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排序方式: 共有105条查询结果,搜索用时 15 毫秒
81.
Ishikawa M Maeda H Kondo H Shibuya H Onuma M Sato T 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2007,69(11):1183-1185
A rare lymphoma that developed in the cecum of a domestic pet rabbit (6 years old, male, crossbred) was examined pathologically. The tumor consisted of proliferating neoplastic lymphoid cells, which were strongly stained with anti-CD79alpha monoclonal antibody. Electron microscopy revealed the tumor cells were composed of rough endoplasmic reticula and/or dilated rough endoplasmic reticula filled with moderately electron-dense material. These findings indicated the present case was rare digestive tract lymphoma originated from B-lymphocytic lineage in the cecum. 相似文献
82.
Junji Kimbara Akio Ohyama Hiroshi Chikano Hirotaka Ito Katsutoshi Hosoi Satomi Negoro Koji Miyatake Hirotaka Yamaguchi Tsukasa Nunome Hiroyuki Fukuoka Takeshi Hayashi 《Euphytica》2018,214(11):210
Fruit nutritional and flavor components are important targets for breeding new cultivars of tomato (Solanum lycopersicum L.). We developed 108 recombinant inbred lines (the K39 RILs) in the F6 generation from a cross between two phenotypically different breeding lines, K03 and K09. A linkage map was constructed using 172 genome-wide simple sequence repeat markers, 3 single-nucleotide polymorphism markers, and 2 phenotypic markers. The K39 RIL map consists of 12 linkage groups (LGs) and covers a genetic distance of 1089 cM. We measured the fruit soluble solids content (SSC), titratable acidity (TA), glutamic acid content (GLU), and lycopene content (LYC) of each line in four generations (F6, F8, F10, F11), β-carotene content (CAR) in two generations, and pH in one generation. By composite interval mapping that considered yearly variations in components as non-genetic effects, we detected three quantitative trait loci (QTLs) for SSC, four for TA, two for CAR, and one each for GLU, LYC, and pH. Among them, we found two QTLs for TA in LGs 6 and 11, those for GLU and LYC were candidates for novel QTLs. QTLs detected in this study were clustered in five LGs, but we observed no apparent trade-off relationships among the QTLs in each LG. Being derived from an intra-specific cross of tomato breeding materials, these QTLs can be used in practical breeding for improving fruit quality with low risk of linkage drag. 相似文献
83.
Hoshi H Iijima H Ishihara Y Yasuhara T Matsunaga K 《Journal of agricultural and food chemistry》2008,56(17):7715-7720
Alpha-D-glucan (MPG-1) separated from Tricholoma matsutake (CM6271) has been reported to show immunomodulatory activities. In this study, the plasma concentration and tissue distribution of MPG-1 after CM6271 oral administration were investigated as part of the action mechanism analysis. When CM6271 was orally administered in a single dose to mice, MPG-1 was absorbed via the intestinal tract, appeared in plasma after 16 h, was gradually excreted from the blood, and fell to background level after 48 h. The time course analysis of MPG-1 in plasma showed the following pharmacokinetic parameters of MPG-1: tmax = 24 h; Cmax = 161.1 ng/mL; AUC(0-infinity) = 2559.7 ng x h/mL. Moreover, MPG-1 was confirmed to localize in Peyer's patches, mesenteric lymph nodes (MLN), and the spleen and to promote IL-12 p70 production and NK cell activity. These results suggest that MPG-1 stimulated the intestinal immune system through Peyer's patches; moreover, it was taken into the blood and stimulated the systemic immune system. 相似文献
84.
Naka OKUMURA Iori KOIZUMI Yuki IWATA Shion YONEYA Ryota KOBA Hirotaka KONDO Hisashi SHIBUYA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(11):1726
Skin lesions possibly caused by Papillomavirus infections in two four-toed hedgehogs are described. In case 1, there was a papillary mass on the right hind limb. Histologically, the mass was consistent with a viral papilloma. In the other case, multifocal papillary masses with erosions and ulcers were found throughout the body, mainly on the extremities. Histology showed continuative lesions composed of acanthosis, Bowenoid in situ carcinoma, and squamous cell carcinoma, with abrupt transitions between the lesions. In both cases, keratinocytes in the granular layer infrequently had features of koilocytes and intranuclear inclusion bodies, and immunohistochemical staining was positive for anti-human papillomavirus antibody. To the best of the authors’ knowledge, this is the first pathological documentation of possibly papillomavirus-associated skin lesions in four-toed hedgehogs. 相似文献
85.
This study evaluates the influence of temperature manipulation on circulating levels of sex steroids and gonadal maturation in F1 generation Senegalese sole Solea senegalensis breeders kept under either continuous light (LL) or natural photoperiod (NP). Under LL, progressive water temperature reduction during early winter [treatment MT (modified temperature)] significantly elevated [compared with exposure to LL and constant temperature (CT)] plasma steroid levels in females (January–February) and males (January) and proportion of females initiating maturation (January), suggesting a modulatory role of decreasing temperature in the early phases of sole gonadal recrudescence. Under NP, treatment MT did not stimulate female gonadal maturation despite the significantly higher plasma testosterone levels (February) compared with exposure to NP and CT, which may indicate that females at early‐intermediate phases of ovarian development, the predominant stages of maturation at early winter, were less responsive to the treatment. Conversely, treatment MT significantly enhanced male androgen production from January onwards, together with an increase in proportions of running individuals (March), indicating that males were also responsive to this treatment at mid‐late phases of testicular development. Our data further support the strong influence of water temperature on the overall control of gonadal maturation in Senegalese sole. 相似文献
86.
