Fluphenazine induced Parkinson-like syndrome in a horse     

B D Brewer  M T Hines  J T Stewart  J F Langlois 《Equine veterinary journal》1990,22(2):136-137

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The human-animal bond in the public health curriculum     

W F McCulloch  N D Heidelbaugh  L M Hines  L K Bustad 《Journal of the American Veterinary Medical Association》1983,183(12):1414-1419

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Effects of trimethoprim-sulfadiazine on thyroid function of horses     

Rothschild CM  Hines MT  Breuhaus B  Gay J  Sellon DC 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2004,18(3):370-373

Trimethoprim-sulfadiazine was administered to horses in a randomized, placebo controlled study to determine the effects of potentiated sulfonamides on thyroid function in normal horses. The treatment group included eight horses that received trimethoprim-sulfadiazine mixed with molasses orally at 30 mg/kg once daily for eight weeks. The control group included 8 horses that received an oral placebo (flour mixed with molasses) once daily for the same period. Thyroid function was evaluated prior to initiation of treatment and after 8 weeks of treatment. Serum concentrations of total and free triiodothyronine (T3), total and free thyroxine (T4), and thyroid stimulating hormone (TSH) were determined at rest and after a thyrotropin-releasing hormone (TRH) stimulation test. There was no detectable difference between treatment and control groups.  相似文献   

B-cell conjunctival lymphoma in a cat     

Radi ZA  Miller DL  Hines ME 《Veterinary ophthalmology》2004,7(6):413-415

A bilateral conjunctival neoplasm was surgically removed from a 13-year-old Domestic Short-haired female cat and examined by histopathology. The neoplasm was infiltrative, nonencapsulated and composed of large sheets of densely packed, round to polygonal cells. Neoplastic cells were variably sized with scant to modest amounts of cytoplasm and oval to round nuclei. On immunohistochemistry the neoplastic cells stained positively for BLA.36 and negative for CD-3 antibodies. On the basis of histopathology and immunohistochemical findings, a diagnosis of conjunctival B-cell lymphoma was made. This is the first case with immunohistochemical characterization of conjunctival lymphoma in a cat.  相似文献   

Effect of daily administration of pyrantel tartrate in preventing infection in horses experimentally challenged with Sarcocystis neurona     

Rossano MG  Schott HC  Kaneene JB  Murphy AJ  Kruttlin EA  Hines MT  Sellon DC  Patterson JS  Elsheikha HM  Dubey JP  Mansfield LS 《American journal of veterinary research》2005,66(5):846-852

OBJECTIVE: To determine whether daily administration of pyrantel tartrate can prevent infection in horses experimentally challenged with Sarcocystis neurona. ANIMALS: 24 mixed-breed specific-pathogen-free weanling horses, 10 adult horses, 1 opossum, and 6 mice. PROCEDURE: Sarcocystis neurona-na?ve weanling horses were randomly allocated to 2 groups. Group A received pyrantel tartrate at the labeled dose, and group B received a nonmedicated pellet. Both groups were orally inoculated with 100 sporocysts/d for 28 days, 500 sporocysts/d for 28 days, and 1000 sporocysts/d for 56 days. Blood samples were collected weekly, and CSF was collected monthly. Ten seronegative adult horses were monitored as untreated, uninfected control animals. All serum and CSF samples were tested by use of western blot tests to detect antibodies against S. neurona. At the end of the study, the number of seropositive and CSF-positive horses in groups A and B were compared by use of the Fisher exact test. Time to seroconversion on the basis of treatment groups and sex of horses was compared in 2 univariable Cox proportional hazards models. RESULTS: After 134 days of sporocyst inoculation, no significant differences were found between groups A and B for results of western blot tests of serum or CSF There were no significant differences in number of days to seroconversion on the basis of treatment groups or sex of horses. The control horses remained seronegative. CONCLUSIONS AND CLINICAL RELEVANCE: Daily administration of pyrantel tartrate at the current labeled dose does not prevent S. neurona infection in horses.  相似文献   

THE TOXIC PROPERTIES OF SALVIA REFLEXA.     

