Acromegaly in 14 Cats   总被引：3，自引：0，他引：3  

Mark E. Peterson DVM    R. Steven Taylor DVM    Deborah S. Greco DVM    Richard W. Nelson DVM    John F. Randolph DVM    Melissa S. Foodman DVM    Scott D. Moroff DVM    Susan A. Morrison DVM  Clinton D. Lothrop DVM PhD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1990,4(4):192-201

Acromegaly was diagnosed in 14 middle-aged to old cats of mixed breeding. Thirteen (93%) of the cats were male and one was female. The earliest clinical signs in the 14 cats included polyuria, polydipsia, polyphagia, all of which were associated with untreated diabetes mellitus. All developed severe insulin resistance within a few months; peak insulin dosages required to control severe hyperglycemia ranged from 20 to 130 U per day. Other clinical findings weeks to months after diagnosis included enlargement of one or more organs (e.g., liver, heart, kidneys, and tongue) (n = 14), cardiomyopathy (n = 13), increase in body size and weight gain (n = 8), nephropathy associated with azotemia and clinical signs of renal failure (n = 7), degenerative arthropathy (n = 6), and central nervous system signs (i.e., circling and seizures) caused by enlargement of the pituitary tumor (n = 2). The diagnosis of acromegaly was confirmed by demonstration of extremely high basal serum growth hormone concentrations (22 to 131 micrograms/l) in all cats. Computerized tomography disclosed a mass in the region of the pituitary gland and hypothalamus in five of the six cats in which it was performed. Two cats were treated by cobalt radiotherapy followed by administration of a somatostatin analogue (octreotide), whereas two cats were treated with octreotide alone. Treatment had little to no effect in decreasing serum GH concentrations in any of the cats. Eleven of the 14 cats were euthanized or died four to 42 months (median survival time, 20.5 months) after the onset of acromegaly because of renal failure (n = 2), congestive heart failure (n = 1), concomitant renal failure and congestive heart failure (n = 3), progressive neurologic signs (n = 2), persistent anorexia and lethargy of unknown cause (n = 1), the owner's unwillingness to treat the diabetes mellitus (n = 1), or unknown causes (n = 1). Results of necropsy examination in ten cats revealed a large pituitary acidophil adenoma (n = 10), marked left ventricular and septal hypertrophy (n = 7), dilated cardiomyopathy (n = 1), arthropathy affecting the shoulder, elbow, or stifle (n = 5), and glomerulopathy characterized by expansion of the mesangial matrix and variable periglomerular fibrosis (n = 10).  相似文献   

Urolithiasis. Terms and concepts     

C A Osborne  C W Clinton 《Veterinary Clinics of North America: Small Animal Practice》1986,16(1):3-17

Urolithiasis is a general term that encompasses formulation of urinary tract stones as a sequela of one or more underlying abnormalities. A variety of terms have been used to describe the characteristics of uroliths based on mineral composition, location, and/or shape. Knowledge of the origins and meanings of these terms will facilitate understanding of the cause, detection, treatment, and prevention of uroliths.  相似文献   

Variation in Stream Water Quality in an Urban Headwater Stream in the Southern Appalachians     

Barton D. Clinton  James M. Vose 《Water, air, and soil pollution》2006,169(1-4):331-353

We examined the influence of a forested landscape on the quality of water in a stream originating on an urban landscape and flowing through National Forest lands. Sample sites included an urban stream (URB), a site on the same stream but within a National Forest (FOR) and 2 km downstream from the URB site, and a small, undisturbed, forested reference tributary of the main stream (REF). We monitored stream water quality from March 2002 through June 2003. Average base flows for the three stream sites were URB = 184 L s^?1, FOR = 420 L s^?1, and REF = 17 L s^?1. We analyzed weekly stream water samples for NO₃ ^?, NH₄ ⁺, PO₄ ⁺, Cl^?, K, Ca, Mg, SO₄, SiO₂, pH, conductivity, total suspended solids (TSS), and bacteria on a monthly basis. Most solutes were higher in concentration at the URB site, as were conductivity, TSS, and bacteria counts. Reductions in NO₃ ^?, NH₄ ⁺, and PO₄ ⁺ concentrations between the URB and FOR sites were inferred from changes in nutrient:chloride ratios. Bacteria populations were greater and more responsive to stream temperature at the URB site. Water quality responses to changes in stream discharge varied among sites but were greater at the URB site. By all measures, water quality was consistently higher at the FOR site than at the URB site.  相似文献   