Kenjiro FUKUSHIMA Nozomi EGUCHI Koichi OHNO Hideyuki KANEMOTO Masashi TAKAHASHI Hirotaka IGARASHI Aki OHMI Ko NAKASHIMA Hajime TSUJIMOTO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2016,78(2):265-269
Inflammatory colorectal polyp (ICRP), common in miniature dachshunds, presents with hematochezia, tenesmus
and mucoid feces. Although an 80% response rate has been reported when treated with prednisolone and
cyclosporine, effective treatment is needed for the remaining 20% of ICRP dogs. Leflunomide is an
immunosuppressive drug reported as effective in several immune-mediated diseases. In the present study, we
retrospectively evaluated the efficacy and adverse effects of leflunomide in 15 ICRP dogs that were refractory
to treatment with prednisolone and cyclosporine. Treatment efficacy was assessed by endoscopy, clinical
symptoms and rectal palpation. Adverse effects were determined by clinical symptoms and blood testing during
follow-up. The leflunomide treatment response rate was 93.3%. The median dosage of leflunomide and the median
response time were 3 mg/kg (range: 1.7–4.0 mg/kg) and 35 days (range: 20–119 days), respectively. Adverse
effects observed included lethargy (3 dogs), anorexia (1 dog), respiratory symptoms (1 dog), leukocytopenia (2
dogs), thrombocytopenia (1 dog), anemia (1 dog) and liver enzyme elevation (8 dogs). Most of the adverse
effects improved with symptomatic treatment and leflunomide discontinuation or dosage reduction. In
conclusion, leflunomide treatment is effective in ICRP dogs refractory to treatment with prednisolone and
cyclosporine. Because several adverse effects were observed, close monitoring is needed during leflunomide
treatment follow-up. 相似文献
87.
Nguyen V. Son Kazuyuki Uchida Atigan Thongtharb James K. Chambers Takuya E. Kishimoto Hirotaka Tomiyasu Aki Ohmi Hajime Tsujimoto Hiroyuki Nakayama 《Veterinary and comparative oncology》2019,17(3):345-353
A cell line named FB‐LCH01, derived from a dog diagnosed with Langerhans cell histiocytosis (LCH), was established and characterized. FB‐LCH01 had C‐shaped nucleoli, characterized by modal chromosome aberrations. The original tumour cells as well as established FB‐LCH01 cells were immunopositive for human leukocyte antigen‐DR, Iba‐1 and E‐cadherin, and immunonegative for CD163 and CD204, suggesting Langerhans cell origin. Furthermore, the characteristics of FB‐LCH01 were compared with those of two canine histiocytic sarcoma cell lines (PWC‐HS01 and FCR‐HS02) established previously. Expression of E‐cadherin was detected only in FB‐LCH01, but not in PWC‐HS01 and FCR‐HS02. All (n = 9) the severe combined immunodeficiency mice inoculated with the FB‐LCH01 cells developed subcutaneous tumour masses after 3 weeks. Eight of nine mice also developed metastatic lesions in the lymph nodes (8/8; 100%), lung (5/8; 62.5%), stomach (5/8; 62.5%), heart (4/8; 50%), pancreas (4/8; 50%), kidney (3/8; 37.5%), skin (3/8; 37.5%) and bone marrow (1/8; 12.5%). Tumour cells were pleomorphic and round‐ to polygonal‐shaped with prominent anisocytosis and anisokaryosis. The xenotransplanted tumour cells maintained the immunohistochemical features of the original tumour with persistent E‐cadherin expression at injection site and some visceral organs. In conclusion, the established cell line as well as the mice xenotransplant model in this study reflect the nature of canine LCH and may serve as promising models for investigating the patho‐tumorigenesis and therapy of the disease. 相似文献
88.
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90.
Nutritional values and antioxidative activities of whole peanuts and peanut skins for ruminant feeds 下载免费PDF全文
Chihiro Saito Sanae Asano Chizuko Kato Shintaro Kobayashi Ayaka Musha Hirotaka Kuribayashi Shouhei Moriguchi Yuuki Seto Tasuku Kawashima Masakazu Kobayashi Shigenobu Ishizaki Hiroshi Kajikawa 《Animal Science Journal》2016,87(1):54-60
This study was conducted to investigate the nutritive values of two peanut by‐products, nonstandardized whole peanuts and peanut skins, along with their effects on microbial growth and fermentation in the rumen, their roughage values, and their antioxidative activities by a digestion trial using four goats. The experimental rations were alfalfa haycube (basal ration), 85% alfalfa with 15% whole peanuts, and 70% alfalfa with 15% whole peanuts and 15% peanut skins. The ether extracts and crude protein in whole peanuts were 47% and 27% on a dry matter basis (DM) both with over 90% of digestibilities, resulting in total digestive nutrients (TDN) of 140%. Peanut skins also had a high energy value with 91% of TDN. Ruminal concentrations of total volatile fatty acids (VFA) and acetic acid decreased in the rations containing the peanut by‐products, but the NDF digestibility and ruminal microbial protein estimated from urinary purines was not altered by feeding the peanut by‐products. Plasma oxidative stress maker, malondialdehyde, tended to be lower when peanut skins were supplemented. Whole peanuts and peanut skins could be used as high‐energy and high‐protein diets for ruminants, and peanut skins would be expected as a feed having antioxidant functions. 相似文献