C. H. Williams  B.Sc.  Dip. Pharm. H. J. G. Hines  B.Sc. 《Australian veterinary journal》1940,16(1):14-20

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Pharmacokinetics of butorphanol and evaluation of physiologic and behavioral effects after intravenous and intramuscular administration to neonatal foals     

Arguedas MG  Hines MT  Papich MG  Farnsworth KD  Sellon DC 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2008,22(6):1417-1426

Background: Despite frequent clinical use, information about the pharmacokinetics (PK), clinical effects, and safety of butorphanol in foals is not available. Objectives: The purpose of this study was to determine the PK of butorphanol in neonatal foals after IV and IM administration; to determine whether administration of butorphanol results in physiologic or behavioral changes in neonatal foals; and to describe adverse effects associated with its use in neonatal foals. Animals: Six healthy mixed breed pony foals between 3 and 12 days of age were used. Methods: In a 3‐way crossover design, foals received butorphanol (IV and IM, at 0.05 mg/kg) and IV saline (control group). Butorphanol concentrations were determined by high‐performance liquid chromatography and analyzed using a noncompartmental PK model. Physiologic data were obtained at specified intervals after drug administration. Pedometers were used to evaluate locomotor activity. Behavioral data were obtained using a 2‐hour real‐time video recording. Results: The terminal half‐life of butorphanol was 2.1 hours and C₀ was 33.2 ± 12.1 ng/mL after IV injection. For IM injection, C_max and T_max were 20.1 ± 3.5 ng/mL and 5.9 ± 2.1 minutes, respectively. Bioavailability was 66.1 ± 11.9%. There were minimal effects on vital signs. Foals that received butorphanol spent significantly more time nursing than control foals and appeared sedated. Conclusions and Clinical Importance: The disposition of butorphanol in neonatal foals differs from that in adult horses. The main behavioral effects after butorphanol administration to neonatal foals were sedation and increased feeding behavior.  相似文献   

Streptococcus equi Infections in Horses: Guidelines for Treatment,Control, and Prevention of Strangles—Revised Consensus Statement          下载免费PDF全文

A.G. Boyle  J.F. Timoney  J.R. Newton  M.T. Hines  A.S. Waller  B.R. Buchanan 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(2):633-647

This consensus statement update reflects our current published knowledge and opinion about clinical signs, pathogenesis, epidemiology, treatment, complications, and control of strangles. This updated statement emphasizes varying presentations in the context of existing underlying immunity and carrier states of strangles in the transmission of disease. The statement redefines the “gold standard” for detection of possible infection and reviews the new technologies available in polymerase chain reaction diagnosis and serology and their use in outbreak control and prevention. We reiterate the importance of judicious use of antibiotics in horses with strangles. This updated consensus statement reviews current vaccine technology and the importance of linking vaccination with currently advocated disease control and prevention programs to facilitate the eradication of endemic infections while safely maintaining herd immunity. Differentiation between immune responses to primary and repeated exposure of subclinically infected animals and responses induced by vaccination is also addressed.  相似文献   

Weed control and potato (Solanum tuberosum) tolerance with dimethenamid isomers and other herbicides     

Robert J. Richardson  Cory M. Whaley  Henry P. Wilson  Thomas E. Hines 《American Journal of Potato Research》2004,81(5):299-304

Two research studies were conducted to evaluate weed control in potato with dimethenamid and dimethenamid-p. No significant injury was observed from most applications of dimethenamid prior to potato emergence, but injury was 20% to 38% with dimethenamid when emerging potatoes were covered slightly by soil during “drag-off” and rain occurred within 24 h. Common lambsquarters (Chenopodium album L.) and common ragweed (Ambrosia artemisiifolia L.) control with dimethenamid preemergence (PRE) did not exceed 68%. Dimethenamid-p plus metribuzin or dimethenamid-p followed by (fb) rimsulfuron postemergence (POST) controlled common lambsquarters 95% to 96% and common ragweed 71% to 92%. Annual grass control was greater with S-metolachlor alone than with dimethenamid isomers alone. Broadleaf and grass control was similar with dimethenamid and dimethenamid-p.  相似文献   

Plant metabolism. Green pathways. Introduction     

Hines PJ  Zahn LM 《Science (New York, N.Y.)》2012,336(6089):1657

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