The Aerobee Sounding Rocket--A New Vehicle for Research in the Upper Atmosphere     

VAN Allen JA  Fraser LW  Floyd JF 《Science (New York, N.Y.)》1948,108(2818):746-747

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Atmospheric trends in methylchloroform and the global average for the hydroxyl radical     

Prinn R  Cunnold D  Rasmussen R  Simmonds P  Alyea F  Crawford A  Fraser P  Rosen R 《Science (New York, N.Y.)》1987,238(4829):945-950

Frequent atmospheric measurements of the anthropogenic compound methylchloroform that were made between 1978 and 1985 indicate that this species is continuing to increase significantly around the world. Reaction with the major atmospheric oxidant, the hydroxyl radical (OH), is the principal sink for this species. The observed mean trends for methylchloroform are 4.8, 5.4, 6.4, and 6.9 percent per year at Aldrigole (Ireland) and Cape Meares (Oregon), Ragged Point (Barbados), Point Matatula (American Samoa), and Cape Grim (Tasmania), respectively, from July 1978 to June 1985. These measured trends, combined with knowledge of industrial emissions, were used in an optimal estimation inversion scheme to deduce a globally averaged methylchloroform atmospheric lifetime of 6.3 (+ 1.2, -0.9) years (1sigma uncertainty) and a globally averaged tropospheric hydroxyl radical concentration of (7.7 +/- 1.4) x 10(5) radicals per cubic centimeter (1sigma uncertainty). These 7 years of gas chromatographic measurements, which comprise about 60,000 individual calibrated real-time air analyses, provide the most accurate estimates yet of the trends and lifetime of methylchloroform and of the global average for tropospheric hydroxyl radical levels. Accurate determination of hydroxyl radical levels is crucial to understanding global atmospheric chemical cycles and trends in the levels of trace gases such as methane.  相似文献   

Boycoff chicago!     

Eigner J  Watson JD  Haselkorn R  Signer E  Fraser D  Echols H 《Science (New York, N.Y.)》1968,162(3853):511

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An uncertain call to arms     

Fraser CM 《Science (New York, N.Y.)》2004,304(5669):359

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Adélie penguins and environmental change     

Ainley DG  Ballard G  Emslie SD  Fraser WR  Wilson PR  Woehler EJ 《Science (New York, N.Y.)》2003,300(5618):429-30; author reply 429-30

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Biochemistry. A natural choice for activating hydrogen     

Armstrong FA  Fontecilla-Camps JC 《Science (New York, N.Y.)》2008,321(5888):498-499

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Phylogenomics: intersection of evolution and genomics     

Eisen JA  Fraser CM 《Science (New York, N.Y.)》2003,300(5626):1706-1707

Much has been gained from genomic and evolutionary studies of species. Combining the perspectives of these different approaches suggests that an integrated phylogenomic approach will be beneficial.  相似文献   

The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin   总被引：1，自引：0，他引：1  

Nagano T  Mitchell JA  Sanz LA  Pauler FM  Ferguson-Smith AC  Feil R  Fraser P 《Science (New York, N.Y.)》2008,322(5908):1717-1720

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Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes     

Seshadri R  Adrian L  Fouts DE  Eisen JA  Phillippy AM  Methe BA  Ward NL  Nelson WC  Deboy RT  Khouri HM  Kolonay JF  Dodson RJ  Daugherty SC  Brinkac LM  Sullivan SA  Madupu R  Nelson KE  Kang KH  Impraim M  Tran K  Robinson JM  Forberger HA  Fraser CM  Zinder SH  Heidelberg JF 《Science (New York, N.Y.)》2005,307(5706):105-108

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Arrhythmias and transient changes in cardiac function after topical administration of one drop of phenylephrine 10% in an adult cat undergoing conjunctival graft     

Franci P  Leece EA  McConnell JF 《Veterinary anaesthesia and analgesia》2011,38(3):208-212

HistoryA 2-year-old, entire female, Somali cat weighing 3.8 kg was admitted for a conjunctival graft on the right eye, for treatment of an acute descemetocele. Medetomidine 4.2 μg kg^?1 and methadone 0.2 mg kg^?1 were administered by intramuscular injection as preanaesthetic medication. Anaesthesia was induced using diazepam 0.26 mg kg^?1 and propofol 4 mg kg^?1 administered by intravenous (IV) injection. Following endotracheal intubation, anaesthesia was maintained with isoflurane delivered in oxygen (1 L minute^?1) and nitrous oxide (2 L minute^?1) via a non-rebreathing system. Twenty minutes after induction of anaesthesia, one drop of a 10% phenylephrine hydrochloride solution was administered topically to the right eye.Physical examinationAfter phenylephrine administration, a decrease in heart rate (from 95 to 80 beats minute^?1) and an increase in arterial blood pressure occurred. The pulse then became difficult to palpate manually and multifocal ventricular premature contractions were observed on the electrocardiogram.ManagementNitrous oxide was discontinued and the isoflurane vaporizer setting was decreased from 1.5% to 0.5%. Lidocaine 1 mg kg^?1 IV was administered, this resulted in ventricular bigeminy. The quality of the femoral pulse improved and was regular in rhythm and character. Surgery was completed as fast as possible. The bigeminy progressively disappeared and before disconnecting the cat from the breathing system, there was a normal sinus rhythm with a heart rate of 85 beats minute^?1.Follow-upEchocardiography was performed during recovery and showed mitral and aortic valve insufficiency and dilation of the left ventricle, suggesting a reduction in systolic function. Echocardiography was repeated the following day and was normal.ConclusionsIn order to diminish the potential for cardiovascular sequelae associated with systemic absorption of ocular phenylephrine, less concentrated solutions, smaller drop size or different instillation techniques should be considered for topical use in small patients.  相似文献