Effects of mixing radiata pine needles and understory litters on decomposition and nutrients release   总被引：1，自引：0，他引：1  

Girisha K. Ganjegunte  Leo M. Condron  Peter W. Clinton  Murray R. Davis 《Biology and Fertility of Soils》2005,41(5):310-319

A microcosm experiment was conducted to understand the impacts of mixing radiata pine (Pinus radiata D. Don) needle litter and understory (gorse—Ulex europaeus L., broom—Cytisus scoparius L., bracken—Pteridium aquilinum L., and lotus—Lotus pedunculatus L.) litter materials on decomposition and nutrient release dynamics. Mixing of pine needle litter with understory litter material had significant impacts on both the rate of decomposition and nutrient release patterns of pine litter as well as that of the understory species. Incubation in microcosms over 10 months resulted in significantly lower mass loss of radiata pine needle litter mixed with broom and lotus litters (35.8±8.4 and 41.3±0.8%, respectively) than pure pine needle litter (63.5±2.3%). Mixing with pine needle litter significantly increased the mass loss of broom (53.1±6.1%) compared to that of pure broom (30.2±1.0%). Significant transfers of nutrients, especially of magnesium and potassium, were observed in litter mixture treatments. Concentration of K in litter materials was found to be the most limiting factor for the decomposing microorganisms in the present study. The findings of this study suggest that management of understory litter composition via weed control could be used to manipulate carbon turnover and nutrient release in the forest floor. Also, initial selection of understory species will be important and could be managed.  相似文献   

BOTANY IN RELATION TO AGRICULTURE     

Clinton GP 《Science (New York, N.Y.)》1916,43(1097):1-13

  相似文献   

A whiff of oxygen before the great oxidation event?   总被引：1，自引：0，他引：1  

Anbar AD  Duan Y  Lyons TW  Arnold GL  Kendall B  Creaser RA  Kaufman AJ  Gordon GW  Scott C  Garvin J  Buick R 《Science (New York, N.Y.)》2007,317(5846):1903-1906

High-resolution chemostratigraphy reveals an episode of enrichment of the redox-sensitive transition metals molybdenum and rhenium in the late Archean Mount McRae Shale in Western Australia. Correlations with organic carbon indicate that these metals were derived from contemporaneous seawater. Rhenium/osmium geochronology demonstrates that the enrichment is a primary sedimentary feature dating to 2501 +/- 8 million years ago (Ma). Molybdenum and rhenium were probably supplied to Archean oceans by oxidative weathering of crustal sulfide minerals. These findings point to the presence of small amounts of O2 in the environment more than 50 million years before the start of the Great Oxidation Event.  相似文献   

Genetic dissection of transcriptional regulation in budding yeast     

Brem RB  Yvert G  Clinton R  Kruglyak L 《Science (New York, N.Y.)》2002,296(5568):752-755

To begin to understand the genetic architecture of natural variation in gene expression, we carried out genetic linkage analysis of genomewide expression patterns in a cross between a laboratory strain and a wild strain of Saccharomyces cerevisiae. Over 1500 genes were differentially expressed between the parent strains. Expression levels of 570 genes were linked to one or more different loci, with most expression levels showing complex inheritance patterns. The loci detected by linkage fell largely into two categories: cis-acting modulators of single genes and trans-acting modulators of many genes. We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function.  相似文献   

Impact of early-season water deficits on Russet Burbank plant development,tuber yield and quality   总被引：2，自引：0，他引：2  

Clinton C. Shock  James C. Zalewski  Timothy D. Stieber  Denise S. Burnett 《American Journal of Potato Research》1992,69(12):793-803

Russet Burbank potatoes grown on Owyhee silt loam were subjected to early-season moisture stress by delaying initiation of furrow irrigation up to seven weeks after planting. A range of water stress treatments from 4 to 7 weeks after planting resulted in reduced plant size, tuber number and total tuber weight per plant 8 1/2 weeks after planting. Early-season water stress resulting from delayed irrigation onset was associated with improved tuber quality at harvest. Plants water stressed before tuber initiation had fewer tubers with dark stem-end fry colors, reduced percentage of US No. 2 potatoes, and increased percentage and size of US No. 1 potatoes. Increasing duration of soil water potential below -60 kPa early in the season was associated with declining total yield in 1985 but not in 1986. To obtain optimum yield and processing quality, the first irrigation should be no sooner than full plant emergence.  相似文献