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91.
OBJECTIVE: Adequate fruit and vegetable intake has been suggested to protect against colorectal cancer. However, several recent prospective studies have reported no association. We therefore examined the association between fruit and vegetable intakes and the risk of colorectal cancer in a prospective cohort study in Japan. DESIGN: Between June and August 1990, 47 605 Japanese men and women completed a self-administered questionnaire, including a food-frequency questionnaire. We divided the subjects into quartiles based on their self-reported fruit and vegetable consumption. There were 165 colon cancer and 110 rectal cancer incidences identified during 7 years of follow-up, to the end of December 1997. We used Cox proportional hazards models to estimate the relative risk (RR) of developing colorectal cancer according to the level of fruit and vegetable consumption, applying adjustments for potential confounders. RESULTS: No statistically significant association was observed between fruit and vegetable consumption and the risk of colorectal cancer. The multivariate RR of colon cancer in the highest quartile of fruit and vegetable intake compared with the lowest was 1.13 (95% confidence interval (CI) 0.73-1.75), the RR for vegetables alone was 1.24 (95% CI 0.79-1.95) and that for fruit alone was 1.45 (95% CI 0.85-2.47). The corresponding multivariate RRs for rectal cancer were 1.12 (95% CI 0.67-1.89), 1.14 (95% CI 0.67-1.93) and 1.41 (95% CI 0.73-2.73). CONCLUSIONS: We found no association between the consumption of fruit and vegetables and the risk of colorectal cancer among the Japanese population.  相似文献   
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ABSTRACT:   A microscopic bubble generating system (MBGS) has been developed to control dissolved oxygen (DO) levels suitable for fish farming. The MBGS has been tested to confirm its capability in net pens. Water conditions in a fish farm were monitored every two hours from June to October 2004 by setting an online vertical profiling system (OVPS) close to the net pen. DO in the net pen water decreased to physiologically stressful levels for the fish during the night (4.84–5.51 mg/L), while the DO was kept in saturated conditions during the day, due to oxygen supply from phytoplankton. The MBGS was operated from the evening to the morning of the next day for 16 h, to successfully create DO-saturated conditions in the net pen water at night. By using microscopic bubbles during the warm seasons, DO levels in the net pen water could be improved to a level suitable for fish farming. However, the low DO levels (<5.0 mg/L) of the bottom water occasionally extended to the net pen layers, despite the supply of microscopic bubbles to the water. To maintain the DO of the net pen water at levels suitable for fish farming, DO supply to the net pen water and the bottom water needs to be increased, and the organically enriched sediment just below the net pens needs to be treated.  相似文献   
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ABSTRACT:   We investigated changes in the reproductive patterns of mantis shrimp Oratosquilla oratoria concurrent with stock-abundance decline in Tokyo Bay, Japan. Stock abundance was high in the mid to late 1980s but decreased abruptly in the early 1990s. The yearly change in annual mean larval abundance was similar to that of stock abundance. Mantis shrimp in the bay have two spawning seasons, an early season (May–June) for ≥1-year-old individuals and a late season (July–September) for 0–1-year-old individuals. This general reproductive pattern does not differ among different stock-abundance levels. However, the monthly pattern in larval abundance has changed with stock-abundance decline; larval abundance from the early spawning season was highest in the high-stock-abundance period, and it decreased significantly in the low-stock-abundance period, probably as a result of decreased spawning-stock abundance of large female mantis shrimp ≥1-year-old. Correlation analysis on the egg production index and larval abundance suggested that during this low-stock-abundance period the population is supported mostly by late-hatched larvae spawned by small, 0–1-year-old female mantis shrimp. Considering the reproductive pattern and the present status of the fishery, the stock of small female mantis shrimp should be conserved to enhance reproduction of the population for stock recovery.  相似文献   
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Abstract. A new virus, provisionally named Herpesvirus vitreum, was isolated from hyperplastic epidermal tissue from a walleye, Stizostedion vitreum vitreum (Mitchill), taken in Saskatchewan, Canada. The virus, which was isolated in the walleye ovarian (WO) cell line, was identified as a herpesvirus on the basis of size (190–230 nm), morphology and apparent pattern of replication. The virus, which passes polycarbonate membranes of 200 nm mean pore diameter, was ether-labile. Virus replicated in WC-1 cells at 4 and 15°C, but not at 20°C. Although walleye cell lines (WO, WC-1, We-2) were susceptible to infection at 15°C, non-period cell lines were refractory. Syncytial formation and lysis occurred in susceptible cell lines. Virus was quantified by plaque assay at 13 to 15°C for two weeks. Replication was inhibited by 10-3.0m phosphonoacetate and by 10-5.0m 5-bromodeoxyuridine (BUDR), but addition of excess thymidine reversed the inhibition by BUDR. Viral replication in WO cells, but not in WC-1 cells, was inhibited by the antiherpetic drug acyclovir (10-5.0m ). The relationship of the herpesvirus isolate and epithelial neoplasms was not determined.  相似文献   
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ABSTRACT: Temperature and salinity ranges in which Gymnodinium catenatum (Hiroshima Bay strain) showed specific growth rates higher than 0.2/day were approximately 20–30°C and 20–32. The specific growth rate (μ), expressed as a polynomial equation as functions of temperature ( T ; °C) and salinity ( S ) were μ = (−6.84 × 10−4 T 2 + 0.0354 T – 0.213) × (−1.03 × 10−3 S 2 + 0.0579 S – 0.548)/0.31; the maximum growth rate (0.31/day) was obtained at 25°C and 30. From a comparison with field data recording temperature, salinity and light intensity, this species may be expected to bloom from summer to autumn in Hiroshima Bay.  相似文献   
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