)   总被引：1，自引：0，他引：1  

D K Blackmore  A Hill 《The Journal of small animal practice》1973,14(1):7-13

Mycoplasma felis and M. gatae recovered from domestic cats, M. arginini from a cheetah, an unidentified glucose-fermenting mycoplasma from a lion, and M. pulmonis from a rat were inoculated into specific pathogen free (SPF) kittens by the oral, ocular and nasal routes. During the 21-day experimental period a persistent infection was established in a proportion of the kittens challenged with M. felis, M. gatae and M. arginini. The mycoplasma isolated from the lion created a transitory infection in one kitten, but M. pulmonis could not be recovered even 24 hr after inoculation. None of the organisms investigated showed any pathological effect. The implications of this work in relation to the host-specificity and pathogenicity of the feline mycoplasmas are discussed. Résumé. On a inoculé à des chatons axéniques par les voies orales, oculaires et nasales, un Myco-plasmafelis et un M. gatae recueillis de chats domestiques, un M. arginini recueilli d'un guépard, un mycoplasme non identifié à glucose fermentant recueilli d'un lion et un M. pulmonis recueilli d'un rat. Durant la période expérimentale de 21 jours, on a établi une infection persistante dans une proportion des chatons soumis aux tests de Mycoplasma felis, de M. gatae et de M. agrinini. Le mycoplasma isolé recueilli du lion a créé une infection transitoire chez un chaton, mais le M. pulmonis n'a pu être recueilli, même 24 heures après l'inoculation. Aucun des organismes sous investigation n'a montré d'effets pathologiques. On a discuté des implications de ce travail en relation avec la spécifité d'hôtes et la pathogénicité de mycoplasmes félins. Zusammenfassung. Mycoplasma felis und M. gatae von Hauskatzen erlangt, M. arginini von einem Tschita, ein unidentifiziertes Glukose-fermentierendes Mycoplasma von einem Löwen, und M. pulmonis von einer Ratte wurden in keimfreie (SPF) junge Katzen geimpft, auf oralem, Augen- und Nasenweg. Während der 21 tägigen Versuchsperiode wurde eine anhaltende Infektion in den Katzen festgestellt, die dem M. felis, M. gatae und dem M. agrinini ausgesetzt waren. Das Mycoplasma von dem Löwen abgesondert, verursachte eine vorübergehende Infektion eines Kätzchens, aber M. pulmonis konnte selbst 24 Stunden nach der Impfung nicht gefunden werden. Keines der untersuchten Organismen zeigte irgendwelche pathologischen Effekte. Die Folgerungen dieser Arbeit im Verhältnis zu der Gast-Spezifität und Pathogenizität des Katzen-mycoplasmas sind diskutiert.  相似文献   

An investigation of the effects of oral neomycin on intestinal absorption and serum cholesterol levels in the dog     

F W Hill 《The British veterinary journal》1973,129(4):337-344

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Clinical efficacy of benzathine cloxacillin in dry-cow mastitis treatment     

G N Hill  T J Keefe 《Modern veterinary practice》1974,55(11):843-4, 846

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TOXICITY OF PIMELEA DECORA IN HORSES     

M. W. M. Hill  B.V.Sc. 《Australian veterinary journal》1970,46(6):287-289

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Ultrastructure of the gastrocnemius tendon and sheath from broilers infected with reovirus     

J E Hill  G N Rowland  W L Steffens  M B Ard 《Avian diseases》1989,33(1):79-85

Gastrocnemius tendon and sheath from male broilers infected with reovirus at 1 day of age were evaluated ultrastructurally at 1, 2, 3, 4, 5, 10, 15, and 20 weeks postinoculation (PI). Although virus particles were not identified, degenerative changes in sheath and tendon fibroblasts were characterized by cytoplasmic vacuolization, disruption of membranes, and loss of ribosomes from rough endoplasmic reticulum, mitochondrial degeneration, and cell disruption.  相似文献   

Infection of pigs by aerosols of Aujeszky's disease virus and their shedding of the virus     

R. R. Gillespie  M. A. Hill 《Research in veterinary science》1996,60(3):228-233

On three consecutive days, six pigs were exposed for 15 minutes to aerosols of Aujeszky's disease virus. The total estimated dose was 4·5 log₁₀ 50. Within each isolation room, a sentinel pig was placed on a deck two feet away from the infected pig. The breath of the pigs that had inhaled the aerosols was collected on days 3, 7 and 13. The respiratory and other clinical signs of the infected pigs resembled those in field cases of Aujeszky's disease. All the pigs infected with Aujeszky's disease virus seroconverted within seven to 10 days after infection. Among the sentinel pigs, clinical signs were minimal and only three seroconverted.  相似文献   

Some causes of diarrhoea in the dog     

F W Hill  R H Penny 《The Journal of small animal practice》1973,14(4):195-203

The basic cause of diarrhoea is explained. The present high incidence of intestinal syndromes in dogs is mentioned and an analysis is given of the cases seen during a year at the University of Bristol Veterinary School. Some of the commoner clinical entities which give rise to diarrhoea are described. Résumé. On explique la cause basique de la diarrhée. On fait mention de l'incidence actuelle élevée de syndromes splanchniques chez les chiens et on donne une analyse des cas vus au cours d'une année à l'École Vétérinaire de l'Université de Bristol. On décrit quelques-unes des entités cliniques les plus communes qui provoquent une diarrhée. Zusammenfassung. Die Hauptursache für Durchfall wurde erklärt. Das augenblickliche hohe Vorkommen von viszeralen Syndromen in Hunden ist erwähnt und eine Analyse von Fällen die man ein Jahr lang in der tierärztlichen Schule der Universität Bristol behandelte, wurde ver-öffentlicht. Einige der gewöhnlicheren klinischen Entitäten die Durchfall verursachen, sind beschrieben.  相似文献